Interleukin (IL)-1 beta, IL-6 and tumor necrosis factor in patients with seasonal flu
Introduction. The role of tumor necrosis factor (TNF), interleukin (IL)-1 beta and IL-6 in the pathogenicity of seasonal flu is unknown. Methods. We analyzed the profiles of these cytokines in 77 flu patients and 17 controls with non-flu respiratory infection, using molecular biology techniques (rea...
| Autores: | , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | España |
| Recursos: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p2825 |
| Acesso em linha: | https://fisabio.portalinvestigacion.com/publicaciones/2825 |
| Access Level: | acceso abierto |
| Palavra-chave: | Respiratory Tract Infections Influenza Human Pneumonia |
| Resumo: | Introduction. The role of tumor necrosis factor (TNF), interleukin (IL)-1 beta and IL-6 in the pathogenicity of seasonal flu is unknown. Methods. We analyzed the profiles of these cytokines in 77 flu patients and 17 controls with non-flu respiratory infection, using molecular biology techniques (real-time polymerase chain reaction). Results. Flu patients had lower monocyte counts (p=0.029) and a slightly lower median level of IL-6 (P=0.05) than the control group. Twenty-four flu patients (31.2%) had pneumonia; this group had higher C-reactive proteins (p=0.01) and monocyte levels (p=0.009). Pro-inflammatory cytokines levels did not rise in patients with pneumonia complicating seasonal influenza Conclusion. IL-6 levels were lower in adults with influenza. |
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