Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes

8 pages, 6 figures, 3 tables, 3 schemes

Detalles Bibliográficos
Autores: Gutiérrez-González, Alejandro, Destito, Paolo, Couceiro, José R., Pérez-González, Cibran, López García, Fernando José, Mascareñas, José L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/349357
Acceso en línea:http://hdl.handle.net/10261/349357
https://api.elsevier.com/content/abstract/scopus_id/85107963044
Access Level:acceso abierto
Palabra clave:Biocompatible reactions
Bioorthogonal reactions
Click chemistry
Ruthenium
Thioalkynes
ruthenium
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spelling Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) ComplexesGutiérrez-González, AlejandroDestito, PaoloCouceiro, José R.Pérez-González, CibranLópez García, Fernando JoséMascareñas, José L.Biocompatible reactionsBioorthogonal reactionsClick chemistryRutheniumThioalkynesruthenium8 pages, 6 figures, 3 tables, 3 schemesTailored ruthenium sandwich complexes bearing photoresponsive arene ligands can efficiently promote azide-thioalkyne cycloaddition (RuAtAC) when irradiated with UV light. The reactions can be performed in a bioorthogonal manner in aqueous mixtures containing biological components. The strategy can also be applied for the selective modification of biopolymers, such as DNA or peptides. Importantly, this ruthenium-based technology and the standard copper-catalyzed azide-alkyne cycloaddition (CuAAC) proved to be compatible and mutually orthogonal.This research received financial support from the Spanish MINECO (SAF2016-76689-R, CTQ2017-84767-P and PID2019-106184GB-I00, and a FPU predoctoral Fellowship to AGG), the Xunta de Galicia (ED431C 2017/19, 2015-CP082, Centro Singular de Investigación de Galicia accreditation 2019–2022, ED431G 2019/03), the ERDF, and the ERC (Adv. Grant No. 340055). The Orfeo-Cinqa network (CTQ2016-81797-REDC) is also acknowledged.Peer reviewedWiley-VCHMinisterio de Economía y Competitividad (España)Xunta de GaliciaEuropean CommissionLópez García, Fernando José [0000-0002-0235-6858]Mascareñas, José L [0000-0002-7789-700X]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/349357https://api.elsevier.com/content/abstract/scopus_id/85107963044reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//SAF2016-76689-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-84767-Pinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106184GB-I00Angewandte Chemie (International ed. in English)https://doi.org/10.1002/anie.202103645Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3493572026-05-22T06:33:51Z
dc.title.none.fl_str_mv Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
title Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
spellingShingle Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
Gutiérrez-González, Alejandro
Biocompatible reactions
Bioorthogonal reactions
Click chemistry
Ruthenium
Thioalkynes
ruthenium
title_short Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
title_full Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
title_fullStr Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
title_full_unstemmed Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
title_sort Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
dc.creator.none.fl_str_mv Gutiérrez-González, Alejandro
Destito, Paolo
Couceiro, José R.
Pérez-González, Cibran
López García, Fernando José
Mascareñas, José L.
author Gutiérrez-González, Alejandro
author_facet Gutiérrez-González, Alejandro
Destito, Paolo
Couceiro, José R.
Pérez-González, Cibran
López García, Fernando José
Mascareñas, José L.
author_role author
author2 Destito, Paolo
Couceiro, José R.
Pérez-González, Cibran
López García, Fernando José
Mascareñas, José L.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Xunta de Galicia
European Commission
López García, Fernando José [0000-0002-0235-6858]
Mascareñas, José L [0000-0002-7789-700X]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Biocompatible reactions
Bioorthogonal reactions
Click chemistry
Ruthenium
Thioalkynes
ruthenium
topic Biocompatible reactions
Bioorthogonal reactions
Click chemistry
Ruthenium
Thioalkynes
ruthenium
description 8 pages, 6 figures, 3 tables, 3 schemes
publishDate 2021
dc.date.none.fl_str_mv 2021
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/349357
https://api.elsevier.com/content/abstract/scopus_id/85107963044
url http://hdl.handle.net/10261/349357
https://api.elsevier.com/content/abstract/scopus_id/85107963044
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI//SAF2016-76689-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-84767-P
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106184GB-I00
Angewandte Chemie (International ed. in English)
https://doi.org/10.1002/anie.202103645
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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