Effects of Moringa oleifera Lam. supplementation on inflammatory and cardiometabolic markers in subjects with prediabetes

This article belongs to the Special Issue Obesity and Inflammation: The Role of Nutrition and Diet.

Detalles Bibliográficos
Autores: Díaz-Prieto, Ligia E., Gómez-Martínez, Sonia, Vicente-Castro, Iván, Heredia-Díaz, Carlos, Gónzalez Romero, Elena Aurora, Martín-Ridaura, Carmen, Ceinos, Mercedes, Picón, María J., Marcos, Ascensión, Nova, Esther
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/268981
Acceso en línea:http://hdl.handle.net/10261/268981
Access Level:acceso abierto
Palabra clave:Moringa oleifera Lam.
Serum lipid profile
Food supplement
Inflammatory markers
Prediabetes
Glycemic control
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spelling Effects of Moringa oleifera Lam. supplementation on inflammatory and cardiometabolic markers in subjects with prediabetesDíaz-Prieto, Ligia E.Gómez-Martínez, SoniaVicente-Castro, IvánHeredia-Díaz, CarlosGónzalez Romero, Elena AuroraMartín-Ridaura, CarmenCeinos, MercedesPicón, María J.Marcos, AscensiónNova, EstherMoringa oleifera Lam.Serum lipid profileFood supplementInflammatory markersPrediabetesGlycemic controlThis article belongs to the Special Issue Obesity and Inflammation: The Role of Nutrition and Diet.Different parts of the Moringa oleifera Lam. (MO) tree are consumed as food or food supplements for their nutritional and medicinal value; however, very few human studies have been published on the topic. The current work was aimed to provide ancillary analysis to the antidiabetic effects previously reported in a double-blind, randomized, placebo-controlled, parallel group intervention conducted in patients with prediabetes. Thus, the effect of MO leaves on blood and fecal inflammatory markers, serum lipid profile, plasma antioxidant capacity and blood pressure was studied in participants who consumed 6 × 400 mg capsule/day of MO dry leaf powder (MO, n = 31) or placebo (PLC, n = 34) over 12 weeks. Differences between groups were assessed using each biomarker’s change score with, adjustment for fat status and the baseline value. In addition, a decision tree analysis was performed to find individual characteristics influencing the glycemic response to MO supplementation. No differences in the biomarker’s change scores were found between the groups; however, the decision tree analysis revealed that plasma TNF-α was a significant predictor of the subject’s HbA1c response (improvement YES/NO; 77% correct classification) in the MO group. In conclusion, TNF-α seems to be a key factor to identify potential respondents to MO leaf powder.This article is part of the R+D+i Project AGL2017-86044-C2-1-R, funded by MCIN/AEI/10.13039/501100011033/ and “ERDF A way of making Europe”.The authors acknowledge support of the publication fee by the CSIC Open Access Publication Support Initiative through its Unit of Information Resources for Research (URICI). The authors are grateful to all the participants for their interest in and support of scientific research.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionCSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)Consejo Superior de Investigaciones Científicas (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/268981reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-86044-C2-1-Rhttps://doi.org/10.3390/nu14091937Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2689812026-05-22T06:33:51Z
dc.title.none.fl_str_mv Effects of Moringa oleifera Lam. supplementation on inflammatory and cardiometabolic markers in subjects with prediabetes
title Effects of Moringa oleifera Lam. supplementation on inflammatory and cardiometabolic markers in subjects with prediabetes
spellingShingle Effects of Moringa oleifera Lam. supplementation on inflammatory and cardiometabolic markers in subjects with prediabetes
Díaz-Prieto, Ligia E.
Moringa oleifera Lam.
Serum lipid profile
Food supplement
Inflammatory markers
Prediabetes
Glycemic control
title_short Effects of Moringa oleifera Lam. supplementation on inflammatory and cardiometabolic markers in subjects with prediabetes
title_full Effects of Moringa oleifera Lam. supplementation on inflammatory and cardiometabolic markers in subjects with prediabetes
title_fullStr Effects of Moringa oleifera Lam. supplementation on inflammatory and cardiometabolic markers in subjects with prediabetes
title_full_unstemmed Effects of Moringa oleifera Lam. supplementation on inflammatory and cardiometabolic markers in subjects with prediabetes
title_sort Effects of Moringa oleifera Lam. supplementation on inflammatory and cardiometabolic markers in subjects with prediabetes
dc.creator.none.fl_str_mv Díaz-Prieto, Ligia E.
Gómez-Martínez, Sonia
Vicente-Castro, Iván
Heredia-Díaz, Carlos
Gónzalez Romero, Elena Aurora
Martín-Ridaura, Carmen
Ceinos, Mercedes
Picón, María J.
Marcos, Ascensión
Nova, Esther
author Díaz-Prieto, Ligia E.
author_facet Díaz-Prieto, Ligia E.
Gómez-Martínez, Sonia
Vicente-Castro, Iván
Heredia-Díaz, Carlos
Gónzalez Romero, Elena Aurora
Martín-Ridaura, Carmen
Ceinos, Mercedes
Picón, María J.
Marcos, Ascensión
Nova, Esther
author_role author
author2 Gómez-Martínez, Sonia
Vicente-Castro, Iván
Heredia-Díaz, Carlos
Gónzalez Romero, Elena Aurora
Martín-Ridaura, Carmen
Ceinos, Mercedes
Picón, María J.
Marcos, Ascensión
Nova, Esther
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)
Consejo Superior de Investigaciones Científicas (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Moringa oleifera Lam.
Serum lipid profile
Food supplement
Inflammatory markers
Prediabetes
Glycemic control
topic Moringa oleifera Lam.
Serum lipid profile
Food supplement
Inflammatory markers
Prediabetes
Glycemic control
description This article belongs to the Special Issue Obesity and Inflammation: The Role of Nutrition and Diet.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/268981
url http://hdl.handle.net/10261/268981
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-86044-C2-1-R
https://doi.org/10.3390/nu14091937
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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