In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells.
The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential o...
| Autores: | , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Recursos: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/18791 |
| Acesso em linha: | http://hdl.handle.net/20.500.12105/18791 |
| Access Level: | acceso abierto |
| Palavra-chave: | avian embryo cardiac regeneration cartilage chondrocytes differentiation epicardial-derived cells epicardium proepicardium quail to chick chimeras Cell Differentiation Chondrocytes Embryonic Stem Cells Neural Crest Pericardium |
| Resumo: | The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential of epicardial lineage cells suggest they could also differentiate into chondrocytes. In this work, we describe the formation of cardiac cartilage clusters from proepicardial cells, both in vivo and in vitro. Our findings report, for the first time, cartilage formation from epicardial progenitor cells, and strongly support the concept of proepicardial cells as multipotent connective progenitors. These results are relevant to our understanding of cardiac cell complexity and the responses of cardiac connective tissues to pathologic stimuli. |
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