Molecular basis of the sticholysin-membrane interaction on the structure of the pore and the effects of lipids

The usefulness of toxicity across the tree of life is far beyond doubt. Most, if not all, organisms produce compounds that can be used for attack and/or defense against external entities. Some of the most specialized of these compounds are toxic proteins, among which pore-forming toxins (PFTs) parti...

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Detalhes bibliográficos
Autor: Palacios Ortega, Juan
Formato: tesis doctoral
Fecha de publicación:2021
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/5594
Acesso em linha:https://hdl.handle.net/20.500.14352/5594
Access Level:acceso abierto
Palavra-chave:612.017.4(043.2)
Toxins
Toxinas
antitoxinas
Bioquímica (Química)
Fisiología
2411 Fisiología Humana
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spelling Molecular basis of the sticholysin-membrane interaction on the structure of the pore and the effects of lipidsBases moleculares de la interacción esticolisina-membrana sobre la estructura del poro y los efectos de los lípidos.Palacios Ortega, Juan612.017.4(043.2)ToxinsToxinasantitoxinasBioquímica (Química)Fisiología2411 Fisiología HumanaThe usefulness of toxicity across the tree of life is far beyond doubt. Most, if not all, organisms produce compounds that can be used for attack and/or defense against external entities. Some of the most specialized of these compounds are toxic proteins, among which pore-forming toxins (PFTs) particularly excel. PFTs are present in all kingdoms of life. Given the wide variety of PFTs, one can expect a multitude of different specificities and mechanisms of action, of which we will certainly take advantage at some point. For that, a thorough characterization of PFTs and their functionality is necessary. In this thesis, we have taken further the characterization of sticholysins, small PFTs produced by the sea anemone Stichodactyla helianthus...Universidad Complutense de MadridMartínez del Pozo, ÁlvaroPeter Slotte, JohanUniversidad Complutense de Madrid20212021-07-3020212021-07-30doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/5594reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/55942026-06-02T12:44:21Z
dc.title.none.fl_str_mv Molecular basis of the sticholysin-membrane interaction on the structure of the pore and the effects of lipids
Bases moleculares de la interacción esticolisina-membrana sobre la estructura del poro y los efectos de los lípidos.
title Molecular basis of the sticholysin-membrane interaction on the structure of the pore and the effects of lipids
spellingShingle Molecular basis of the sticholysin-membrane interaction on the structure of the pore and the effects of lipids
Palacios Ortega, Juan
612.017.4(043.2)
Toxins
Toxinas
antitoxinas
Bioquímica (Química)
Fisiología
2411 Fisiología Humana
title_short Molecular basis of the sticholysin-membrane interaction on the structure of the pore and the effects of lipids
title_full Molecular basis of the sticholysin-membrane interaction on the structure of the pore and the effects of lipids
title_fullStr Molecular basis of the sticholysin-membrane interaction on the structure of the pore and the effects of lipids
title_full_unstemmed Molecular basis of the sticholysin-membrane interaction on the structure of the pore and the effects of lipids
title_sort Molecular basis of the sticholysin-membrane interaction on the structure of the pore and the effects of lipids
dc.creator.none.fl_str_mv Palacios Ortega, Juan
author Palacios Ortega, Juan
author_facet Palacios Ortega, Juan
author_role author
dc.contributor.none.fl_str_mv Martínez del Pozo, Álvaro
Peter Slotte, Johan
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612.017.4(043.2)
Toxins
Toxinas
antitoxinas
Bioquímica (Química)
Fisiología
2411 Fisiología Humana
topic 612.017.4(043.2)
Toxins
Toxinas
antitoxinas
Bioquímica (Química)
Fisiología
2411 Fisiología Humana
description The usefulness of toxicity across the tree of life is far beyond doubt. Most, if not all, organisms produce compounds that can be used for attack and/or defense against external entities. Some of the most specialized of these compounds are toxic proteins, among which pore-forming toxins (PFTs) particularly excel. PFTs are present in all kingdoms of life. Given the wide variety of PFTs, one can expect a multitude of different specificities and mechanisms of action, of which we will certainly take advantage at some point. For that, a thorough characterization of PFTs and their functionality is necessary. In this thesis, we have taken further the characterization of sticholysins, small PFTs produced by the sea anemone Stichodactyla helianthus...
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-07-30
2021
2021-07-30
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/5594
url https://hdl.handle.net/20.500.14352/5594
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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