Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations

Purpose: Articular cartilage has limited repair capacity. Two different implant devices for articular cartilage regeneration were tested in vivo in a sheep model to evaluate the effect of subchondral bone anchoring for tissue repair. Methods: The implants were placed with press-fit technique in a ca...

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Autores: Vikingsson, Line Karina Alva, Sancho-Tello Valls, Maria, Ruiz Sauri, Amparo, Martínez Díaz, Santos, Carda, Carmen, Monllau Garcia, Joan Carles, Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829, Gallego-Ferrer, Gloria|||0000-0002-2428-0903, Gómez Ribelles, José Luís|||0000-0001-9099-0885
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/74862
Acceso en línea:https://riunet.upv.es/handle/10251/74862
Access Level:acceso abierto
Palabra clave:Biomaterials
Cartilage engineering
Tissue engineering
Polycaprolactone
Subchondral bone alterations
MAQUINAS Y MOTORES TERMICOS
FISICA APLICADA
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spelling Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterationsVikingsson, Line Karina AlvaSancho-Tello Valls, MariaRuiz Sauri, AmparoMartínez Díaz, SantosCarda, CarmenMonllau Garcia, Joan CarlesGómez-Tejedor, José-Antonio|||0000-0001-6854-0829Gallego-Ferrer, Gloria|||0000-0002-2428-0903Gómez Ribelles, José Luís|||0000-0001-9099-0885BiomaterialsCartilage engineeringTissue engineeringPolycaprolactoneSubchondral bone alterationsMAQUINAS Y MOTORES TERMICOSFISICA APLICADAPurpose: Articular cartilage has limited repair capacity. Two different implant devices for articular cartilage regeneration were tested in vivo in a sheep model to evaluate the effect of subchondral bone anchoring for tissue repair. Methods: The implants were placed with press-fit technique in a cartilage defect after microfracture surgery in the femoral condyle of the knee joint of the sheep and histologic and mechanical evaluation was done 4.5 months later. The first group consisted of a biodegradable polycaprolactone (PCL) scaffold with double porosity. The second test group consisted of a PCL scaffold attached to a poly(L-lactic acid) (PLLA) pin anchored to the subchondral bone. Results: For both groups most of the defects (75%) showed an articular surface that was completely or almost completely repaired with a neotissue. Nevertheless, the surface had a rougher appearance than controls and the repair tissue was immature. In the trials with solely scaffold implantation, severe subchondral bone alterations were seen with many large nodular formations. These alterations were ameliorated when implanting the scaffold with a subchondral bone anchoring pin. Discussions: The results show that tissue repair is improved by implanting a PCL scaffold compared to solely microfracture surgery, and most importantly, that subchondral bone alterations, normally seen after microfracture surgery, were partially prevented when implanting the PCL scaffold with a fixation system to the subchondral bone.This work was funded by the Spanish Ministry of Economy and Competitiveness (MINECO) through the MAT2013-46467-C4-R project (including FEDER financial support). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund.WichtigDepartamento de Física AplicadaEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialDepartamento de Termodinámica AplicadaEscuela Técnica Superior de Ingeniería Geodésica, Cartográfica y TopográficaCentro de Biomateriales e Ingeniería TisularEscuela Técnica Superior de Ingeniería IndustrialMinisterio de Economía y CompetitividadCentro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y NanomedicinaRepositorio Institucional de la Universitat Politècnica de València Riunet20152015-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/74862reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2013-46467-C4-4-R ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVAMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2013-46467-C4-1-R ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVAopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/748622026-06-13T07:49:27Z
dc.title.none.fl_str_mv Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations
title Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations
spellingShingle Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations
Vikingsson, Line Karina Alva
Biomaterials
Cartilage engineering
Tissue engineering
Polycaprolactone
Subchondral bone alterations
MAQUINAS Y MOTORES TERMICOS
FISICA APLICADA
title_short Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations
title_full Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations
title_fullStr Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations
title_full_unstemmed Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations
title_sort Implantation of a polycaprolactone scaffold with subchondral bone anchoring ameliorates nodules formation and other tissue alterations
dc.creator.none.fl_str_mv Vikingsson, Line Karina Alva
Sancho-Tello Valls, Maria
Ruiz Sauri, Amparo
Martínez Díaz, Santos
Carda, Carmen
Monllau Garcia, Joan Carles
Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829
Gallego-Ferrer, Gloria|||0000-0002-2428-0903
Gómez Ribelles, José Luís|||0000-0001-9099-0885
author Vikingsson, Line Karina Alva
author_facet Vikingsson, Line Karina Alva
Sancho-Tello Valls, Maria
Ruiz Sauri, Amparo
Martínez Díaz, Santos
Carda, Carmen
Monllau Garcia, Joan Carles
Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829
Gallego-Ferrer, Gloria|||0000-0002-2428-0903
Gómez Ribelles, José Luís|||0000-0001-9099-0885
author_role author
author2 Sancho-Tello Valls, Maria
Ruiz Sauri, Amparo
Martínez Díaz, Santos
Carda, Carmen
Monllau Garcia, Joan Carles
Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829
Gallego-Ferrer, Gloria|||0000-0002-2428-0903
Gómez Ribelles, José Luís|||0000-0001-9099-0885
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Física Aplicada
Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Departamento de Termodinámica Aplicada
Escuela Técnica Superior de Ingeniería Geodésica, Cartográfica y Topográfica
Centro de Biomateriales e Ingeniería Tisular
Escuela Técnica Superior de Ingeniería Industrial
Ministerio de Economía y Competitividad
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Biomaterials
Cartilage engineering
Tissue engineering
Polycaprolactone
Subchondral bone alterations
MAQUINAS Y MOTORES TERMICOS
FISICA APLICADA
topic Biomaterials
Cartilage engineering
Tissue engineering
Polycaprolactone
Subchondral bone alterations
MAQUINAS Y MOTORES TERMICOS
FISICA APLICADA
description Purpose: Articular cartilage has limited repair capacity. Two different implant devices for articular cartilage regeneration were tested in vivo in a sheep model to evaluate the effect of subchondral bone anchoring for tissue repair. Methods: The implants were placed with press-fit technique in a cartilage defect after microfracture surgery in the femoral condyle of the knee joint of the sheep and histologic and mechanical evaluation was done 4.5 months later. The first group consisted of a biodegradable polycaprolactone (PCL) scaffold with double porosity. The second test group consisted of a PCL scaffold attached to a poly(L-lactic acid) (PLLA) pin anchored to the subchondral bone. Results: For both groups most of the defects (75%) showed an articular surface that was completely or almost completely repaired with a neotissue. Nevertheless, the surface had a rougher appearance than controls and the repair tissue was immature. In the trials with solely scaffold implantation, severe subchondral bone alterations were seen with many large nodular formations. These alterations were ameliorated when implanting the scaffold with a subchondral bone anchoring pin. Discussions: The results show that tissue repair is improved by implanting a PCL scaffold compared to solely microfracture surgery, and most importantly, that subchondral bone alterations, normally seen after microfracture surgery, were partially prevented when implanting the PCL scaffold with a fixation system to the subchondral bone.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/74862
url https://riunet.upv.es/handle/10251/74862
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2013-46467-C4-4-R ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2013-46467-C4-1-R ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wichtig
publisher.none.fl_str_mv Wichtig
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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