North African populations carry the signature of admixture with Neandertals

One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient populat...

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Autores: Sánchez Quinto, Federico, Rodríguez Botigué, Laura, Civit Vives, Sergi, Arenas Solà, Concepción, Ávila-Arcos, María C., Bustamante, Carlos D., Comas, David, Lalueza Fox, Carles, 1965-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/43562
Acceso en línea:https://hdl.handle.net/2445/43562
Access Level:acceso abierto
Palabra clave:ADN
Paleobiologia
Home de Neandertal
Àfrica del Nord
Paleobiologia evolutiva
DNA
Paleobiology
Neanderthals
Africa, North
Evolutionary paleobiology
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spelling North African populations carry the signature of admixture with NeandertalsSánchez Quinto, FedericoRodríguez Botigué, LauraCivit Vives, SergiArenas Solà, ConcepciónÁvila-Arcos, María C.Bustamante, Carlos D.Comas, DavidLalueza Fox, Carles, 1965-ADNPaleobiologiaHome de NeandertalÀfrica del NordPaleobiologia evolutivaDNAPaleobiologyNeanderthalsAfrica, NorthEvolutionary paleobiologyOne of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals.Public Library of Science (PLoS)2013201320122013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/43562Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0047765PLoS One, 2012, vol. 7, num. 10, p. e47765http://dx.doi.org/10.1371/journal.pone.0047765cc-by (c) Sánchez Quinto, F. et al., 2012http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/435622026-05-29T05:05:01Z
dc.title.none.fl_str_mv North African populations carry the signature of admixture with Neandertals
title North African populations carry the signature of admixture with Neandertals
spellingShingle North African populations carry the signature of admixture with Neandertals
Sánchez Quinto, Federico
ADN
Paleobiologia
Home de Neandertal
Àfrica del Nord
Paleobiologia evolutiva
DNA
Paleobiology
Neanderthals
Africa, North
Evolutionary paleobiology
title_short North African populations carry the signature of admixture with Neandertals
title_full North African populations carry the signature of admixture with Neandertals
title_fullStr North African populations carry the signature of admixture with Neandertals
title_full_unstemmed North African populations carry the signature of admixture with Neandertals
title_sort North African populations carry the signature of admixture with Neandertals
dc.creator.none.fl_str_mv Sánchez Quinto, Federico
Rodríguez Botigué, Laura
Civit Vives, Sergi
Arenas Solà, Concepción
Ávila-Arcos, María C.
Bustamante, Carlos D.
Comas, David
Lalueza Fox, Carles, 1965-
author Sánchez Quinto, Federico
author_facet Sánchez Quinto, Federico
Rodríguez Botigué, Laura
Civit Vives, Sergi
Arenas Solà, Concepción
Ávila-Arcos, María C.
Bustamante, Carlos D.
Comas, David
Lalueza Fox, Carles, 1965-
author_role author
author2 Rodríguez Botigué, Laura
Civit Vives, Sergi
Arenas Solà, Concepción
Ávila-Arcos, María C.
Bustamante, Carlos D.
Comas, David
Lalueza Fox, Carles, 1965-
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADN
Paleobiologia
Home de Neandertal
Àfrica del Nord
Paleobiologia evolutiva
DNA
Paleobiology
Neanderthals
Africa, North
Evolutionary paleobiology
topic ADN
Paleobiologia
Home de Neandertal
Àfrica del Nord
Paleobiologia evolutiva
DNA
Paleobiology
Neanderthals
Africa, North
Evolutionary paleobiology
description One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals.
publishDate 2012
dc.date.none.fl_str_mv 2012
2013
2013
2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/43562
url https://hdl.handle.net/2445/43562
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0047765
PLoS One, 2012, vol. 7, num. 10, p. e47765
http://dx.doi.org/10.1371/journal.pone.0047765
dc.rights.none.fl_str_mv cc-by (c) Sánchez Quinto, F. et al., 2012
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Sánchez Quinto, F. et al., 2012
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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