Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry
Objective To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). Methods Cro...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/218909 |
| Acceso en línea: | https://hdl.handle.net/2445/218909 |
| Access Level: | acceso abierto |
| Palabra clave: | Miopaties inflamatòries idiopàtiques Autoanticossos Danys Idiopathic inflammatory myopathies Autoantibodies Damage |
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oai:recercat.cat:2445/218909 |
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España |
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| dc.title.none.fl_str_mv |
Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| title |
Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| spellingShingle |
Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry Cobo Ibáñez, Tatiana Miopaties inflamatòries idiopàtiques Autoanticossos Danys Idiopathic inflammatory myopathies Autoantibodies Damage |
| title_short |
Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| title_full |
Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| title_fullStr |
Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| title_full_unstemmed |
Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| title_sort |
Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| dc.creator.none.fl_str_mv |
Cobo Ibáñez, Tatiana Castellví, Ivan Pros, Ana Domínguez Álvaro, Marta Nuño Nuño, Laura Martínez Barrio, Julia Jovaní, Vega Romero Bueno, Fredeswinda Ruiz Lucea, Esther Tomero, Eva Trallero Araguás, Ernesto Narváez, Javier Camins Fàbregas, Jordi Ruiz Román, Alberto Loarce Martos, Jesús Holgado, Susana Flores Rodríguez, V. Miguel Sivera, Francisca Merino Argumanez, Carolina Juan Mas, Antonio Altabás González, Irene Martín López, María Belzunegui Otano, Joaquín María Carrasco Cubero, Carmen Freire González, Mercedes Rúa Figueroa, Iñigo Lozano Rivas, Nuria Suarez Cuba, Julio David Martínez-Sáez, Olga Ortega Castro, Rafaela Alcocer, Patricia Gómez Gómez, Alejandro Sánchez Pernaute, Olga Tandaipan, José Luis Carrión Barberà, Irene Plasencia Rodríguez, Chamaida Ibarguengoitia Barrena, Oihane Vidal Montal, Paola Ortiz Santamaria, Vera Garrido Puñal, Noemi Riveros, Anne Delgado Frías, Esmeralda López Gómez, Juan Miguel Barbadillo, Carmen Pego Reigosa, José María Joven, Beatriz Valero Jaimes, Jesús Alejandro Naveda, Elena Turrión Nieves, Ana Isabel Seoane Mato, Daniel Prado Galbarro, Francisco Javier Puche Larrubia, María Ángeles |
| author |
Cobo Ibáñez, Tatiana |
| author_facet |
Cobo Ibáñez, Tatiana Castellví, Ivan Pros, Ana Domínguez Álvaro, Marta Nuño Nuño, Laura Martínez Barrio, Julia Jovaní, Vega Romero Bueno, Fredeswinda Ruiz Lucea, Esther Tomero, Eva Trallero Araguás, Ernesto Narváez, Javier Camins Fàbregas, Jordi Ruiz Román, Alberto Loarce Martos, Jesús Holgado, Susana Flores Rodríguez, V. Miguel Sivera, Francisca Merino Argumanez, Carolina Juan Mas, Antonio Altabás González, Irene Martín López, María Belzunegui Otano, Joaquín María Carrasco Cubero, Carmen Freire González, Mercedes Rúa Figueroa, Iñigo Lozano Rivas, Nuria Suarez Cuba, Julio David Martínez-Sáez, Olga Ortega Castro, Rafaela Alcocer, Patricia Gómez Gómez, Alejandro Sánchez Pernaute, Olga Tandaipan, José Luis Carrión Barberà, Irene Plasencia Rodríguez, Chamaida Ibarguengoitia Barrena, Oihane Vidal Montal, Paola Ortiz Santamaria, Vera Garrido Puñal, Noemi Riveros, Anne Delgado Frías, Esmeralda López Gómez, Juan Miguel Barbadillo, Carmen Pego Reigosa, José María Joven, Beatriz Valero Jaimes, Jesús Alejandro Naveda, Elena Turrión Nieves, Ana Isabel Seoane Mato, Daniel Prado Galbarro, Francisco Javier Puche Larrubia, María Ángeles |
| author_role |
author |
| author2 |
Castellví, Ivan Pros, Ana Domínguez Álvaro, Marta Nuño Nuño, Laura Martínez Barrio, Julia Jovaní, Vega Romero Bueno, Fredeswinda Ruiz Lucea, Esther Tomero, Eva Trallero Araguás, Ernesto Narváez, Javier Camins Fàbregas, Jordi Ruiz Román, Alberto Loarce Martos, Jesús Holgado, Susana Flores Rodríguez, V. Miguel Sivera, Francisca Merino Argumanez, Carolina Juan Mas, Antonio Altabás González, Irene Martín López, María Belzunegui Otano, Joaquín María Carrasco Cubero, Carmen Freire González, Mercedes Rúa Figueroa, Iñigo Lozano Rivas, Nuria Suarez Cuba, Julio David Martínez-Sáez, Olga Ortega Castro, Rafaela Alcocer, Patricia Gómez Gómez, Alejandro Sánchez Pernaute, Olga Tandaipan, José Luis Carrión Barberà, Irene Plasencia Rodríguez, Chamaida Ibarguengoitia Barrena, Oihane Vidal Montal, Paola Ortiz Santamaria, Vera Garrido Puñal, Noemi Riveros, Anne Delgado Frías, Esmeralda López Gómez, Juan Miguel Barbadillo, Carmen Pego Reigosa, José María Joven, Beatriz Valero Jaimes, Jesús Alejandro Naveda, Elena Turrión Nieves, Ana Isabel Seoane Mato, Daniel Prado Galbarro, Francisco Javier Puche Larrubia, María Ángeles |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Miopaties inflamatòries idiopàtiques Autoanticossos Danys Idiopathic inflammatory myopathies Autoantibodies Damage |
| topic |
Miopaties inflamatòries idiopàtiques Autoanticossos Danys Idiopathic inflammatory myopathies Autoantibodies Damage |
| description |
Objective To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). Methods Cross-sectional multicenter study within the Spanish Myo-Spain registry. Cases were classified as incident (<= 12 months since diagnosis) and prevalent. The main outcomes of disease activity were the Myositis Disease Activity Assessment visual analogue scale (MYOACT), the Manual Muscle Test 8 (MMT-8), physician global activity (PhGA), and extramuscular activity. Other measures of activity, damage, and quality of life included patient global disease activity, MYOACT muscular, creatine phosphokinase, Health Assessment Questionnaire, physician and patient global damage, global damage of the Myositis Damage Index, and the 12-item Short-Form Health Survey (SF-12). We analyzed associations using a multivariate generalized linear model and a simple linear regression model. Results A total of 554 patients with different diagnostic subgroups of IIM were included (136 incident and 418 prevalent cases), with 215 ASA-positive patients (58 incident and 157 prevalent cases). All measures of disease activity were higher in the incident cases (p < 0.05), except for MYOACT muscular and creatine phosphokinase, for which no differences were recorded in ASA-positive patients. No differences were found between incident and prevalent cases for measures of damage. Values for the physical component of the SF-12 were higher in the prevalent cases (p < 0.05). The multivariate model was initially significant overall for the main activity outcomes. Positivity to ASAs was positively and negatively associated with the MYOACT index and MMT-8, respectively (p < 0.05), although no association was recorded with PhGA and extramuscular activity. Prevalent cases were negatively associated with the main outcomes of activity, except with MMT-8, for which the association was positive (p < 0.05). Conclusions The main activity outcomes validated in polymyositis and dermatomyositis could also be used in other subtypes of IIM, such as antisynthetase syndrome. Recent diagnosis is associated with greater disease activity, as assessed based on these activity outcomes. PhGA and extramuscular activity are not modified by ASA positivity, thus supporting their preferred use for assessing treatment response in IIM with ASAs. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/218909 |
| url |
https://hdl.handle.net/2445/218909 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1186/s13075-024-03471-x Arthritis Research & Therapy, 2025, vol. 27, num. 1 https://doi.org/10.1186/s13075-024-03471-x |
| dc.rights.none.fl_str_mv |
cc by-nc-nd (c) Cobo-ibáñez, Tatiana et al, 2025 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc by-nc-nd (c) Cobo-ibáñez, Tatiana et al, 2025 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Springer Science and Business Media LLC |
| publisher.none.fl_str_mv |
Springer Science and Business Media LLC |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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|
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1869409928624472064 |
| spelling |
Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registryCobo Ibáñez, TatianaCastellví, IvanPros, AnaDomínguez Álvaro, MartaNuño Nuño, LauraMartínez Barrio, JuliaJovaní, VegaRomero Bueno, FredeswindaRuiz Lucea, EstherTomero, EvaTrallero Araguás, ErnestoNarváez, JavierCamins Fàbregas, JordiRuiz Román, AlbertoLoarce Martos, JesúsHolgado, SusanaFlores Rodríguez, V. MiguelSivera, FranciscaMerino Argumanez, CarolinaJuan Mas, AntonioAltabás González, IreneMartín López, MaríaBelzunegui Otano, Joaquín MaríaCarrasco Cubero, CarmenFreire González, MercedesRúa Figueroa, IñigoLozano Rivas, NuriaSuarez Cuba, Julio DavidMartínez-Sáez, OlgaOrtega Castro, RafaelaAlcocer, PatriciaGómez Gómez, AlejandroSánchez Pernaute, OlgaTandaipan, José LuisCarrión Barberà, IrenePlasencia Rodríguez, ChamaidaIbarguengoitia Barrena, OihaneVidal Montal, PaolaOrtiz Santamaria, VeraGarrido Puñal, NoemiRiveros, AnneDelgado Frías, EsmeraldaLópez Gómez, Juan MiguelBarbadillo, CarmenPego Reigosa, José MaríaJoven, BeatrizValero Jaimes, Jesús AlejandroNaveda, ElenaTurrión Nieves, Ana IsabelSeoane Mato, DanielPrado Galbarro, Francisco JavierPuche Larrubia, María ÁngelesMiopaties inflamatòries idiopàtiquesAutoanticossosDanysIdiopathic inflammatory myopathiesAutoantibodiesDamageObjective To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). Methods Cross-sectional multicenter study within the Spanish Myo-Spain registry. Cases were classified as incident (<= 12 months since diagnosis) and prevalent. The main outcomes of disease activity were the Myositis Disease Activity Assessment visual analogue scale (MYOACT), the Manual Muscle Test 8 (MMT-8), physician global activity (PhGA), and extramuscular activity. Other measures of activity, damage, and quality of life included patient global disease activity, MYOACT muscular, creatine phosphokinase, Health Assessment Questionnaire, physician and patient global damage, global damage of the Myositis Damage Index, and the 12-item Short-Form Health Survey (SF-12). We analyzed associations using a multivariate generalized linear model and a simple linear regression model. Results A total of 554 patients with different diagnostic subgroups of IIM were included (136 incident and 418 prevalent cases), with 215 ASA-positive patients (58 incident and 157 prevalent cases). All measures of disease activity were higher in the incident cases (p < 0.05), except for MYOACT muscular and creatine phosphokinase, for which no differences were recorded in ASA-positive patients. No differences were found between incident and prevalent cases for measures of damage. Values for the physical component of the SF-12 were higher in the prevalent cases (p < 0.05). The multivariate model was initially significant overall for the main activity outcomes. Positivity to ASAs was positively and negatively associated with the MYOACT index and MMT-8, respectively (p < 0.05), although no association was recorded with PhGA and extramuscular activity. Prevalent cases were negatively associated with the main outcomes of activity, except with MMT-8, for which the association was positive (p < 0.05). Conclusions The main activity outcomes validated in polymyositis and dermatomyositis could also be used in other subtypes of IIM, such as antisynthetase syndrome. Recent diagnosis is associated with greater disease activity, as assessed based on these activity outcomes. PhGA and extramuscular activity are not modified by ASA positivity, thus supporting their preferred use for assessing treatment response in IIM with ASAs.Springer Science and Business Media LLC2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/218909Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s13075-024-03471-xArthritis Research & Therapy, 2025, vol. 27, num. 1https://doi.org/10.1186/s13075-024-03471-xcc by-nc-nd (c) Cobo-ibáñez, Tatiana et al, 2025http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2189092026-05-29T05:05:01Z |
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15,81155 |