Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies

Background: The pandemic of cardiovascular disease (CVD) and type 2 diabetes (T2D) requires the identifcation of new predictor biomarkers. Biomarkers potentially modifable with lifestyle changes deserve a special interest. Our aims were to analyze: (a) The associations of lysine, 2-aminoadipic acid...

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Autores: Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06, Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9, Clish, C.B. (Clary B.)|||/items/91a609cf-9023-48b1-a2cd-83cc210ebed4, Li, J. (Jun)|||/items/4d55731f-bea5-4170-9b0e-1b7d943f4c75, Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0, Dennis, C. (Courtney)|||/items/3f88f258-0481-4087-a9bf-1aafa43326ef, Liang, L. (Liming)|||/items/ed4ee918-f3fc-4e03-bacf-8caba63580be, Salas-Huetos, A. (Albert)|||/items/f6375d33-94e9-4ca9-93be-6010e7adb674, Pierce, K.A. (Kerry A.)|||/items/00383d79-0a72-40ef-ba7f-2640c611d7f9, Guasch-Ferre, M. (Marta)|||/items/55c7d61d-930e-4894-92e6-429f5d71f807, Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41, Ros, E. (Emilio)|||/items/8c9fcd5a-f4ca-4a48-8fad-4737d7d5ca7f, Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265, Gomez-Gracia, E. (Enrique)|||/items/89359409-0217-44dd-94b0-14f45dba2c99, Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b, Lapetra, J. (José)|||/items/c14c3d23-c16a-4a2c-9a96-e1088196339d, Romaguera, D. (Dora)|||/items/54bd463f-ee9f-4c7a-b33e-78633766680a, Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d, Serra-Majem, L. (Luis)|||/items/2b0e8280-1783-4e01-8f35-cc7161c52ff7, Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6, Hu, F.B. (Frank B.)|||/items/038ab309-7025-4457-a78e-835b9a1d8415, Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/63155
Acceso en línea:https://hdl.handle.net/10171/63155
Access Level:acceso abierto
Palabra clave:Biomarkers
Metabolites
Cardiovascular disease
Type 2 diabetes
Dietary intervention
Descripción
Sumario:Background: The pandemic of cardiovascular disease (CVD) and type 2 diabetes (T2D) requires the identifcation of new predictor biomarkers. Biomarkers potentially modifable with lifestyle changes deserve a special interest. Our aims were to analyze: (a) The associations of lysine, 2-aminoadipic acid (2-AAA) or pipecolic acid with the risk of T2D or CVD in the PREDIMED trial; (b) the efect of the dietary intervention on 1-year changes in these metabolites, and (c) whether the Mediterranean diet (MedDiet) interventions can modify the efects of these metabolites on CVD or T2D risk. Methods: Two unstratifed case-cohort studies nested within the PREDIMED trial were used. For CVD analyses, we selected 696 non-cases and 221 incident CVD cases; for T2D, we included 610 non-cases and 243 type 2 diabetes incident cases. Metabolites were quantifed using liquid chromatography–tandem mass spectrometry, at baseline and after 1-year of intervention. Results: In weighted Cox regression models, we found that baseline lysine (HR+1 SD increase=1.26; 95% CI 1.06–1.51) and 2-AAA (HR+1 SD increase=1.28; 95% CI 1.05–1.55) were both associated with a higher risk of T2D, but not with CVD. A signifcant interaction (p=0.032) between baseline lysine and T2D on the risk of CVD was observed: subjects with prevalent T2D and high levels of lysine exhibited the highest risk of CVD. The intervention with MedDiet did not have a signifcant efect on 1-year changes of the metabolites. Conclusions: Our results provide an independent prospective replication of the association of 2-AAA with future risk of T2D. We show an association of lysine with subsequent CVD risk, which is apparently diabetes-dependent. No evidence of efects of MedDiet intervention on lysine, 2-AAA or pipecolic acid changes was found.

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