Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor

Tremor in essential tremor (ET) is generated by pathological oscillations at 4 to 12 Hz, likely originating at cerebello-thalamo-cortical pathways. However, the way in which tremor is represented in the output of the spinal cord circuitries is largely unknown because of the difficulties in identifyi...

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Autores: Gallego, Juan Álvaro, Dideriksen, Jakob L., Holobar, Ales, Ibáñez Pereda, Jaime, Pons Rovira, José Luis, Louis, Elan D., Rocón, Eduardo, Farina, Dario
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/103658
Acceso en línea:http://hdl.handle.net/10261/103658
Access Level:acceso abierto
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spelling Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremorGallego, Juan ÁlvaroDideriksen, Jakob L.Holobar, AlesIbáñez Pereda, JaimePons Rovira, José LuisLouis, Elan D.Rocón, EduardoFarina, DarioTremor in essential tremor (ET) is generated by pathological oscillations at 4 to 12 Hz, likely originating at cerebello-thalamo-cortical pathways. However, the way in which tremor is represented in the output of the spinal cord circuitries is largely unknown because of the difficulties in identifying the behavior of individual motor units from tremulous muscles. By using novel methods for the decomposition of multichannel surface EMG, we provide a systematic analysis of the discharge properties of motor units in 9 ET patients, with concurrent recordings of EEG activity. This analysis allowed inferring the contribution of common synaptic inputs to motor neurons in ET. Motor unit short-term synchronization was significantly greater in ET patients than in healthy subjects. Further, the strong association between the degree of synchronization and the peak in coherence between motor unit spike trains at the tremor frequency indicated that the high synchronization levels were generated mainly by common synaptic inputs specifically at the tremor frequency. The coherence between EEG and motor unit spike trains demonstrated the presence of common cortical input to the motor neurons at the tremor frequency. Nonetheless, the strength of this input was uncorrelated to the net common synaptic input at the tremor frequency, suggesting a contribution of spinal afferents or secondary supraspinal pathways in projecting common input at the tremor frequency. These results provide the first systematic analysis of the neural drive to the muscle in ET and elucidate some of its characteristics that determine the pathological tremulous muscle activity.This work was funded by the EU Commission [grant number EU-FP7-2011-287739 (NeuroTREMOR)].Peer reviewedEuropean Commission2014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/103658reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/287739http://jn.physiology.org/content/early/2014/09/24/jn.00531.2014Siinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1036582026-05-22T06:33:51Z
dc.title.none.fl_str_mv Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor
title Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor
spellingShingle Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor
Gallego, Juan Álvaro
title_short Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor
title_full Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor
title_fullStr Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor
title_full_unstemmed Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor
title_sort Influence of common synaptic input to motor neurons on the neural drive to muscle in essential tremor
dc.creator.none.fl_str_mv Gallego, Juan Álvaro
Dideriksen, Jakob L.
Holobar, Ales
Ibáñez Pereda, Jaime
Pons Rovira, José Luis
Louis, Elan D.
Rocón, Eduardo
Farina, Dario
author Gallego, Juan Álvaro
author_facet Gallego, Juan Álvaro
Dideriksen, Jakob L.
Holobar, Ales
Ibáñez Pereda, Jaime
Pons Rovira, José Luis
Louis, Elan D.
Rocón, Eduardo
Farina, Dario
author_role author
author2 Dideriksen, Jakob L.
Holobar, Ales
Ibáñez Pereda, Jaime
Pons Rovira, José Luis
Louis, Elan D.
Rocón, Eduardo
Farina, Dario
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
description Tremor in essential tremor (ET) is generated by pathological oscillations at 4 to 12 Hz, likely originating at cerebello-thalamo-cortical pathways. However, the way in which tremor is represented in the output of the spinal cord circuitries is largely unknown because of the difficulties in identifying the behavior of individual motor units from tremulous muscles. By using novel methods for the decomposition of multichannel surface EMG, we provide a systematic analysis of the discharge properties of motor units in 9 ET patients, with concurrent recordings of EEG activity. This analysis allowed inferring the contribution of common synaptic inputs to motor neurons in ET. Motor unit short-term synchronization was significantly greater in ET patients than in healthy subjects. Further, the strong association between the degree of synchronization and the peak in coherence between motor unit spike trains at the tremor frequency indicated that the high synchronization levels were generated mainly by common synaptic inputs specifically at the tremor frequency. The coherence between EEG and motor unit spike trains demonstrated the presence of common cortical input to the motor neurons at the tremor frequency. Nonetheless, the strength of this input was uncorrelated to the net common synaptic input at the tremor frequency, suggesting a contribution of spinal afferents or secondary supraspinal pathways in projecting common input at the tremor frequency. These results provide the first systematic analysis of the neural drive to the muscle in ET and elucidate some of its characteristics that determine the pathological tremulous muscle activity.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/103658
url http://hdl.handle.net/10261/103658
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/287739
http://jn.physiology.org/content/early/2014/09/24/jn.00531.2014
Si
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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