Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins

This is an, un-copyedited, author manuscript that has been accepted for publication in the Frontiers in Bioscience

Bibliographic Details
Authors: Hortelano, Sonsoles, Zeini, Miriam, Casado, Marta, Martín-Sanz, Paloma, Boscá, Lisardo
Format: article
Publication Date:2007
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/4306
Online Access:http://hdl.handle.net/10261/4306
Access Level:Open access
Keyword:Partial Hepatectomy
Nitric Oxide
Prostaglandins
Liver Regeneration
Apoptosis
Animal models
Review
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spelling Animal models for the study of liver regeneration: role of nitric oxide and prostaglandinsHortelano, SonsolesZeini, MiriamCasado, MartaMartín-Sanz, PalomaBoscá, LisardoPartial HepatectomyNitric OxideProstaglandinsLiver RegenerationApoptosisAnimal modelsReviewThis is an, un-copyedited, author manuscript that has been accepted for publication in the Frontiers in BioscienceThe mechanisms that permit adult tissues to regenerate are the object of intense study. Liver regeneration is a research area of considerable interest both from pathological and from physiological perspectives. One of the best models of the regenerative process is the two-thirds partial hepatectomy (PH). After PH, the remnant liver starts a series of timed responses that first favor cell growth and then halts hepatocyte proliferation once liver function is fully restored. The mechanisms regulating this process are complex and involve many cellular events. Initiation of liver regeneration requires the injury-related cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6), and involves the activation of cytokine-regulated transcription factors such as NF-kappaB and STAT3. An important event that takes place in the hours immediately after PH is the induction of nitric oxide synthase 2 (NOS-2) and cyclooxygenase 2 (COX-2), and the consequent release of nitric oxide (NO) and prostaglandins (PGs). NO is involved in the vascular readaptation after PH, favoring a general permeability to growth factors throughout the organ. This review examines the mechanisms that regulate NO release during liver regeneration and the animal models used to identify these pathways.S.H. is a FIS program investigator supported by Instituto de Salud Carlos III (FIS 2002/3022). M.Z. is a Community of Madrid fellow. Work has been funded by RECAVA, the Ministerio de Educación y Ciencia (SAF2002-0083 and 2005-03022), and by Fundació La Caixa (ONO3- 180-2).Peer reviewedFrontiers in Bioscience Publications200820082007info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501162021 bytesapplication/pdfhttp://hdl.handle.net/10261/4306reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglésinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/43062026-05-22T06:33:51Z
dc.title.none.fl_str_mv Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins
title Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins
spellingShingle Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins
Hortelano, Sonsoles
Partial Hepatectomy
Nitric Oxide
Prostaglandins
Liver Regeneration
Apoptosis
Animal models
Review
title_short Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins
title_full Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins
title_fullStr Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins
title_full_unstemmed Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins
title_sort Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins
dc.creator.none.fl_str_mv Hortelano, Sonsoles
Zeini, Miriam
Casado, Marta
Martín-Sanz, Paloma
Boscá, Lisardo
author Hortelano, Sonsoles
author_facet Hortelano, Sonsoles
Zeini, Miriam
Casado, Marta
Martín-Sanz, Paloma
Boscá, Lisardo
author_role author
author2 Zeini, Miriam
Casado, Marta
Martín-Sanz, Paloma
Boscá, Lisardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Partial Hepatectomy
Nitric Oxide
Prostaglandins
Liver Regeneration
Apoptosis
Animal models
Review
topic Partial Hepatectomy
Nitric Oxide
Prostaglandins
Liver Regeneration
Apoptosis
Animal models
Review
description This is an, un-copyedited, author manuscript that has been accepted for publication in the Frontiers in Bioscience
publishDate 2007
dc.date.none.fl_str_mv 2007
2008
2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/4306
url http://hdl.handle.net/10261/4306
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 162021 bytes
application/pdf
dc.publisher.none.fl_str_mv Frontiers in Bioscience Publications
publisher.none.fl_str_mv Frontiers in Bioscience Publications
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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