Effect of Vitamin D on Graft-versus-Host Disease

The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vi...

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Detalhes bibliográficos
Autores: Rodríguez Gil, Alfonso, Carrillo-Cruz, Estrella, Marrero-Cepeda, Cristina, Rodríguez, Guillermo, Pérez Simón, José Antonio
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/139395
Acesso em linha:https://hdl.handle.net/11441/139395
https://doi.org/10.3390/biomedicines10050987
Access Level:acceso abierto
Palavra-chave:Vitamin D
Calcifediol
Calcitriol
Graft-versus-host disease
Vitamin D receptor (VDR)
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repository_id_str
spelling Effect of Vitamin D on Graft-versus-Host DiseaseRodríguez Gil, AlfonsoCarrillo-Cruz, EstrellaMarrero-Cepeda, CristinaRodríguez, GuillermoPérez Simón, José AntonioVitamin DCalcifediolCalcitriolGraft-versus-host diseaseVitamin D receptor (VDR)The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results were confirmed in a prospective cohort trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies was also explored. Considering this dual effect on both the immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be useful in this setting to decrease both graft-versus-host disease and relapse rates.MDPIFisiología Médica y BiofísicaMedicina2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/139395https://doi.org/10.3390/biomedicines10050987reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésBiomedicines, 10 (5), 987.https://www.mdpi.com/2227-9059/10/5/987info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1393952026-06-17T12:51:07Z
dc.title.none.fl_str_mv Effect of Vitamin D on Graft-versus-Host Disease
title Effect of Vitamin D on Graft-versus-Host Disease
spellingShingle Effect of Vitamin D on Graft-versus-Host Disease
Rodríguez Gil, Alfonso
Vitamin D
Calcifediol
Calcitriol
Graft-versus-host disease
Vitamin D receptor (VDR)
title_short Effect of Vitamin D on Graft-versus-Host Disease
title_full Effect of Vitamin D on Graft-versus-Host Disease
title_fullStr Effect of Vitamin D on Graft-versus-Host Disease
title_full_unstemmed Effect of Vitamin D on Graft-versus-Host Disease
title_sort Effect of Vitamin D on Graft-versus-Host Disease
dc.creator.none.fl_str_mv Rodríguez Gil, Alfonso
Carrillo-Cruz, Estrella
Marrero-Cepeda, Cristina
Rodríguez, Guillermo
Pérez Simón, José Antonio
author Rodríguez Gil, Alfonso
author_facet Rodríguez Gil, Alfonso
Carrillo-Cruz, Estrella
Marrero-Cepeda, Cristina
Rodríguez, Guillermo
Pérez Simón, José Antonio
author_role author
author2 Carrillo-Cruz, Estrella
Marrero-Cepeda, Cristina
Rodríguez, Guillermo
Pérez Simón, José Antonio
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Fisiología Médica y Biofísica
Medicina
dc.subject.none.fl_str_mv Vitamin D
Calcifediol
Calcitriol
Graft-versus-host disease
Vitamin D receptor (VDR)
topic Vitamin D
Calcifediol
Calcitriol
Graft-versus-host disease
Vitamin D receptor (VDR)
description The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results were confirmed in a prospective cohort trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies was also explored. Considering this dual effect on both the immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be useful in this setting to decrease both graft-versus-host disease and relapse rates.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/139395
https://doi.org/10.3390/biomedicines10050987
url https://hdl.handle.net/11441/139395
https://doi.org/10.3390/biomedicines10050987
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biomedicines, 10 (5), 987.
https://www.mdpi.com/2227-9059/10/5/987
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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