Emerging Roles of Lysyl Oxidases in the Cardiovascular System

Lysyl oxidases (LOX and LOX-likes (LOXLs) isoenzymes) belong to a family of copper-dependent enzymes classically involved in the covalent cross-linking of collagen and elastin, a pivotal process that ensures extracellular matrix (ECM) stability and provides the tensile and elastic characteristics of...

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Autores: Martínez-González, José|||0000-0002-3894-7166, Varona, Saray|||0000-0002-7375-313X, Cañes Esteve, Laia|||0000-0002-9579-1321, Galán, María|||0000-0002-4758-8388, Briones, Ana|||0000-0001-8218-5579, Cachofeiro, Victoria, Rodríguez, Cristina|||0000-0002-6472-5647
Formato: artículo
Fecha de publicación:2019
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253360
Acesso em linha:https://ddd.uab.cat/record/253360
https://dx.doi.org/urn:doi:10.3390/biom9100610
Access Level:acceso abierto
Palavra-chave:Lysyl oxidases
Cardiovascular diseases
Atherosclerosis
Aortic aneurysm
Vascular calcification
Vascular stiffness
Myocardial fibrosis
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spelling Emerging Roles of Lysyl Oxidases in the Cardiovascular SystemNew Concepts and Therapeutic ChallengesMartínez-González, José|||0000-0002-3894-7166Varona, Saray|||0000-0002-7375-313XCañes Esteve, Laia|||0000-0002-9579-1321Galán, María|||0000-0002-4758-8388Briones, Ana|||0000-0001-8218-5579Cachofeiro, VictoriaRodríguez, Cristina|||0000-0002-6472-5647Lysyl oxidasesCardiovascular diseasesAtherosclerosisAortic aneurysmVascular calcificationVascular stiffnessMyocardial fibrosisLysyl oxidases (LOX and LOX-likes (LOXLs) isoenzymes) belong to a family of copper-dependent enzymes classically involved in the covalent cross-linking of collagen and elastin, a pivotal process that ensures extracellular matrix (ECM) stability and provides the tensile and elastic characteristics of connective tissues. Besides this structural role, in the last years, novel biological properties have been attributed to these enzymes, which can critically influence cardiovascular function. LOX and LOXLs control cell proliferation, migration, adhesion, differentiation, oxidative stress, and transcriptional regulation and, thereby, their dysregulation has been linked to a myriad of cardiovascular pathologies. Lysyl oxidase could modulate virtually all stages of the atherosclerotic process, from endothelial dysfunction and plaque progression to calcification and rupture of advanced and complicated plaques, and contributes to vascular stiffness in hypertension. The alteration of LOX/LOXLs expression underlies the development of other vascular pathologies characterized by a destructive remodeling of the ECM, such as aneurysm and artery dissections, and contributes to the adverse myocardial remodeling and dysfunction in hypertension, myocardial infarction, and obesity. This review examines the most recent advances in the study of LOX and LOXLs biology and their pathophysiological role in cardiovascular diseases with special emphasis on their potential as therapeutic targets.Universitat Autònoma de Barcelona 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/253360https://dx.doi.org/urn:doi:10.3390/biom9100610reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 RTI2018-094727-B-100Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/0919Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-00333Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CP15/00126open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2533602026-06-06T12:50:31Z
dc.title.none.fl_str_mv Emerging Roles of Lysyl Oxidases in the Cardiovascular System
New Concepts and Therapeutic Challenges
title Emerging Roles of Lysyl Oxidases in the Cardiovascular System
spellingShingle Emerging Roles of Lysyl Oxidases in the Cardiovascular System
Martínez-González, José|||0000-0002-3894-7166
Lysyl oxidases
Cardiovascular diseases
Atherosclerosis
Aortic aneurysm
Vascular calcification
Vascular stiffness
Myocardial fibrosis
title_short Emerging Roles of Lysyl Oxidases in the Cardiovascular System
title_full Emerging Roles of Lysyl Oxidases in the Cardiovascular System
title_fullStr Emerging Roles of Lysyl Oxidases in the Cardiovascular System
title_full_unstemmed Emerging Roles of Lysyl Oxidases in the Cardiovascular System
title_sort Emerging Roles of Lysyl Oxidases in the Cardiovascular System
dc.creator.none.fl_str_mv Martínez-González, José|||0000-0002-3894-7166
Varona, Saray|||0000-0002-7375-313X
Cañes Esteve, Laia|||0000-0002-9579-1321
Galán, María|||0000-0002-4758-8388
Briones, Ana|||0000-0001-8218-5579
Cachofeiro, Victoria
Rodríguez, Cristina|||0000-0002-6472-5647
author Martínez-González, José|||0000-0002-3894-7166
author_facet Martínez-González, José|||0000-0002-3894-7166
Varona, Saray|||0000-0002-7375-313X
Cañes Esteve, Laia|||0000-0002-9579-1321
Galán, María|||0000-0002-4758-8388
Briones, Ana|||0000-0001-8218-5579
Cachofeiro, Victoria
Rodríguez, Cristina|||0000-0002-6472-5647
author_role author
author2 Varona, Saray|||0000-0002-7375-313X
Cañes Esteve, Laia|||0000-0002-9579-1321
Galán, María|||0000-0002-4758-8388
Briones, Ana|||0000-0001-8218-5579
Cachofeiro, Victoria
Rodríguez, Cristina|||0000-0002-6472-5647
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Lysyl oxidases
Cardiovascular diseases
Atherosclerosis
Aortic aneurysm
Vascular calcification
Vascular stiffness
Myocardial fibrosis
topic Lysyl oxidases
Cardiovascular diseases
Atherosclerosis
Aortic aneurysm
Vascular calcification
Vascular stiffness
Myocardial fibrosis
description Lysyl oxidases (LOX and LOX-likes (LOXLs) isoenzymes) belong to a family of copper-dependent enzymes classically involved in the covalent cross-linking of collagen and elastin, a pivotal process that ensures extracellular matrix (ECM) stability and provides the tensile and elastic characteristics of connective tissues. Besides this structural role, in the last years, novel biological properties have been attributed to these enzymes, which can critically influence cardiovascular function. LOX and LOXLs control cell proliferation, migration, adhesion, differentiation, oxidative stress, and transcriptional regulation and, thereby, their dysregulation has been linked to a myriad of cardiovascular pathologies. Lysyl oxidase could modulate virtually all stages of the atherosclerotic process, from endothelial dysfunction and plaque progression to calcification and rupture of advanced and complicated plaques, and contributes to vascular stiffness in hypertension. The alteration of LOX/LOXLs expression underlies the development of other vascular pathologies characterized by a destructive remodeling of the ECM, such as aneurysm and artery dissections, and contributes to the adverse myocardial remodeling and dysfunction in hypertension, myocardial infarction, and obesity. This review examines the most recent advances in the study of LOX and LOXLs biology and their pathophysiological role in cardiovascular diseases with special emphasis on their potential as therapeutic targets.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/253360
https://dx.doi.org/urn:doi:10.3390/biom9100610
url https://ddd.uab.cat/record/253360
https://dx.doi.org/urn:doi:10.3390/biom9100610
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RTI2018-094727-B-100
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/0919
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-00333
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CP15/00126
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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