Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)

Gastrointestinal Stromal Tumours (GISTs) are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this research field is broad and the body of evidence is scattered and expanding. Our objectives are...

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Authors: Ballesteros Silva, Mónica Patricia|||0000-0001-5244-4795, Montero, Nadia|||0000-0002-5375-3781, López Pousa, Antonio, Urrútia, Gerard|||0000-0002-8850-0960, Solà Arnau, Ivan|||0000-0003-0078-3706, Rada, Gabriel|||0000-0003-2435-0710, Pardo-Hernandez, Hector|||0000-0003-3714-0309, Bonfill, X. (Xavier)|||0000-0003-1530-3509
Format: article
Publication Date:2017
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:186323
Online Access:https://ddd.uab.cat/record/186323
https://dx.doi.org/urn:doi:10.1186/s12874-017-0402-9
Access Level:Open access
Keyword:GIST
Gastrointestinal Stromal Tumours
Evidence mapping
Evidence synthesis
Global evidence mapping
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spelling Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)Ballesteros Silva, Mónica Patricia|||0000-0001-5244-4795Montero, Nadia|||0000-0002-5375-3781López Pousa, AntonioUrrútia, Gerard|||0000-0002-8850-0960Solà Arnau, Ivan|||0000-0003-0078-3706Rada, Gabriel|||0000-0003-2435-0710Pardo-Hernandez, Hector|||0000-0003-3714-0309Bonfill, X. (Xavier)|||0000-0003-1530-3509GISTGastrointestinal Stromal TumoursEvidence mappingEvidence synthesisGlobal evidence mappingGastrointestinal Stromal Tumours (GISTs) are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this research field is broad and the body of evidence is scattered and expanding. Our objectives are to identify, describe and organise the current available evidence for GIST through an evidence mapping approach. We followed the methodology of Global Evidence Mapping (GEM). We searched Pubmed, EMBASE, The Cochrane Library and Epistemonikos in order to identify systematic reviews (SRs) with or without meta-analyses published between 1990 and March 2016. Two authors assessed eligibility and extracted data. Methodological quality of the included systematic reviews was assessed using AMSTAR. We organised the results according to identified PICO questions and presented the evidence map in tables and a bubble plot. A total of 17 SRs met eligibility criteria. These reviews included 66 individual studies, of which three quarters were either observational or uncontrolled clinical trials. Overall, the quality of the included SRs was moderate or high. In total, we extracted 14 PICO questions from them and the corresponding results mostly favoured the intervention arm. The most common type of study used to evaluate therapeutic interventions in GIST sarcomas has been non-experimental studies. However, the majority of the interventions are reported as beneficial or probably beneficial by the respective authors of SRs. The evidence mapping is a useful and reliable methodology to identify and present the existing evidence about therapeutic interventions. The online version of this article (doi:10.1186/s12874-017-0402-9) contains supplementary material, which is available to authorized users.Universitat Autònoma de Barcelona 22017-01-0120172017-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/186323https://dx.doi.org/urn:doi:10.1186/s12874-017-0402-9reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1863232026-06-06T12:50:31Z
dc.title.none.fl_str_mv Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)
title Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)
spellingShingle Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)
Ballesteros Silva, Mónica Patricia|||0000-0001-5244-4795
GIST
Gastrointestinal Stromal Tumours
Evidence mapping
Evidence synthesis
Global evidence mapping
title_short Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)
title_full Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)
title_fullStr Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)
title_full_unstemmed Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)
title_sort Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST)
dc.creator.none.fl_str_mv Ballesteros Silva, Mónica Patricia|||0000-0001-5244-4795
Montero, Nadia|||0000-0002-5375-3781
López Pousa, Antonio
Urrútia, Gerard|||0000-0002-8850-0960
Solà Arnau, Ivan|||0000-0003-0078-3706
Rada, Gabriel|||0000-0003-2435-0710
Pardo-Hernandez, Hector|||0000-0003-3714-0309
Bonfill, X. (Xavier)|||0000-0003-1530-3509
author Ballesteros Silva, Mónica Patricia|||0000-0001-5244-4795
author_facet Ballesteros Silva, Mónica Patricia|||0000-0001-5244-4795
Montero, Nadia|||0000-0002-5375-3781
López Pousa, Antonio
Urrútia, Gerard|||0000-0002-8850-0960
Solà Arnau, Ivan|||0000-0003-0078-3706
Rada, Gabriel|||0000-0003-2435-0710
Pardo-Hernandez, Hector|||0000-0003-3714-0309
Bonfill, X. (Xavier)|||0000-0003-1530-3509
author_role author
author2 Montero, Nadia|||0000-0002-5375-3781
López Pousa, Antonio
Urrútia, Gerard|||0000-0002-8850-0960
Solà Arnau, Ivan|||0000-0003-0078-3706
Rada, Gabriel|||0000-0003-2435-0710
Pardo-Hernandez, Hector|||0000-0003-3714-0309
Bonfill, X. (Xavier)|||0000-0003-1530-3509
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv GIST
Gastrointestinal Stromal Tumours
Evidence mapping
Evidence synthesis
Global evidence mapping
topic GIST
Gastrointestinal Stromal Tumours
Evidence mapping
Evidence synthesis
Global evidence mapping
description Gastrointestinal Stromal Tumours (GISTs) are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this research field is broad and the body of evidence is scattered and expanding. Our objectives are to identify, describe and organise the current available evidence for GIST through an evidence mapping approach. We followed the methodology of Global Evidence Mapping (GEM). We searched Pubmed, EMBASE, The Cochrane Library and Epistemonikos in order to identify systematic reviews (SRs) with or without meta-analyses published between 1990 and March 2016. Two authors assessed eligibility and extracted data. Methodological quality of the included systematic reviews was assessed using AMSTAR. We organised the results according to identified PICO questions and presented the evidence map in tables and a bubble plot. A total of 17 SRs met eligibility criteria. These reviews included 66 individual studies, of which three quarters were either observational or uncontrolled clinical trials. Overall, the quality of the included SRs was moderate or high. In total, we extracted 14 PICO questions from them and the corresponding results mostly favoured the intervention arm. The most common type of study used to evaluate therapeutic interventions in GIST sarcomas has been non-experimental studies. However, the majority of the interventions are reported as beneficial or probably beneficial by the respective authors of SRs. The evidence mapping is a useful and reliable methodology to identify and present the existing evidence about therapeutic interventions. The online version of this article (doi:10.1186/s12874-017-0402-9) contains supplementary material, which is available to authorized users.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/186323
https://dx.doi.org/urn:doi:10.1186/s12874-017-0402-9
url https://ddd.uab.cat/record/186323
https://dx.doi.org/urn:doi:10.1186/s12874-017-0402-9
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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