Sonic hedgehog specifies flight feather positional information in avian wings

Classical tissue recombination experiments performed in the chick embryo provide evidence that signals operating during early limb development specify the position and identity of feathers. Here, we show that Sonic hedgehog (Shh) signalling in the embryonic chick wing bud specifies positional inform...

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Detalles Bibliográficos
Autores: Busby, Lara, Aceituno, Cristina, McQueen, Caitlin, Rich, Constance A., Ros, María A., Towers, Matthew
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/223693
Acceso en línea:http://hdl.handle.net/10261/223693
Access Level:acceso abierto
Palabra clave:Avian
Chicks
Embryo
Flight feather
Positional information
Shh
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repository_id_str
spelling Sonic hedgehog specifies flight feather positional information in avian wingsBusby, LaraAceituno, CristinaMcQueen, CaitlinRich, Constance A.Ros, María A.Towers, MatthewAvianChicksEmbryoFlight featherPositional informationShhClassical tissue recombination experiments performed in the chick embryo provide evidence that signals operating during early limb development specify the position and identity of feathers. Here, we show that Sonic hedgehog (Shh) signalling in the embryonic chick wing bud specifies positional information required for the formation of adult flight feathers in a defined spatial and temporal sequence that reflects their different identities. We also reveal that Shh signalling is interpreted into specific patterns of Sim1 and Zic transcription factor expression, providing evidence of a putative gene regulatory network operating in flight feather patterning. Our data suggest that flight feather specification involved the co-option of the pre-existing digit patterning mechanism and therefore uncovers an embryonic process that played a fundamental step in the evolution of avian flight.M.T. thanks the Wellcome Trust for funding (202756/Z/16/Z) and M.A.R. thanks the Spanish Ministerio de Ciencia, Innovación y Universidades (BFU2017-88265-P). Deposited in PMC for immediate release.Company of BiologistsWellcome TrustMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/223693reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-88265-PBFU2017-88265-P/AEI/10.13039/501100011033http://dx.doi.org/10.1242/dev.188821Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2236932026-05-22T06:33:51Z
dc.title.none.fl_str_mv Sonic hedgehog specifies flight feather positional information in avian wings
title Sonic hedgehog specifies flight feather positional information in avian wings
spellingShingle Sonic hedgehog specifies flight feather positional information in avian wings
Busby, Lara
Avian
Chicks
Embryo
Flight feather
Positional information
Shh
title_short Sonic hedgehog specifies flight feather positional information in avian wings
title_full Sonic hedgehog specifies flight feather positional information in avian wings
title_fullStr Sonic hedgehog specifies flight feather positional information in avian wings
title_full_unstemmed Sonic hedgehog specifies flight feather positional information in avian wings
title_sort Sonic hedgehog specifies flight feather positional information in avian wings
dc.creator.none.fl_str_mv Busby, Lara
Aceituno, Cristina
McQueen, Caitlin
Rich, Constance A.
Ros, María A.
Towers, Matthew
author Busby, Lara
author_facet Busby, Lara
Aceituno, Cristina
McQueen, Caitlin
Rich, Constance A.
Ros, María A.
Towers, Matthew
author_role author
author2 Aceituno, Cristina
McQueen, Caitlin
Rich, Constance A.
Ros, María A.
Towers, Matthew
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Wellcome Trust
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Avian
Chicks
Embryo
Flight feather
Positional information
Shh
topic Avian
Chicks
Embryo
Flight feather
Positional information
Shh
description Classical tissue recombination experiments performed in the chick embryo provide evidence that signals operating during early limb development specify the position and identity of feathers. Here, we show that Sonic hedgehog (Shh) signalling in the embryonic chick wing bud specifies positional information required for the formation of adult flight feathers in a defined spatial and temporal sequence that reflects their different identities. We also reveal that Shh signalling is interpreted into specific patterns of Sim1 and Zic transcription factor expression, providing evidence of a putative gene regulatory network operating in flight feather patterning. Our data suggest that flight feather specification involved the co-option of the pre-existing digit patterning mechanism and therefore uncovers an embryonic process that played a fundamental step in the evolution of avian flight.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/223693
url http://hdl.handle.net/10261/223693
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-88265-P
BFU2017-88265-P/AEI/10.13039/501100011033
http://dx.doi.org/10.1242/dev.188821
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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