Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex

BACKGROUND. A long-held goal of vision therapy is to transfer information directly to the visual cortex of blind individuals, thereby restoring a rudimentary form of sight. However, no clinically available cortical visual prosthesis yet exists. METHODS. We implanted an intracortical microelectrode a...

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Autores: Fernandez, E, Alfaro, A, Soto-Sanchez, C, Gonzalez-Lopez, P, Lozano, AM, Pena, S, Grima, MD, Rodil, A, Gomez, B, Chen, X, Roelfsema, PR, Rolston, JD, Davis, TS, Normann, RA
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p7566
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones7566
Access Level:acceso abierto
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spelling Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortexFernandez, EAlfaro, ASoto-Sanchez, CGonzalez-Lopez, PLozano, AMPena, SGrima, MDRodil, AGomez, BChen, XRoelfsema, PRRolston, JDDavis, TSNormann, RABACKGROUND. A long-held goal of vision therapy is to transfer information directly to the visual cortex of blind individuals, thereby restoring a rudimentary form of sight. However, no clinically available cortical visual prosthesis yet exists. METHODS. We implanted an intracortical microelectrode array consisting of 96 electrodes in the visual cortex of a 57-year-old person with complete blindness for a 6-month period. We measured thresholds and the characteristics of the visual percepts elicited by intracortical microstimulation. RESULTS. Implantation and subsequent explantation of intracortical microelectrodes were carried out without complications. The mean stimulation threshold for single electrodes was 66.8 +/- 36.5 IAA. We consistently obtained high-quality recordings from visually deprived neurons and the stimulation parameters remained stable over time. Simultaneous stimulation via multiple electrodes was associated with a significant reduction in thresholds (P < 0.001, ANOVA) and evoked discriminable phosphene percepts, allowing the blind participant to identify some letters and recognize object boundaries. CONCLUSIONS. Our results demonstrate the safety and efficacy of chronic intracortical microstimulation via a large number of electrodes in human visual cortex, showing its high potential for restoring functional vision in the blind. TRIAL REGISTRATION. ClinicalTrials.gov identifier NCT02983370.AMER SOC CLINICAL INVESTIGATION INC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones7566JOURNAL OF CLINICAL INVESTIGATIONISSN: 00219738ISSNe: 15588238reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p75662026-06-12T10:20:37Z
dc.title.none.fl_str_mv Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex
title Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex
spellingShingle Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex
Fernandez, E
title_short Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex
title_full Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex
title_fullStr Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex
title_full_unstemmed Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex
title_sort Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex
dc.creator.none.fl_str_mv Fernandez, E
Alfaro, A
Soto-Sanchez, C
Gonzalez-Lopez, P
Lozano, AM
Pena, S
Grima, MD
Rodil, A
Gomez, B
Chen, X
Roelfsema, PR
Rolston, JD
Davis, TS
Normann, RA
author Fernandez, E
author_facet Fernandez, E
Alfaro, A
Soto-Sanchez, C
Gonzalez-Lopez, P
Lozano, AM
Pena, S
Grima, MD
Rodil, A
Gomez, B
Chen, X
Roelfsema, PR
Rolston, JD
Davis, TS
Normann, RA
author_role author
author2 Alfaro, A
Soto-Sanchez, C
Gonzalez-Lopez, P
Lozano, AM
Pena, S
Grima, MD
Rodil, A
Gomez, B
Chen, X
Roelfsema, PR
Rolston, JD
Davis, TS
Normann, RA
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
description BACKGROUND. A long-held goal of vision therapy is to transfer information directly to the visual cortex of blind individuals, thereby restoring a rudimentary form of sight. However, no clinically available cortical visual prosthesis yet exists. METHODS. We implanted an intracortical microelectrode array consisting of 96 electrodes in the visual cortex of a 57-year-old person with complete blindness for a 6-month period. We measured thresholds and the characteristics of the visual percepts elicited by intracortical microstimulation. RESULTS. Implantation and subsequent explantation of intracortical microelectrodes were carried out without complications. The mean stimulation threshold for single electrodes was 66.8 +/- 36.5 IAA. We consistently obtained high-quality recordings from visually deprived neurons and the stimulation parameters remained stable over time. Simultaneous stimulation via multiple electrodes was associated with a significant reduction in thresholds (P < 0.001, ANOVA) and evoked discriminable phosphene percepts, allowing the blind participant to identify some letters and recognize object boundaries. CONCLUSIONS. Our results demonstrate the safety and efficacy of chronic intracortical microstimulation via a large number of electrodes in human visual cortex, showing its high potential for restoring functional vision in the blind. TRIAL REGISTRATION. ClinicalTrials.gov identifier NCT02983370.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones7566
url https://isabial.portalinvestigacion.com/publicaciones7566
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv AMER SOC CLINICAL INVESTIGATION INC
publisher.none.fl_str_mv AMER SOC CLINICAL INVESTIGATION INC
dc.source.none.fl_str_mv JOURNAL OF CLINICAL INVESTIGATION
ISSN: 00219738
ISSNe: 15588238
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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