The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction

Cardiac lipotoxicity is involved in the cardiac functional consequences associated with obesity. Therefore, the aim of this study was to explore whether changes in the mitochondrial lipid cardiac profle could refect diferences in cardiac function and structure in obese and non-obese rats with myocar...

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Autores: Marín-Royo, Gema, Ortega-Hernández, Adriana, Martínez Martínez, Ernesto, Jurado-López, Raquel, Luaces, María, Islas, Fabian, Gómez-Garre, Dulcenombre, Lagunas, Esther, Ramchandani, Bunty, García-Bouza, Mónica, Nieto, María Luisa, Cachofeiro Ramos, María Victoria
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/115420
Acceso en línea:https://hdl.handle.net/20.500.14352/115420
Access Level:acceso abierto
Palabra clave:616-056.25
cardiac lipotoxicity
miRNAs
myocardial infarction
obesity
Ciencias Biomédicas
32 Ciencias Médicas
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spelling The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial InfarctionMarín-Royo, GemaOrtega-Hernández, AdrianaMartínez Martínez, ErnestoJurado-López, RaquelLuaces, MaríaIslas, FabianGómez-Garre, DulcenombreLagunas, EstherRamchandani, BuntyGarcía-Bouza, MónicaNieto, María LuisaCachofeiro Ramos, María Victoria616-056.25cardiac lipotoxicitymiRNAsmyocardial infarctionobesityCiencias Biomédicas32 Ciencias MédicasCardiac lipotoxicity is involved in the cardiac functional consequences associated with obesity. Therefore, the aim of this study was to explore whether changes in the mitochondrial lipid cardiac profle could refect diferences in cardiac function and structure in obese and non-obese rats with myocardial infarction (MI). Whether these changes can also be refected in a specifc plasma miRNA signature as markers of cardiac damage was also evaluated. Rats were fed with either standard (3.5% fat) or high fat diet (35% fat) for 6 weeks before the induction of MI and sacrifced 4 weeks later. MI showed cardiac lipotoxicity independently of the presence of obesity, although obese and non-obese rats did not present the same cardiac lipid profle at mitochondrial level. Several cardiac lipid species in mitochondria, including cardiolipins and triglycerides, were associated with myocardial fbrosis, with mitochondrial triglyceride levels being independently associated with it; this supports that lipotoxicity can afect cardiac function. MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese and non-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardial fbrosis, with miRNA 15b-5p levels being independently associated with cardiac fbrosis. This could support that lipotoxicity could afect heart function by modulating plasma miRNAs.Nature PortfolioUniversidad Complutense de Madrid20192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/115420reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1154202026-06-02T12:44:21Z
dc.title.none.fl_str_mv The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction
title The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction
spellingShingle The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction
Marín-Royo, Gema
616-056.25
cardiac lipotoxicity
miRNAs
myocardial infarction
obesity
Ciencias Biomédicas
32 Ciencias Médicas
title_short The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction
title_full The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction
title_fullStr The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction
title_full_unstemmed The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction
title_sort The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction
dc.creator.none.fl_str_mv Marín-Royo, Gema
Ortega-Hernández, Adriana
Martínez Martínez, Ernesto
Jurado-López, Raquel
Luaces, María
Islas, Fabian
Gómez-Garre, Dulcenombre
Lagunas, Esther
Ramchandani, Bunty
García-Bouza, Mónica
Nieto, María Luisa
Cachofeiro Ramos, María Victoria
author Marín-Royo, Gema
author_facet Marín-Royo, Gema
Ortega-Hernández, Adriana
Martínez Martínez, Ernesto
Jurado-López, Raquel
Luaces, María
Islas, Fabian
Gómez-Garre, Dulcenombre
Lagunas, Esther
Ramchandani, Bunty
García-Bouza, Mónica
Nieto, María Luisa
Cachofeiro Ramos, María Victoria
author_role author
author2 Ortega-Hernández, Adriana
Martínez Martínez, Ernesto
Jurado-López, Raquel
Luaces, María
Islas, Fabian
Gómez-Garre, Dulcenombre
Lagunas, Esther
Ramchandani, Bunty
García-Bouza, Mónica
Nieto, María Luisa
Cachofeiro Ramos, María Victoria
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616-056.25
cardiac lipotoxicity
miRNAs
myocardial infarction
obesity
Ciencias Biomédicas
32 Ciencias Médicas
topic 616-056.25
cardiac lipotoxicity
miRNAs
myocardial infarction
obesity
Ciencias Biomédicas
32 Ciencias Médicas
description Cardiac lipotoxicity is involved in the cardiac functional consequences associated with obesity. Therefore, the aim of this study was to explore whether changes in the mitochondrial lipid cardiac profle could refect diferences in cardiac function and structure in obese and non-obese rats with myocardial infarction (MI). Whether these changes can also be refected in a specifc plasma miRNA signature as markers of cardiac damage was also evaluated. Rats were fed with either standard (3.5% fat) or high fat diet (35% fat) for 6 weeks before the induction of MI and sacrifced 4 weeks later. MI showed cardiac lipotoxicity independently of the presence of obesity, although obese and non-obese rats did not present the same cardiac lipid profle at mitochondrial level. Several cardiac lipid species in mitochondria, including cardiolipins and triglycerides, were associated with myocardial fbrosis, with mitochondrial triglyceride levels being independently associated with it; this supports that lipotoxicity can afect cardiac function. MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese and non-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardial fbrosis, with miRNA 15b-5p levels being independently associated with cardiac fbrosis. This could support that lipotoxicity could afect heart function by modulating plasma miRNAs.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/115420
url https://hdl.handle.net/20.500.14352/115420
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Portfolio
publisher.none.fl_str_mv Nature Portfolio
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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