HIV/HBV coinfection: temporal trends and patient characteristics, Spain, 2002 to 2018

Background: Recent and reliable estimates on the prevalence of coinfection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in Europe are lacking. Aim: Leveraged on a study designed to assess HIV/HCV coinfection prevalence, we assessed the prevalence of HIV/HBV coinfection in Spai...

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Detalles Bibliográficos
Autores: Perez-Latorre, Leire, Berenguer, Juan, Mican, Rafael, Montero, Marta, Cifuentes Luna, Carmen, Puig, Teresa, Sanz, Jose, Ferrero Beneitez, Oscar Luis, de la Fuente, Belen, Rodriguez, Carmen, Reus, Sergio, Hernandez-Quero, Jose, Gaspar, Gabriel, Perez-Martinez, Laura, Garcia, Coral, Force, Lluis, Veloso, Sergio, de Miguel, Marta, Jarrin, Inmaculada, Gonzalez-Garcia, Juan, Gesida Study Grp
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19623
Acceso en línea:https://hdl.handle.net/20.500.13003/19623
Access Level:acceso abierto
Palabra clave:Hepatitis B
HIV Infections
Europe
Spain
Coinfection
Hepatitis B virus
Humans
Cross-Sectional Studies
Prevalence
Coinfección
Estudios Transversales
Virus de la Hepatitis B
Humanos
Prevalencia
Infecciones por VIH
Europa (Continente)
España
HBV therapy
HIV/HBV coinfection
hepatitis delta virus
Descripción
Sumario:Background: Recent and reliable estimates on the prevalence of coinfection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in Europe are lacking. Aim: Leveraged on a study designed to assess HIV/HCV coinfection prevalence, we assessed the prevalence of HIV/HBV coinfection in Spain in 2018 and compared the results with five similar studies performed since 2002. Methods: This cross-sectional prevalence study was carried out in 43 centres, and patients were selected using simple random sampling. The reference population comprised 40,322 patients and the sample size were 1,690 patients. Results: The prevalence of HIV/HBV coinfection in Spain at the end of 2018 was 3.2%. The prevalence in 2002, 2009, 2015, 2016 and 2017 was 4.9%, 3.4%, 3%, 3.9% and 3%, respectively. Among the HIV/HBV-coinfected patients identified in 2018, 16.7% had cirrhosis according to transient elastography and 26.3% tested positive for antibodies against hepatitis D virus. All HIV/HBVcoinfected patients were receiving drugs with activity against HBV, and 97% of those tested for HBV DNA had an HBV DNA load < 80 IU/mL. Conclusions: The prevalence of HIV/HBV coinfection in Spain remained stable at around 3% for a decade. Our data could facilitate the design of national programmes to control HBV infection and help identify areas of patient management that need improvement.

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