Genetics and epigenetics of spontaneous intracerebral hemorrhage

Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlob...

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Authors: Giralt-Steinhauer, Eva, Jiménez-Balado, Joan, Fernández-Pérez, Isabel, Rey Álvarez, Lucía, Rodríguez-Campello, Ana, Ois Santiago, Angel Javier, Cuadrado-Godia, Elisa, Jiménez Conde, Jordi, Roquer, Jaume
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/55491
Online Access:http://hdl.handle.net/10230/55491
http://dx.doi.org/10.3390/ijms23126479
Access Level:Open access
Keyword:Epigenetics
Genetics
Intracerebral hemorrhage
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spelling Genetics and epigenetics of spontaneous intracerebral hemorrhageGiralt-Steinhauer, EvaJiménez-Balado, JoanFernández-Pérez, IsabelRey Álvarez, LucíaRodríguez-Campello, AnaOis Santiago, Angel JavierCuadrado-Godia, ElisaJiménez Conde, JordiRoquer, JaumeEpigeneticsGeneticsIntracerebral hemorrhageIntracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.MDPI202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55491http://dx.doi.org/10.3390/ijms23126479reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInt J Mol Sci. 2022 Jun 9;23(12):6479© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/554912026-05-29T05:05:01Z
dc.title.none.fl_str_mv Genetics and epigenetics of spontaneous intracerebral hemorrhage
title Genetics and epigenetics of spontaneous intracerebral hemorrhage
spellingShingle Genetics and epigenetics of spontaneous intracerebral hemorrhage
Giralt-Steinhauer, Eva
Epigenetics
Genetics
Intracerebral hemorrhage
title_short Genetics and epigenetics of spontaneous intracerebral hemorrhage
title_full Genetics and epigenetics of spontaneous intracerebral hemorrhage
title_fullStr Genetics and epigenetics of spontaneous intracerebral hemorrhage
title_full_unstemmed Genetics and epigenetics of spontaneous intracerebral hemorrhage
title_sort Genetics and epigenetics of spontaneous intracerebral hemorrhage
dc.creator.none.fl_str_mv Giralt-Steinhauer, Eva
Jiménez-Balado, Joan
Fernández-Pérez, Isabel
Rey Álvarez, Lucía
Rodríguez-Campello, Ana
Ois Santiago, Angel Javier
Cuadrado-Godia, Elisa
Jiménez Conde, Jordi
Roquer, Jaume
author Giralt-Steinhauer, Eva
author_facet Giralt-Steinhauer, Eva
Jiménez-Balado, Joan
Fernández-Pérez, Isabel
Rey Álvarez, Lucía
Rodríguez-Campello, Ana
Ois Santiago, Angel Javier
Cuadrado-Godia, Elisa
Jiménez Conde, Jordi
Roquer, Jaume
author_role author
author2 Jiménez-Balado, Joan
Fernández-Pérez, Isabel
Rey Álvarez, Lucía
Rodríguez-Campello, Ana
Ois Santiago, Angel Javier
Cuadrado-Godia, Elisa
Jiménez Conde, Jordi
Roquer, Jaume
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Epigenetics
Genetics
Intracerebral hemorrhage
topic Epigenetics
Genetics
Intracerebral hemorrhage
description Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/55491
http://dx.doi.org/10.3390/ijms23126479
url http://hdl.handle.net/10230/55491
http://dx.doi.org/10.3390/ijms23126479
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Int J Mol Sci. 2022 Jun 9;23(12):6479
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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