The neural correlates of obsessive-compulsive disorder: a multimodal perspective

Obsessive-compulsive disorder (OCD) is one of the most debilitating psychiatric conditions. An extensive body of the literature has described some of the neurobiological mechanisms underlying the core manifestations of the disorder. Nevertheless, most reports have focused on individual modalities of...

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Autores: Moreira, P. S., Marques, Paulo, Soriano Mas, Carles, Magalhães, R., Sousa, N., Soares, J. M., Morgado, Pedro
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2017
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/124275
Acesso em linha:https://hdl.handle.net/2445/124275
Access Level:Acceso aberto
Palavra-chave:Neurosi obsessiva
Neurobiologia
Obsessive-compulsive disorder
Neurobiology
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spelling The neural correlates of obsessive-compulsive disorder: a multimodal perspectiveMoreira, P. S.Marques, PauloSoriano Mas, CarlesMagalhães, R.Sousa, N.Soares, J. M.Morgado, PedroNeurosi obsessivaNeurobiologiaObsessive-compulsive disorderNeurobiologyObsessive-compulsive disorder (OCD) is one of the most debilitating psychiatric conditions. An extensive body of the literature has described some of the neurobiological mechanisms underlying the core manifestations of the disorder. Nevertheless, most reports have focused on individual modalities of structural/functional brain alterations, mainly through targeted approaches, thus possibly precluding the power of unbiased exploratory approaches. Eighty subjects (40 OCD and 40 healthy controls) participated in a multimodal magnetic resonance imaging (MRI) investigation, integrating structural and functional data. Voxel-based morphometry analysis was conducted to compare between-group volumetric differences. The whole-brain functional connectome, derived from resting-state functional connectivity (FC), was analyzed with the network-based statistic methodology. Results from structural and functional analysis were integrated in mediation models. OCD patients revealed volumetric reductions in the right superior temporal sulcus. Patients had significantly decreased FC in two distinct subnetworks: the first, involving the orbitofrontal cortex, temporal poles and the subgenual anterior cingulate cortex; the second, comprising the lingual and postcentral gyri. On the opposite, a network formed by connections between thalamic and occipital regions had significantly increased FC in patients. Integrative models revealed direct and indirect associations between volumetric alterations and FC networks. This study suggests that OCD patients display alterations in brain structure and FC, involving complex networks of brain regions. Furthermore, we provided evidence for direct and indirect associations between structural and functional alterations representing complex patterns of interactions between separate brain regions, which may be of upmost relevance for explaining the pathophysiology of the disorder.Nature Publishing2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/124275Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/tp.2017.189Translational Psychiatry, 2017, vol. 7https://doi.org/10.1038/tp.2017.189info:eu-repo/grantAgreement/EC/FP7/259772cc by-nc-nd (c) Moreira et al., 2017http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1242752026-05-27T06:46:51Z
dc.title.none.fl_str_mv The neural correlates of obsessive-compulsive disorder: a multimodal perspective
title The neural correlates of obsessive-compulsive disorder: a multimodal perspective
spellingShingle The neural correlates of obsessive-compulsive disorder: a multimodal perspective
Moreira, P. S.
Neurosi obsessiva
Neurobiologia
Obsessive-compulsive disorder
Neurobiology
title_short The neural correlates of obsessive-compulsive disorder: a multimodal perspective
title_full The neural correlates of obsessive-compulsive disorder: a multimodal perspective
title_fullStr The neural correlates of obsessive-compulsive disorder: a multimodal perspective
title_full_unstemmed The neural correlates of obsessive-compulsive disorder: a multimodal perspective
title_sort The neural correlates of obsessive-compulsive disorder: a multimodal perspective
dc.creator.none.fl_str_mv Moreira, P. S.
Marques, Paulo
Soriano Mas, Carles
Magalhães, R.
Sousa, N.
Soares, J. M.
Morgado, Pedro
author Moreira, P. S.
author_facet Moreira, P. S.
Marques, Paulo
Soriano Mas, Carles
Magalhães, R.
Sousa, N.
Soares, J. M.
Morgado, Pedro
author_role author
author2 Marques, Paulo
Soriano Mas, Carles
Magalhães, R.
Sousa, N.
Soares, J. M.
Morgado, Pedro
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Neurosi obsessiva
Neurobiologia
Obsessive-compulsive disorder
Neurobiology
topic Neurosi obsessiva
Neurobiologia
Obsessive-compulsive disorder
Neurobiology
description Obsessive-compulsive disorder (OCD) is one of the most debilitating psychiatric conditions. An extensive body of the literature has described some of the neurobiological mechanisms underlying the core manifestations of the disorder. Nevertheless, most reports have focused on individual modalities of structural/functional brain alterations, mainly through targeted approaches, thus possibly precluding the power of unbiased exploratory approaches. Eighty subjects (40 OCD and 40 healthy controls) participated in a multimodal magnetic resonance imaging (MRI) investigation, integrating structural and functional data. Voxel-based morphometry analysis was conducted to compare between-group volumetric differences. The whole-brain functional connectome, derived from resting-state functional connectivity (FC), was analyzed with the network-based statistic methodology. Results from structural and functional analysis were integrated in mediation models. OCD patients revealed volumetric reductions in the right superior temporal sulcus. Patients had significantly decreased FC in two distinct subnetworks: the first, involving the orbitofrontal cortex, temporal poles and the subgenual anterior cingulate cortex; the second, comprising the lingual and postcentral gyri. On the opposite, a network formed by connections between thalamic and occipital regions had significantly increased FC in patients. Integrative models revealed direct and indirect associations between volumetric alterations and FC networks. This study suggests that OCD patients display alterations in brain structure and FC, involving complex networks of brain regions. Furthermore, we provided evidence for direct and indirect associations between structural and functional alterations representing complex patterns of interactions between separate brain regions, which may be of upmost relevance for explaining the pathophysiology of the disorder.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/124275
url https://hdl.handle.net/2445/124275
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/tp.2017.189
Translational Psychiatry, 2017, vol. 7
https://doi.org/10.1038/tp.2017.189
info:eu-repo/grantAgreement/EC/FP7/259772
dc.rights.none.fl_str_mv cc by-nc-nd (c) Moreira et al., 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Moreira et al., 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing
publisher.none.fl_str_mv Nature Publishing
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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