The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration
Outcomes research; Risk factors
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/7847 |
| Acceso en línea: | https://hdl.handle.net/11351/7847 http://hdl.handle.net/11351/7847 |
| Access Level: | acceso abierto |
| Palabra clave: | Vàlvula aòrtica - Cirurgia Immunoglobulines DISEASES::Cardiovascular Diseases::Heart Diseases Other subheadings::Other subheadings::Other subheadings::/surgery ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas Otros calificadores::Otros calificadores::Otros calificadores::/cirugía |
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The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration |
| title |
The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration |
| spellingShingle |
The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration Senage, Thomas Vàlvula aòrtica - Cirurgia Immunoglobulines DISEASES::Cardiovascular Diseases::Heart Diseases Other subheadings::Other subheadings::Other subheadings::/surgery ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas Otros calificadores::Otros calificadores::Otros calificadores::/cirugía |
| title_short |
The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration |
| title_full |
The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration |
| title_fullStr |
The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration |
| title_full_unstemmed |
The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration |
| title_sort |
The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration |
| dc.creator.none.fl_str_mv |
Senage, Thomas Paul, Anu Le Tourneau, Thierry Fellah-Hebia, Imen Vadori, Marta Bashir, Salam Evangelista Masip, Artur Casós Vásquez, Kelly Blasco Lucas, Arnau Permanyer Buada, Eduard Galiñanes Hernández, Manuel |
| author |
Senage, Thomas |
| author_facet |
Senage, Thomas Paul, Anu Le Tourneau, Thierry Fellah-Hebia, Imen Vadori, Marta Bashir, Salam Evangelista Masip, Artur Casós Vásquez, Kelly Blasco Lucas, Arnau Permanyer Buada, Eduard Galiñanes Hernández, Manuel |
| author_role |
author |
| author2 |
Paul, Anu Le Tourneau, Thierry Fellah-Hebia, Imen Vadori, Marta Bashir, Salam Evangelista Masip, Artur Casós Vásquez, Kelly Blasco Lucas, Arnau Permanyer Buada, Eduard Galiñanes Hernández, Manuel |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Senage T] Institut du Thorax, Institut National de la Santé et de la Recherche Médicale UMR1087, University Hospital, Nantes, France. Institut National de la Santé et de la Recherche Médicale UMR 1246-SPHERE, Nantes University, Tours University, Nantes, France. [Paul A] Department of Cell Research and Immunology, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. [Le Tourneau T, Fellah-Hebia I] Institut du Thorax, Institut National de la Santé et de la Recherche Médicale UMR1087, University Hospital, Nantes, France. [Vadori M] Consortium for Research in Organ Transplantation, Ospedale Giustinianeo, Padova, Italy. [Bashir S] Department of Cell Research and Immunology, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. [Galiñanes M] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Evangelista A] Servei de Cardiologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Casós K] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Infectious Diseases and Transplantation Division, Institut d’Investigació Biomèdica de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain. Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Blasco-Lucas A] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Cardiac Surgery Department, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain. [Permanyer E] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Department of Cardiac Surgery, Quironsalud Teknon Heart Institute, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Vàlvula aòrtica - Cirurgia Immunoglobulines DISEASES::Cardiovascular Diseases::Heart Diseases Other subheadings::Other subheadings::Other subheadings::/surgery ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas Otros calificadores::Otros calificadores::Otros calificadores::/cirugía |
| topic |
Vàlvula aòrtica - Cirurgia Immunoglobulines DISEASES::Cardiovascular Diseases::Heart Diseases Other subheadings::Other subheadings::Other subheadings::/surgery ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas Otros calificadores::Otros calificadores::Otros calificadores::/cirugía |
| description |
Outcomes research; Risk factors |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022 2022 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/11351/7847 http://hdl.handle.net/11351/7847 |
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https://hdl.handle.net/11351/7847 http://hdl.handle.net/11351/7847 |
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Inglés |
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Inglés |
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Nature Medicine;28 https://doi.org/10.1038/s41591-022-01682-w info:eu-repo/grantAgreement/EC/FP7/603049 info:eu-repo/grantAgreement/ES/PERIS2016-2020/SLT002%2F16%2F00445 |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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Nature Research |
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Nature Research |
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Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869409984778862592 |
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The role of antibody responses against glycans in bioprosthetic heart valve calcification and deteriorationSenage, ThomasPaul, AnuLe Tourneau, ThierryFellah-Hebia, ImenVadori, MartaBashir, SalamEvangelista Masip, ArturCasós Vásquez, KellyBlasco Lucas, ArnauPermanyer Buada, EduardGaliñanes Hernández, ManuelVàlvula aòrtica - CirurgiaImmunoglobulinesDISEASES::Cardiovascular Diseases::Heart DiseasesOther subheadings::Other subheadings::Other subheadings::/surgeryENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacasOtros calificadores::Otros calificadores::Otros calificadores::/cirugíaOutcomes research; Risk factorsInvestigación de resultados; Factores de riesgoRecerca dels resultats; Factors de riscBioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart valves but their susceptibility to structural valve degeneration (SVD) limits their use in young patients. We hypothesized that antibodies against immunogenic glycans present on BHVs, particularly antibodies against the xenoantigens galactose-α1,3-galactose (αGal) and N-glycolylneuraminic acid (Neu5Gc), could mediate their deterioration through calcification. We established a large longitudinal prospective international cohort of patients (n = 1668, 34 ± 43 months of follow-up (0.1–182); 4,998 blood samples) to investigate the hemodynamics and immune responses associated with BHVs up to 15 years after aortic valve replacement. Early signs of SVD appeared in <5% of BHV recipients within 2 years. The levels of both anti-αGal and anti-Neu5Gc IgGs significantly increased one month after BHV implantation. The levels of these IgGs declined thereafter but anti-αGal IgG levels declined significantly faster in control patients compared to BHV recipients. Neu5Gc, anti-Neu5Gc IgG and complement deposition were found in calcified BHVs at much higher levels than in calcified native aortic valves. Moreover, in mice, anti-Neu5Gc antibodies were unable to promote calcium deposition on subcutaneously implanted BHV tissue engineered to lack αGal and Neu5Gc antigens. These results indicate that BHVs manufactured using donor tissues deficient in αGal and Neu5Gc could be less prone to immune-mediated deterioration and have improved durability.This work was supported by the European Union Seventh Framework Program (FP7/2007/2013) under grant agreement no. 603049 for the Translink Consortium. This research was also funded by a European Union H2020 Program grant no. ERC-2016-STG-716220 to V.P-K. and by the Elizabeth and Nicholas Slezak Super Center for Cardiac Research and Medical Engineering (to V.P-K.). This work was supported by an Institut National de la Santé et de la Recherche Médicale translational grant no. 2012-2016 to T.L.T. This work was supported by the Ministerio de Economía y Competitividad-ISCiii (PI15/00181) and the PERIS SLT002/16/00445 funded by the Department of Health of Generalitat de Catalunya (both granted to C.C.), and cofunded by FEDER (European Regional Development Fund), a way to build Europe. This work was supported by an Israel Ministry of Science & Technology PhD fellowship to S.B. We thank L. Adler for her assistance in the affinity purification of anti-Neu5Gc antibodies and IgG subclass analysis. Finally, we thank N. Bovin from the Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, who provided the Bdi-C3 PAA substrate needed to develop the anti-αGal assays.Nature ResearchInstitut Català de la Salut[Senage T] Institut du Thorax, Institut National de la Santé et de la Recherche Médicale UMR1087, University Hospital, Nantes, France. Institut National de la Santé et de la Recherche Médicale UMR 1246-SPHERE, Nantes University, Tours University, Nantes, France. [Paul A] Department of Cell Research and Immunology, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. [Le Tourneau T, Fellah-Hebia I] Institut du Thorax, Institut National de la Santé et de la Recherche Médicale UMR1087, University Hospital, Nantes, France. [Vadori M] Consortium for Research in Organ Transplantation, Ospedale Giustinianeo, Padova, Italy. [Bashir S] Department of Cell Research and Immunology, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. [Galiñanes M] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Evangelista A] Servei de Cardiologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Casós K] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Infectious Diseases and Transplantation Division, Institut d’Investigació Biomèdica de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain. Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Blasco-Lucas A] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Cardiac Surgery Department, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain. [Permanyer E] Servei de Cirurgia Cardíaca, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Department of Cardiac Surgery, Quironsalud Teknon Heart Institute, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7847http://hdl.handle.net/11351/7847Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNature Medicine;28https://doi.org/10.1038/s41591-022-01682-winfo:eu-repo/grantAgreement/EC/FP7/603049info:eu-repo/grantAgreement/ES/PERIS2016-2020/SLT002%2F16%2F00445Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/78472026-05-29T05:05:01Z |
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15.81155 |