Association between gestational weight gain, gestational diabetes risk, and obstetric outcomes

Excess gestational weight gain (GWG) is associated with the development of gestational diabetes mellitus (GDM). Lifestyle trials have not achieved much GWG limitation, and have largely failed to prevent GDM. We compared the effect of substantial GWG limitation on maternal GDM risk. Pregnant women wi...

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Detalhes bibliográficos
Autores: Simmons, David|||0000-0003-0560-0761, Devlieger, Roland|||0000-0001-7837-4684, van Assche, Andre, Galjaard, Sander|||0000-0002-4254-6664, Corcoy i Pla, Rosa|||0000-0001-5055-6814, Adelantado, Juan M.|||0000-0001-6399-4856, Dunne, Fidelma|||0000-0003-3682-9403, Desoye, Gernot|||0000-0002-5715-3230, Kautzky-Willer, Alexandra|||0000-0002-3520-4105, Damm, Peter|||0000-0002-2067-5246, Mathiesen, Elisabeth Reinhardt|||0000-0003-3279-0863, Jensen, Dorte M.|||0000-0002-3298-9824, Andersen, Lise-Lotte|||0000-0003-2997-2228, Lapolla, Annunziata, Dalfra, Maria Grazia|||0000-0002-3011-0521, Bertolotto, Alessandra|||0000-0003-1578-5421, Wender-Ozegowska, Ewa|||0000-0002-5492-8651, Zawiejska, Agnieszka|||0000-0002-3616-6550, Hill, David, Snoek, Frank J., Van Poppel, Mireille|||0000-0001-5694-4324
Formato: artículo
Fecha de publicación:2018
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:286861
Acesso em linha:https://ddd.uab.cat/record/286861
https://dx.doi.org/urn:doi:10.3390/nu10111568
Access Level:acceso abierto
Palavra-chave:Gestational diabetes mellitus
Healthy eating
Lifestyle intervention
Motivational interviewing
Overweight
Physical activity
Pregnancy
Prevention
Randomised controlled trial
Descrição
Resumo:Excess gestational weight gain (GWG) is associated with the development of gestational diabetes mellitus (GDM). Lifestyle trials have not achieved much GWG limitation, and have largely failed to prevent GDM. We compared the effect of substantial GWG limitation on maternal GDM risk. Pregnant women with a body mass index (BMI) ≥29 kg/m <20 weeks gestation without GDM (n = 436) were randomized, in a multicenter trial, to usual care (UC), healthy eating (HE), physical activity (PA), or HE and PA lifestyle interventions. GWG over the median was associated with higher homeostasis model assessment insulin resistance (HOMA-IR) and insulin secretion (Stumvoll phases 1 and 2), a higher fasting plasma glucose (FPG) at 24-28 weeks (4.66 ± 0.43 vs. 4.61 ± 0.40 mmol/L, p < 0.01), and a higher rate of caesarean section (38% vs. 27% p < 0.05). The GWG over the median at 35-37 weeks was associated with a higher rate of macrosomia (25% vs. 16%, p < 0.05). A post hoc comparison among women from the five sites with a GWG difference.

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