Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota

Ellagitannins (ETs) and ellagic acid (EA) are dietary polyphenols poorly absorbed but extensively metabolized by the human gut microbiota to produce different urolithins (Uros). Depending on the individuals' microbial signatures, ETs metabolism can yield the Uro metabotypes A, B, or 0, potentia...

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Autores: García-Villalba, Rocío, Tomás Barberán, Francisco, Iglesias-Aguirre, Carlos E., Giménez-Bastida, J. A., González-Sarrías, Antonio, Selma, María Victoria, Espín de Gea, Juan Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/337759
Acceso en línea:http://hdl.handle.net/10261/337759
Access Level:acceso abierto
Palabra clave:Brain disposition
Ellagic acid
Gut microbiota
Neurodegenerative
Polyphenol
Urolithins
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spelling Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiotaGarcía-Villalba, RocíoTomás Barberán, FranciscoIglesias-Aguirre, Carlos E.Giménez-Bastida, J. A.González-Sarrías, AntonioSelma, María VictoriaEspín de Gea, Juan CarlosBrain dispositionEllagic acidGut microbiotaNeurodegenerativePolyphenolUrolithinsEllagitannins (ETs) and ellagic acid (EA) are dietary polyphenols poorly absorbed but extensively metabolized by the human gut microbiota to produce different urolithins (Uros). Depending on the individuals' microbial signatures, ETs metabolism can yield the Uro metabotypes A, B, or 0, potentially impacting human health after consuming ETs. Human evidence points to improved brain health after consuming ET-rich foods, mainly pomegranate juices and extracts containing punicalagin, punicalin, and different EA-derivatives. Although ETs and (or) EA are necessary to exert the effects, the precise mechanism, actual metabolites, or final drivers responsible for the observed effects have not been unraveled. The cause-and-effect evidence on Uro-A administration and the improvement of animal brain health is consistent but not addressed in humans. The Uro-A's in vivo anti-inflammatory, mitophagy, autophagy, and mitochondrial biogenesis activities suggest it as a possible final driver in neuroprotection. However, the precise Uro metabolic forms reaching the brain are unknown. In addition to the possible participation of direct effectors in brain tissues, the current evidence points out that improving blood flow, gut microbiota ecology, and gut barrier by ET-rich foods and (or) Uro-A could contribute to the neuroprotective effects. We show here the current human evidence on ETs and brain health, the possible link between the gut microbiota metabolism of ETs and their effects, including the preservation of the gut barrier integrity, and the possible role of Uros. Finally, we propose a roadmap to address what is missing on ETs, Uros, and neuroprotectionThis work was supported by the Projects PID 2019-103914RB-I00 from the Ministry of Science and Innovation (MCIN/AEI/10.13039/501100011033, Spain) and 21647/PDC/21, 20880/PI/18 and 19900/GERM/15 (Fundación Séneca de la Región de Murcia, Spain). C.E.I.-A. holds a predoctoral grant from MICIN (grant number FPU18/03961, Spain). J.A.G.-B. was supported by a Standard European Marie Curie Fellowship from the European Commission (European Union's Horizon, 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 838991).Peer reviewedElsevierMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Fundación SénecaEuropean CommissionMinisterio de Ciencia, Innovación y Universidades (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/337759reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-103914RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FPU18info:eu-repo/grantAgreement/EC/H2020/838991https://doi.org/10.1016/j.mam.2022.101109Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3377592026-05-22T06:33:51Z
dc.title.none.fl_str_mv Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota
title Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota
spellingShingle Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota
García-Villalba, Rocío
Brain disposition
Ellagic acid
Gut microbiota
Neurodegenerative
Polyphenol
Urolithins
title_short Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota
title_full Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota
title_fullStr Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota
title_full_unstemmed Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota
title_sort Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota
dc.creator.none.fl_str_mv García-Villalba, Rocío
Tomás Barberán, Francisco
Iglesias-Aguirre, Carlos E.
Giménez-Bastida, J. A.
González-Sarrías, Antonio
Selma, María Victoria
Espín de Gea, Juan Carlos
author García-Villalba, Rocío
author_facet García-Villalba, Rocío
Tomás Barberán, Francisco
Iglesias-Aguirre, Carlos E.
Giménez-Bastida, J. A.
González-Sarrías, Antonio
Selma, María Victoria
Espín de Gea, Juan Carlos
author_role author
author2 Tomás Barberán, Francisco
Iglesias-Aguirre, Carlos E.
Giménez-Bastida, J. A.
González-Sarrías, Antonio
Selma, María Victoria
Espín de Gea, Juan Carlos
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Fundación Séneca
European Commission
Ministerio de Ciencia, Innovación y Universidades (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Brain disposition
Ellagic acid
Gut microbiota
Neurodegenerative
Polyphenol
Urolithins
topic Brain disposition
Ellagic acid
Gut microbiota
Neurodegenerative
Polyphenol
Urolithins
description Ellagitannins (ETs) and ellagic acid (EA) are dietary polyphenols poorly absorbed but extensively metabolized by the human gut microbiota to produce different urolithins (Uros). Depending on the individuals' microbial signatures, ETs metabolism can yield the Uro metabotypes A, B, or 0, potentially impacting human health after consuming ETs. Human evidence points to improved brain health after consuming ET-rich foods, mainly pomegranate juices and extracts containing punicalagin, punicalin, and different EA-derivatives. Although ETs and (or) EA are necessary to exert the effects, the precise mechanism, actual metabolites, or final drivers responsible for the observed effects have not been unraveled. The cause-and-effect evidence on Uro-A administration and the improvement of animal brain health is consistent but not addressed in humans. The Uro-A's in vivo anti-inflammatory, mitophagy, autophagy, and mitochondrial biogenesis activities suggest it as a possible final driver in neuroprotection. However, the precise Uro metabolic forms reaching the brain are unknown. In addition to the possible participation of direct effectors in brain tissues, the current evidence points out that improving blood flow, gut microbiota ecology, and gut barrier by ET-rich foods and (or) Uro-A could contribute to the neuroprotective effects. We show here the current human evidence on ETs and brain health, the possible link between the gut microbiota metabolism of ETs and their effects, including the preservation of the gut barrier integrity, and the possible role of Uros. Finally, we propose a roadmap to address what is missing on ETs, Uros, and neuroprotection
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/337759
url http://hdl.handle.net/10261/337759
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-103914RB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FPU18
info:eu-repo/grantAgreement/EC/H2020/838991
https://doi.org/10.1016/j.mam.2022.101109
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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repository.mail.fl_str_mv
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