Growth arrest is a DNA damage protection strategy in Arabidopsis

[EN] When exposed to stress, plants reduce growth while activating defense mechanisms-a behaviour proposed to help reallocate resources and meet the energy demands required for survival. Here, we have challenged this view by mutating the cyclin-dependent kinase inhibitor SMR1 to reverse the growth a...

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Authors: Serrano Mislata, Antonio|||0000-0002-8828-1809, Blanco-Touriñán, Noel|||0000-0003-4610-6110, Silvia, Urbez Lagunas, Cristina|||0000-0001-9345-7322, ALABADÍ DIEGO, DAVID|||0000-0001-8492-6713, BLAZQUEZ, MIGUEL-ANGEL|||0000-0001-5743-0448, Hernández-García, Jorge, de Ollas, Carlos, Gómez-Cadenas, Aurelio, Sablowski, Robert
Format: article
Publication Date:2025
Country:España
Institution:Universitat Politècnica de València (UPV)
Repository:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Language:English
OAI Identifier:oai:riunet.upv.es:10251/225951
Online Access:https://riunet.upv.es/handle/10251/225951
Access Level:Open access
Keyword:Arabidopsis
DNA damage
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Growth arrest is a DNA damage protection strategy in Arabidopsis
title Growth arrest is a DNA damage protection strategy in Arabidopsis
spellingShingle Growth arrest is a DNA damage protection strategy in Arabidopsis
Serrano Mislata, Antonio|||0000-0002-8828-1809
Arabidopsis
DNA damage
title_short Growth arrest is a DNA damage protection strategy in Arabidopsis
title_full Growth arrest is a DNA damage protection strategy in Arabidopsis
title_fullStr Growth arrest is a DNA damage protection strategy in Arabidopsis
title_full_unstemmed Growth arrest is a DNA damage protection strategy in Arabidopsis
title_sort Growth arrest is a DNA damage protection strategy in Arabidopsis
dc.creator.none.fl_str_mv Serrano Mislata, Antonio|||0000-0002-8828-1809
Blanco-Touriñán, Noel|||0000-0003-4610-6110
Silvia
Urbez Lagunas, Cristina|||0000-0001-9345-7322
ALABADÍ DIEGO, DAVID|||0000-0001-8492-6713
BLAZQUEZ, MIGUEL-ANGEL|||0000-0001-5743-0448
Hernández-García, Jorge
de Ollas, Carlos
Gómez-Cadenas, Aurelio
Sablowski, Robert
author Serrano Mislata, Antonio|||0000-0002-8828-1809
author_facet Serrano Mislata, Antonio|||0000-0002-8828-1809
Blanco-Touriñán, Noel|||0000-0003-4610-6110
Silvia
Urbez Lagunas, Cristina|||0000-0001-9345-7322
ALABADÍ DIEGO, DAVID|||0000-0001-8492-6713
BLAZQUEZ, MIGUEL-ANGEL|||0000-0001-5743-0448
Hernández-García, Jorge
de Ollas, Carlos
Gómez-Cadenas, Aurelio
Sablowski, Robert
author_role author
author2 Blanco-Touriñán, Noel|||0000-0003-4610-6110
Silvia
Urbez Lagunas, Cristina|||0000-0001-9345-7322
ALABADÍ DIEGO, DAVID|||0000-0001-8492-6713
BLAZQUEZ, MIGUEL-ANGEL|||0000-0001-5743-0448
Hernández-García, Jorge
de Ollas, Carlos
Gómez-Cadenas, Aurelio
Sablowski, Robert
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto Universitario Mixto de Biología Molecular y Celular de Plantas
European Commission
Generalitat Valenciana
UK Research and Innovation
Agencia Estatal de Investigación
European Regional Development Fund
Ministerio de Ciencia e Innovación
Biotechnology and Biological Sciences Research Council, Reino Unido
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Arabidopsis
DNA damage
topic Arabidopsis
DNA damage
description [EN] When exposed to stress, plants reduce growth while activating defense mechanisms-a behaviour proposed to help reallocate resources and meet the energy demands required for survival. Here, we have challenged this view by mutating the cyclin-dependent kinase inhibitor SMR1 to reverse the growth arrest imposed by high DELLA levels. These plants continue growing under limited water availability but maintain the same oxidative stress tolerance and survival rates as the parental line that halted growth. However, shoot and root meristematic cells that keep dividing under drought or genotoxic stress accumulate DNA damage, frequently leading to cell death. Since the DNA lesions are observed in the apical stem cells that give rise to all plant organs, including flowers, we propose that systemic growth arrest acts as a defense strategy that plants employ not only to maximize individual fitness, but also to ensure the accurate transmission of genetic information to their progeny.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-07-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/225951
url https://riunet.upv.es/handle/10251/225951
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-109925GB-I00 PAPEL DE LAS PREFOLDIN-LIKE EN SEÑALIZACION AMBIENTAL Y HOMEOSTASIS DE PROTEINAS EN ARABIDOPSIS
Ministerio de Ciencia e Innovación Ministerio de Ciencia e Innovación PID2022-141770NB-I00 Evolución específica de linaje de la regulación por luz y temperatura en las plantas terrestres [LISPEVOL]
Ministerio de Ciencia e Innovación Ministerio de Ciencia e Innovación PID2022-137859OB-I00 Characterization of the activity of the shoot apical meristem under drought stress (ThirstyCells)
European Commission https://doi.org/10.13039/501100000780 H2020-MSCA-IF-2016-746396
Generalitat Valenciana https://doi.org/10.13039/501100003359 CISEJI%2F2022%2F28
Generalitat Valenciana https://doi.org/10.13039/501100003359 CIPROM%2F2022%2F7
Generalitat Valenciana https://doi.org/10.13039/501100003359 CIAICO%2F2021%2F063
UK Research and Innovation https://doi.org/10.13039/100014013 EP%2FX034550%2F1
Biotechnological Science Research Council, Reino Unido https://doi.org/10.13039/501100000268 BB%2FX01102X%2F1
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Growth arrest is a DNA damage protection strategy in ArabidopsisSerrano Mislata, Antonio|||0000-0002-8828-1809Blanco-Touriñán, Noel|||0000-0003-4610-6110SilviaUrbez Lagunas, Cristina|||0000-0001-9345-7322ALABADÍ DIEGO, DAVID|||0000-0001-8492-6713BLAZQUEZ, MIGUEL-ANGEL|||0000-0001-5743-0448Hernández-García, Jorgede Ollas, CarlosGómez-Cadenas, AurelioSablowski, RobertArabidopsisDNA damage[EN] When exposed to stress, plants reduce growth while activating defense mechanisms-a behaviour proposed to help reallocate resources and meet the energy demands required for survival. Here, we have challenged this view by mutating the cyclin-dependent kinase inhibitor SMR1 to reverse the growth arrest imposed by high DELLA levels. These plants continue growing under limited water availability but maintain the same oxidative stress tolerance and survival rates as the parental line that halted growth. However, shoot and root meristematic cells that keep dividing under drought or genotoxic stress accumulate DNA damage, frequently leading to cell death. Since the DNA lesions are observed in the apical stem cells that give rise to all plant organs, including flowers, we propose that systemic growth arrest acts as a defense strategy that plants employ not only to maximize individual fitness, but also to ensure the accurate transmission of genetic information to their progeny.This research has been carried out thanks to grants PID2019-109925GB-I00 (to D.A.), PID2022-141770NB (to M.A.B.) and PID2022-137859OB-I00 (to A.S-M.) funded by the Spanish MICIN/AEI/10.13039/501100011033/ and by "ERDF, A way of making Europe". A.S-M. was also funded by the EU-MSCA program (H2020-MSCA-IF-2016-746396) and the Generalitat Valenciana Plan GenT and Prometeo programs (CISEJI/2022/28 and CIPROM/2022/7). Research in R.S. group was funded by BSRC grant BB/X01102X/1 and UKRI Frontier Research Grant EP/X034550/1. Research in A.G-C. group was funded by the Generalitat Valenciana grant CIAICO/2021/063.Nature Publishing GroupInstituto Universitario Mixto de Biología Molecular y Celular de PlantasEuropean CommissionGeneralitat ValencianaUK Research and InnovationAgencia Estatal de InvestigaciónEuropean Regional Development FundMinisterio de Ciencia e InnovaciónBiotechnology and Biological Sciences Research Council, Reino UnidoRepositorio Institucional de la Universitat Politècnica de València Riunet20252025-07-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/225951reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-109925GB-I00 PAPEL DE LAS PREFOLDIN-LIKE EN SEÑALIZACION AMBIENTAL Y HOMEOSTASIS DE PROTEINAS EN ARABIDOPSISMinisterio de Ciencia e Innovación Ministerio de Ciencia e Innovación PID2022-141770NB-I00 Evolución específica de linaje de la regulación por luz y temperatura en las plantas terrestres [LISPEVOL]Ministerio de Ciencia e Innovación Ministerio de Ciencia e Innovación PID2022-137859OB-I00 Characterization of the activity of the shoot apical meristem under drought stress (ThirstyCells)European Commission https://doi.org/10.13039/501100000780 H2020-MSCA-IF-2016-746396Generalitat Valenciana https://doi.org/10.13039/501100003359 CISEJI%2F2022%2F28Generalitat Valenciana https://doi.org/10.13039/501100003359 CIPROM%2F2022%2F7Generalitat Valenciana https://doi.org/10.13039/501100003359 CIAICO%2F2021%2F063UK Research and Innovation https://doi.org/10.13039/100014013 EP%2FX034550%2F1Biotechnological Science Research Council, Reino Unido https://doi.org/10.13039/501100000268 BB%2FX01102X%2F1open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2259512026-06-13T07:49:27Z
score 15,811543

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