Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition

In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organization, we used the paradigm of environmental enrich...

ver descrição completa

Detalhes bibliográficos
Autores: Espeso Gil, Sergio, Holik, Aliaksei Z., Bonnin, Sarah, Jhanwar, Shalu, Chandrasekaran, Sandhya, Pique Regi, Roger, Albaigès, Júlia, Maher, Michael, Permanyer, Jon, Irimia Martínez, Manuel, Friedländer, Marc R., Pons Espinal, Meritxell, Akbarian, Schahram, Dierssen, Mara, Maass, Philipp, Hor, Charlotte N., Ossowski, Stephan
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/178235
Acesso em linha:https://hdl.handle.net/2445/178235
Access Level:acceso abierto
Palavra-chave:Epigenètica
Cognició
Epigenetics
Cognition
Descrição
Resumo:In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organization, we used the paradigm of environmental enrichment (EE) in young mice constantly receiving novel stimulation. We profiled epigenome and chromatin architecture in whole cortex and sorted neurons by deep-sequencing techniques. Specifically, we studied chromatin accessibility, gene and protein regulation, and 3D genome conformation, combined with predicted enhancer and chromatin interactions. We identified increased chromatin accessibility, transcription factor binding including CTCF-mediated insulation, differential occupancy of H3K36me3 and H3K79me2, and changes in transcriptional programs required for neuronal development. EE stimuli led to local genome re-organization by inducing increased contacts between chromosomes 7 and 17 (inter-chromosomal). Our findings support the notion that EE-induced learning and memory processes are directly associated with the epigenome and genome organization.

Registos relacionados