IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study

Producción Científica

Detalles Bibliográficos
Autores: Jiménez Sousa, María Ángeles, Medrano, Luz María, Liu, Pilar, Fernández Rodríguez, Amanda, Almansa Mora, Raquel, Gómez Sánchez, Esther, Ortega, Alicia, Heredia Rodríguez, María, Gómez Pesquera, Estefanía, Tamayo Gómez, Eduardo, Resino, Salvador
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/45488
Acceso en línea:https://doi.org/10.1186/s13613-017-0247-8
http://uvadoc.uva.es/handle/10324/45488
Access Level:acceso abierto
Palabra clave:Interleukin-6
Interleucina-6
Single nucleotide polymorphism
Polimorfismo de nucleótido único
Septic shock
Choque séptico
Major surgery
Cirugía mayor
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spelling IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective studyJiménez Sousa, María ÁngelesMedrano, Luz MaríaLiu, PilarFernández Rodríguez, AmandaAlmansa Mora, RaquelGómez Sánchez, EstherOrtega, AliciaHeredia Rodríguez, MaríaGómez Pesquera, EstefaníaTamayo Gómez, EduardoResino, SalvadorInterleukin-6Interleucina-6Single nucleotide polymorphismPolimorfismo de nucleótido únicoSeptic shockChoque sépticoMajor surgeryCirugía mayorProducción CientíficaBackground: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, being the primary cause of death from infection, especially if not recognized and treated promptly. The aim of this study was to analyze whether IL-6 rs1800795 polymorphism is associated with septic shock-related death in European white patients who underwent major surgery. Methods: We performed a retrospective study on 202 septic shock patients who underwent major cardiac or abdominal surgery. The septic shock was established according to the international septic shock definition. The primary outcome variable was the death within 90 days after diagnosis of septic shock. The IL-6 rs1800795 polymorphism was genotyped by Sequenom’s MassARRAY platform. Results: The median age of the patients was 73 years, 63.4% were male, and more than 40% of patients had heart disease and hypertension. Overall, the survival analysis showed that 111 (55%) patients died with a survival median of 39 days (95% CI 30.7; 47.2). The genetic analysis association with survival was performed under a recessive genetic model (CC vs. GG/CG). Patients with IL-6 rs1800795 CC genotype had higher mortality rate than the IL-6 rs1800795 GG/CG genotype at days 7 [31.6% (6/19) vs. 10.4% (19/183); log-rank test (p = 0.005)] and 28 [57.9% (11/19) vs. 33.3% (61/183); log-rank test (p = 0.009)], and 90 [68.4% (13/19) vs. 53.5% (98/183); log-rank test (p = 0.006)]. The IL-6 rs1800795 CC genotype was associated with higher risk of septic shock-related death during the first 7 days [adjusted hazard ratio (aHR 4.65; p = 0.002), 28 days (aHR 2.50; p = 0.006), and 90 days (aHR 2.28; p = 0.006)] with septic shock. When patients were stratified by type of surgery, those with IL-6 rs1800795 CC genotype who underwent cardiac surgery had higher risk of death during the first 7 days (aHR 18.39; p = 0.001) and 28 days (aHR 6.1; p = 0.025) than IL-6 rs1800795 GG/GC carrier, whereas patients with IL-6 rs1800795 CC genotype who underwent abdominal surgery had higher risk of death during all follow-up (aHR 1.98; p = 0.050) than IL-6 rs1800795 GG/GC carrier. Conclusions: The presence of IL-6 rs1800795 CC genotype was associated with higher risk of septic shock-related death in patients who underwent major cardiac or abdominal surgery. These findings need robust validation in bigger independent cohorts.Instituto de Salud Carlos III (grants PI15/01451, CD13/00013, CD14/00002, and CP14CIII/00010)Junta de Castilla y Leon (grants 463/A/10 and 773/A/13)PFIZER (grant CT25-ESP01-01)Springer2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1186/s13613-017-0247-8http://uvadoc.uva.es/handle/10324/45488reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-017-0247-8info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/454882026-06-13T12:44:47Z
dc.title.none.fl_str_mv IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study
title IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study
spellingShingle IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study
Jiménez Sousa, María Ángeles
Interleukin-6
Interleucina-6
Single nucleotide polymorphism
Polimorfismo de nucleótido único
Septic shock
Choque séptico
Major surgery
Cirugía mayor
title_short IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study
title_full IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study
title_fullStr IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study
title_full_unstemmed IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study
title_sort IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study
dc.creator.none.fl_str_mv Jiménez Sousa, María Ángeles
Medrano, Luz María
Liu, Pilar
Fernández Rodríguez, Amanda
Almansa Mora, Raquel
Gómez Sánchez, Esther
Ortega, Alicia
Heredia Rodríguez, María
Gómez Pesquera, Estefanía
Tamayo Gómez, Eduardo
Resino, Salvador
author Jiménez Sousa, María Ángeles
author_facet Jiménez Sousa, María Ángeles
Medrano, Luz María
Liu, Pilar
Fernández Rodríguez, Amanda
Almansa Mora, Raquel
Gómez Sánchez, Esther
Ortega, Alicia
Heredia Rodríguez, María
Gómez Pesquera, Estefanía
Tamayo Gómez, Eduardo
Resino, Salvador
author_role author
author2 Medrano, Luz María
Liu, Pilar
Fernández Rodríguez, Amanda
Almansa Mora, Raquel
Gómez Sánchez, Esther
Ortega, Alicia
Heredia Rodríguez, María
Gómez Pesquera, Estefanía
Tamayo Gómez, Eduardo
Resino, Salvador
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Interleukin-6
Interleucina-6
Single nucleotide polymorphism
Polimorfismo de nucleótido único
Septic shock
Choque séptico
Major surgery
Cirugía mayor
topic Interleukin-6
Interleucina-6
Single nucleotide polymorphism
Polimorfismo de nucleótido único
Septic shock
Choque séptico
Major surgery
Cirugía mayor
description Producción Científica
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1186/s13613-017-0247-8
http://uvadoc.uva.es/handle/10324/45488
url https://doi.org/10.1186/s13613-017-0247-8
http://uvadoc.uva.es/handle/10324/45488
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-017-0247-8
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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