Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty

(1) Background: to retrospectively evaluate safety and efficacy of combined microwave ablation (MWA) and bilateral expandable titanium SpineJack (SJ) implants followed by vertebroplasty (VP) for the treatment of painful thoracolumbar pathological vertebral compression fracture. (2) Methods: from Jul...

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Autores: Pusceddu, Claudio, Marsico, Salvatore, Derudas, Daniele, Ballicu, Nicola, Melis, Luca, Zedda, Stefano, De Felice, Carlo, Calabrese, Alessandro, De Francesco, Davide, Venturini, Massimo, Santucci, Domiziana, Faiella, Eliodoro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/60197
Acceso en línea:http://hdl.handle.net/10230/60197
http://dx.doi.org/10.3390/jcm12134178
Access Level:acceso abierto
Palabra clave:Expandable titanium SpineJack implants
Interventional radiology
Microwave ablation
Percutaneous therapies
Spine metastases
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spelling Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplastyPusceddu, ClaudioMarsico, SalvatoreDerudas, DanieleBallicu, NicolaMelis, LucaZedda, StefanoDe Felice, CarloCalabrese, AlessandroDe Francesco, DavideVenturini, MassimoSantucci, DomizianaFaiella, EliodoroExpandable titanium SpineJack implantsInterventional radiologyMicrowave ablationPercutaneous therapiesSpine metastases(1) Background: to retrospectively evaluate safety and efficacy of combined microwave ablation (MWA) and bilateral expandable titanium SpineJack (SJ) implants followed by vertebroplasty (VP) for the treatment of painful thoracolumbar pathological vertebral compression fracture. (2) Methods: from July 2017 to October 2022, twenty-eight patients (13 women and 15 men; mean age 68 ± 11 years) with a history of primary neoplasm and thirty-six painful vertebral metastases with vertebral compression fracture underwent combined MWA and bilateral expandable titanium SpineJack implants with vertebroplasty. We analyzed safety through complications rate, and efficacy through vertebral height restoration and pain decrease, evaluated using a visual analogue scale (VAS), and Functional Mobility Scale (FMS), and local tumor control. Contrast-enhanced CT scans were performed at 1, 3, and 6 months and a contrast-enhanced spine MRI at 6 months after the procedure. (3) Results: Technical success rate was 100%. No procedure-related major complications or death occurred. Vertebral height restoration was observed in 22 levels (58%), with a mean anterior height restoration of 2.6 mm ± 0.6 and a mean middle height restoration of 4.4 mm ± 0.6 (p < 0.001). Mean VAS score of pain evaluation on the day before treatment was 6.3 ± 1.5 (range 4-9). At the 6-month evaluation, the median VAS score for pain was 0.4 ± 0.6 (range 0-2) with a mean reduction of 93.65% (6.8 ± 0.7 vs. 0.4 ± 0.6; p < 0.000) compared with baseline evaluation. Contrast-enhanced CT scans were performed at 1, 3, and 6 months and a contrast-enhanced spine MRI was performed at 6 months after the procedure, showing no local recurrence, implant displacement, or new fractures in the treated site. (4) Conclusions: combined microwave ablation and bilateral expandable titanium SpineJack implants with vertebroplasty is a safe and effective procedure for the treatment of pathological compressive vertebral fractures. The vertebral stabilization achieved early and persistent pain relief, increasing patient mobility, improving recovery of walking capacity, and providing local tumor control.MDPI202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/60197http://dx.doi.org/10.3390/jcm12134178reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJ Clin Med. 2023 Jun 21;12(13):4178© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/601972026-06-12T07:21:37Z
dc.title.none.fl_str_mv Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty
title Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty
spellingShingle Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty
Pusceddu, Claudio
Expandable titanium SpineJack implants
Interventional radiology
Microwave ablation
Percutaneous therapies
Spine metastases
title_short Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty
title_full Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty
title_fullStr Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty
title_full_unstemmed Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty
title_sort Percutaneous Vertebral Reconstruction (PVR) technique of pathological compression fractures: An innovative combined treatment of microwave ablation, bilateral expandable titanium spineJack implants followed by vertebroplasty
dc.creator.none.fl_str_mv Pusceddu, Claudio
Marsico, Salvatore
Derudas, Daniele
Ballicu, Nicola
Melis, Luca
Zedda, Stefano
De Felice, Carlo
Calabrese, Alessandro
De Francesco, Davide
Venturini, Massimo
Santucci, Domiziana
Faiella, Eliodoro
author Pusceddu, Claudio
author_facet Pusceddu, Claudio
Marsico, Salvatore
Derudas, Daniele
Ballicu, Nicola
Melis, Luca
Zedda, Stefano
De Felice, Carlo
Calabrese, Alessandro
De Francesco, Davide
Venturini, Massimo
Santucci, Domiziana
Faiella, Eliodoro
author_role author
author2 Marsico, Salvatore
Derudas, Daniele
Ballicu, Nicola
Melis, Luca
Zedda, Stefano
De Felice, Carlo
Calabrese, Alessandro
De Francesco, Davide
Venturini, Massimo
Santucci, Domiziana
Faiella, Eliodoro
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Expandable titanium SpineJack implants
Interventional radiology
Microwave ablation
Percutaneous therapies
Spine metastases
topic Expandable titanium SpineJack implants
Interventional radiology
Microwave ablation
Percutaneous therapies
Spine metastases
description (1) Background: to retrospectively evaluate safety and efficacy of combined microwave ablation (MWA) and bilateral expandable titanium SpineJack (SJ) implants followed by vertebroplasty (VP) for the treatment of painful thoracolumbar pathological vertebral compression fracture. (2) Methods: from July 2017 to October 2022, twenty-eight patients (13 women and 15 men; mean age 68 ± 11 years) with a history of primary neoplasm and thirty-six painful vertebral metastases with vertebral compression fracture underwent combined MWA and bilateral expandable titanium SpineJack implants with vertebroplasty. We analyzed safety through complications rate, and efficacy through vertebral height restoration and pain decrease, evaluated using a visual analogue scale (VAS), and Functional Mobility Scale (FMS), and local tumor control. Contrast-enhanced CT scans were performed at 1, 3, and 6 months and a contrast-enhanced spine MRI at 6 months after the procedure. (3) Results: Technical success rate was 100%. No procedure-related major complications or death occurred. Vertebral height restoration was observed in 22 levels (58%), with a mean anterior height restoration of 2.6 mm ± 0.6 and a mean middle height restoration of 4.4 mm ± 0.6 (p < 0.001). Mean VAS score of pain evaluation on the day before treatment was 6.3 ± 1.5 (range 4-9). At the 6-month evaluation, the median VAS score for pain was 0.4 ± 0.6 (range 0-2) with a mean reduction of 93.65% (6.8 ± 0.7 vs. 0.4 ± 0.6; p < 0.000) compared with baseline evaluation. Contrast-enhanced CT scans were performed at 1, 3, and 6 months and a contrast-enhanced spine MRI was performed at 6 months after the procedure, showing no local recurrence, implant displacement, or new fractures in the treated site. (4) Conclusions: combined microwave ablation and bilateral expandable titanium SpineJack implants with vertebroplasty is a safe and effective procedure for the treatment of pathological compressive vertebral fractures. The vertebral stabilization achieved early and persistent pain relief, increasing patient mobility, improving recovery of walking capacity, and providing local tumor control.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/60197
http://dx.doi.org/10.3390/jcm12134178
url http://hdl.handle.net/10230/60197
http://dx.doi.org/10.3390/jcm12134178
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv J Clin Med. 2023 Jun 21;12(13):4178
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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