Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology
Adenosine, hypoxanthine, xanthine, guanosine, and inosine levels were assessed by HPLC, and the activity of related enzymes 5'-nucleotidase (5'-NT), adenosine deaminase (ADA), and purine nucleoside phosphorylase (PNP) measured in frontal (FC), parietal (PC) and temporal (TC) cortices at di...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/140360 |
| Acceso en línea: | https://hdl.handle.net/2445/140360 |
| Access Level: | acceso abierto |
| Palabra clave: | Malaltia d'Alzheimer Enzimologia Lòbul frontal Lòbul temporal Metabolisme Purines Alzheimer's disease Enzymology Frontal lobe Temporal lobe Metabolism |
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Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathologyAlonso-Andrés, PatriciaAlbasanz, José LuisFerrer, Isidro (Ferrer Abizanda)Martín, MairenaMalaltia d'AlzheimerEnzimologiaLòbul frontalLòbul temporalMetabolismePurinesAlzheimer's diseaseEnzymologyFrontal lobeTemporal lobeMetabolismPurinesAdenosine, hypoxanthine, xanthine, guanosine, and inosine levels were assessed by HPLC, and the activity of related enzymes 5'-nucleotidase (5'-NT), adenosine deaminase (ADA), and purine nucleoside phosphorylase (PNP) measured in frontal (FC), parietal (PC) and temporal (TC) cortices at different stages of disease progression in Alzheimer's disease (AD) and in age-matched controls. Significantly decreased levels of adenosine, guanosine, hypoxanthine, and xanthine, and apparently less inosine, are found in FC from the early stages of AD; PC and TC show an opposing pattern, as adenosine, guanosine, and inosine are significantly increased at least at determinate stages of AD whereas hypoxanthine and xanthine levels remain unaltered. 5'-NT is reduced in membranes and cytosol in FC mainly at early stages but not in PC, and only at advanced stages in cytosol in TC. ADA activity is decreased in AD when considered as a whole but increased at early stages in TC. Finally, PNP activity is increased only in TC at early stages. Purine metabolism alterations occur at early stages of AD independently of neurofibrillary tangles and β-amyloid plaques. Alterations are stage- and regiondependent, the latter showing opposite patterns in FC compared with PC and TC. Adenosine is the most affected of the assessed purines. Key words: Adenosine, Alzheimer's disease, cerebral cortex, purine metabolism.Wiley2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/140360Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1111/bpa.12592Brain Pathology, 2018, vol. 28, num. 6, p. 933-946https://doi.org/10.1111/bpa.12592(c) International Society of Neuropathology, 2018info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1403602026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology |
| title |
Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology |
| spellingShingle |
Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology Alonso-Andrés, Patricia Malaltia d'Alzheimer Enzimologia Lòbul frontal Lòbul temporal Metabolisme Purines Alzheimer's disease Enzymology Frontal lobe Temporal lobe Metabolism Purines |
| title_short |
Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology |
| title_full |
Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology |
| title_fullStr |
Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology |
| title_full_unstemmed |
Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology |
| title_sort |
Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology |
| dc.creator.none.fl_str_mv |
Alonso-Andrés, Patricia Albasanz, José Luis Ferrer, Isidro (Ferrer Abizanda) Martín, Mairena |
| author |
Alonso-Andrés, Patricia |
| author_facet |
Alonso-Andrés, Patricia Albasanz, José Luis Ferrer, Isidro (Ferrer Abizanda) Martín, Mairena |
| author_role |
author |
| author2 |
Albasanz, José Luis Ferrer, Isidro (Ferrer Abizanda) Martín, Mairena |
| author2_role |
author author author |
| dc.subject.none.fl_str_mv |
Malaltia d'Alzheimer Enzimologia Lòbul frontal Lòbul temporal Metabolisme Purines Alzheimer's disease Enzymology Frontal lobe Temporal lobe Metabolism Purines |
| topic |
Malaltia d'Alzheimer Enzimologia Lòbul frontal Lòbul temporal Metabolisme Purines Alzheimer's disease Enzymology Frontal lobe Temporal lobe Metabolism Purines |
| description |
Adenosine, hypoxanthine, xanthine, guanosine, and inosine levels were assessed by HPLC, and the activity of related enzymes 5'-nucleotidase (5'-NT), adenosine deaminase (ADA), and purine nucleoside phosphorylase (PNP) measured in frontal (FC), parietal (PC) and temporal (TC) cortices at different stages of disease progression in Alzheimer's disease (AD) and in age-matched controls. Significantly decreased levels of adenosine, guanosine, hypoxanthine, and xanthine, and apparently less inosine, are found in FC from the early stages of AD; PC and TC show an opposing pattern, as adenosine, guanosine, and inosine are significantly increased at least at determinate stages of AD whereas hypoxanthine and xanthine levels remain unaltered. 5'-NT is reduced in membranes and cytosol in FC mainly at early stages but not in PC, and only at advanced stages in cytosol in TC. ADA activity is decreased in AD when considered as a whole but increased at early stages in TC. Finally, PNP activity is increased only in TC at early stages. Purine metabolism alterations occur at early stages of AD independently of neurofibrillary tangles and β-amyloid plaques. Alterations are stage- and regiondependent, the latter showing opposite patterns in FC compared with PC and TC. Adenosine is the most affected of the assessed purines. Key words: Adenosine, Alzheimer's disease, cerebral cortex, purine metabolism. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/140360 |
| url |
https://hdl.handle.net/2445/140360 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1111/bpa.12592 Brain Pathology, 2018, vol. 28, num. 6, p. 933-946 https://doi.org/10.1111/bpa.12592 |
| dc.rights.none.fl_str_mv |
(c) International Society of Neuropathology, 2018 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) International Society of Neuropathology, 2018 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley |
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Wiley |
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Articles publicats en revistes (Patologia i Terapèutica Experimental) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
| reponame_str |
Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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15,301603 |