The MINDVIEW project: First results

[EN] We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, he...

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Detalles Bibliográficos
Autores: Benlloch Baviera, Jose María|||0000-0001-6073-1436, González Martínez, Antonio Javier, Pani, R., Preziosi, Enrico, Jackson, C., Murphy, J., Barbera Ballester, Julio, Correcher Salvador, Carlos, Aussenhofer, Sebastian, Gareis, D., Visvikis, Dimitris, Bert, J., Langstrom, B., Farde, Lars, Toth, M., Haggkvist, J., Caixeta, F., Kullander, K., Somlai-Schweiger, I., Schwaiger, Markus
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/146494
Acceso en línea:https://riunet.upv.es/handle/10251/146494
Access Level:acceso abierto
Palabra clave:Schizophrenia
Positron Emission Tomography
Silicon photomultipliers and magnetic resonance
Descripción
Sumario:[EN] We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from C-11-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that C-11-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naive, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia. (c) 2018 Elsevier Masson SAS. All rights reserved.

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