Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives

Antimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environ...

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Autores: Perestrelo, Sara, Amaro, Ana, Brouwer, Michael S. M., Clemente, Lurdes, Ribeiro Duarte, Ana Sofia, Kaesbohrer, Annemarie, Karpíšková, Renata, López Chavarrías, Vicente, Morris, Dearbháile, Prendergast, Deirdre, Pista, Angela, Silveira, Leonor, Skarżyńska, Magdalena, Slowey, Rosemarie, Veldman, Kees T., Zając, Magdalena, Burgess, Catherine, Álvarez Sánchez, Julio
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/107541
Acceso en línea:https://hdl.handle.net/20.500.14352/107541
Access Level:acceso abierto
Palabra clave:636.09
Escherichia coli
extended-spectrum beta-lactamase (ESBL)
AmpC beta-lactamase (AmpC)
One Health
monitoring
Veterinaria
3109 Ciencias Veterinarias
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repository_id_str
spelling Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and PerspectivesPerestrelo, SaraAmaro, AnaBrouwer, Michael S. M.Clemente, LurdesRibeiro Duarte, Ana SofiaKaesbohrer, AnnemarieKarpíšková, RenataLópez Chavarrías, VicenteMorris, DearbháilePrendergast, DeirdrePista, AngelaSilveira, LeonorSkarżyńska, MagdalenaSlowey, RosemarieVeldman, Kees T.Zając, MagdalenaBurgess, CatherineÁlvarez Sánchez, Julio636.09Escherichia coliextended-spectrum beta-lactamase (ESBL)AmpC beta-lactamase (AmpC)One HealthmonitoringVeterinaria3109 Ciencias VeterinariasAntimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environmental sources and its resistant phenotype, derived from the carriage of plasmid-borne extended-spectrum and AmpC β-lactamases, which limits the choice of effective antimicrobial therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible sources involved in its transmission, and its study would require databases ideally comprising information from animal (livestock, companion, wildlife), human, and environmental sources. Here, we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here.MDPIUniversidad Complutense de Madrid20232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/107541reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1075412026-06-02T12:44:21Z
dc.title.none.fl_str_mv Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives
title Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives
spellingShingle Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives
Perestrelo, Sara
636.09
Escherichia coli
extended-spectrum beta-lactamase (ESBL)
AmpC beta-lactamase (AmpC)
One Health
monitoring
Veterinaria
3109 Ciencias Veterinarias
title_short Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives
title_full Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives
title_fullStr Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives
title_full_unstemmed Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives
title_sort Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives
dc.creator.none.fl_str_mv Perestrelo, Sara
Amaro, Ana
Brouwer, Michael S. M.
Clemente, Lurdes
Ribeiro Duarte, Ana Sofia
Kaesbohrer, Annemarie
Karpíšková, Renata
López Chavarrías, Vicente
Morris, Dearbháile
Prendergast, Deirdre
Pista, Angela
Silveira, Leonor
Skarżyńska, Magdalena
Slowey, Rosemarie
Veldman, Kees T.
Zając, Magdalena
Burgess, Catherine
Álvarez Sánchez, Julio
author Perestrelo, Sara
author_facet Perestrelo, Sara
Amaro, Ana
Brouwer, Michael S. M.
Clemente, Lurdes
Ribeiro Duarte, Ana Sofia
Kaesbohrer, Annemarie
Karpíšková, Renata
López Chavarrías, Vicente
Morris, Dearbháile
Prendergast, Deirdre
Pista, Angela
Silveira, Leonor
Skarżyńska, Magdalena
Slowey, Rosemarie
Veldman, Kees T.
Zając, Magdalena
Burgess, Catherine
Álvarez Sánchez, Julio
author_role author
author2 Amaro, Ana
Brouwer, Michael S. M.
Clemente, Lurdes
Ribeiro Duarte, Ana Sofia
Kaesbohrer, Annemarie
Karpíšková, Renata
López Chavarrías, Vicente
Morris, Dearbháile
Prendergast, Deirdre
Pista, Angela
Silveira, Leonor
Skarżyńska, Magdalena
Slowey, Rosemarie
Veldman, Kees T.
Zając, Magdalena
Burgess, Catherine
Álvarez Sánchez, Julio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 636.09
Escherichia coli
extended-spectrum beta-lactamase (ESBL)
AmpC beta-lactamase (AmpC)
One Health
monitoring
Veterinaria
3109 Ciencias Veterinarias
topic 636.09
Escherichia coli
extended-spectrum beta-lactamase (ESBL)
AmpC beta-lactamase (AmpC)
One Health
monitoring
Veterinaria
3109 Ciencias Veterinarias
description Antimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environmental sources and its resistant phenotype, derived from the carriage of plasmid-borne extended-spectrum and AmpC β-lactamases, which limits the choice of effective antimicrobial therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible sources involved in its transmission, and its study would require databases ideally comprising information from animal (livestock, companion, wildlife), human, and environmental sources. Here, we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/107541
url https://hdl.handle.net/20.500.14352/107541
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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