Production of Fumaric Acid by Rhizopus arrhizus NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess

Fumaric acid is a promising monomer to obtain biomass-based polyesters and polyamides, and it is mainly produced by fungi of the Rhizopus genus in medium to high titters. The use of glucose, a main component of starchy and cellulosic food waste, as carbon source, together with a low-nitrogen source...

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Detalles Bibliográficos
Autores: Martín Domínguez, Víctor, Aleman Cabrera, Paula I, Eidt, Laslo, Pruesse, Ulf, Kuenz, Anja, Ladero Galán, Miguel, Santos Mazorra, Victoria Eugenia
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/72322
Acceso en línea:https://hdl.handle.net/20.500.14352/72322
Access Level:acceso abierto
Palabra clave:66.0
fumaric acid
Rhizopus arrhizus
kinetic modelling
fermentation
Ingeniería química
3303 Ingeniería y Tecnología Químicas
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repository_id_str
spelling Production of Fumaric Acid by Rhizopus arrhizus NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the BioprocessMartín Domínguez, VíctorAleman Cabrera, Paula IEidt, LasloPruesse, UlfKuenz, AnjaLadero Galán, MiguelSantos Mazorra, Victoria Eugenia66.0fumaric acidRhizopus arrhizuskinetic modellingfermentationIngeniería química3303 Ingeniería y Tecnología QuímicasFumaric acid is a promising monomer to obtain biomass-based polyesters and polyamides, and it is mainly produced by fungi of the Rhizopus genus in medium to high titters. The use of glucose, a main component of starchy and cellulosic food waste, as carbon source, together with a low-nitrogen source concentration, is a promising route to reduce process costs. In this work, the effects of nitrogen and carbonate sources on Rhizopus arrhizus NRRL 1526 morphology and fumaric acid productivity were analysed, simplifying the traditional production broth composition. Moreover, a non-structured, non-segregated kinetic model was proposed and fitted to concentration data of all relevant components obtained in batches performed in triplicate with the selected production broth at 34 °C and 200 rpm in an orbital shaker.MDPIUniversidad Complutense de Madrid20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/72322reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/723222026-06-02T12:44:21Z
dc.title.none.fl_str_mv Production of Fumaric Acid by Rhizopus arrhizus NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess
title Production of Fumaric Acid by Rhizopus arrhizus NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess
spellingShingle Production of Fumaric Acid by Rhizopus arrhizus NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess
Martín Domínguez, Víctor
66.0
fumaric acid
Rhizopus arrhizus
kinetic modelling
fermentation
Ingeniería química
3303 Ingeniería y Tecnología Químicas
title_short Production of Fumaric Acid by Rhizopus arrhizus NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess
title_full Production of Fumaric Acid by Rhizopus arrhizus NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess
title_fullStr Production of Fumaric Acid by Rhizopus arrhizus NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess
title_full_unstemmed Production of Fumaric Acid by Rhizopus arrhizus NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess
title_sort Production of Fumaric Acid by Rhizopus arrhizus NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess
dc.creator.none.fl_str_mv Martín Domínguez, Víctor
Aleman Cabrera, Paula I
Eidt, Laslo
Pruesse, Ulf
Kuenz, Anja
Ladero Galán, Miguel
Santos Mazorra, Victoria Eugenia
author Martín Domínguez, Víctor
author_facet Martín Domínguez, Víctor
Aleman Cabrera, Paula I
Eidt, Laslo
Pruesse, Ulf
Kuenz, Anja
Ladero Galán, Miguel
Santos Mazorra, Victoria Eugenia
author_role author
author2 Aleman Cabrera, Paula I
Eidt, Laslo
Pruesse, Ulf
Kuenz, Anja
Ladero Galán, Miguel
Santos Mazorra, Victoria Eugenia
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 66.0
fumaric acid
Rhizopus arrhizus
kinetic modelling
fermentation
Ingeniería química
3303 Ingeniería y Tecnología Químicas
topic 66.0
fumaric acid
Rhizopus arrhizus
kinetic modelling
fermentation
Ingeniería química
3303 Ingeniería y Tecnología Químicas
description Fumaric acid is a promising monomer to obtain biomass-based polyesters and polyamides, and it is mainly produced by fungi of the Rhizopus genus in medium to high titters. The use of glucose, a main component of starchy and cellulosic food waste, as carbon source, together with a low-nitrogen source concentration, is a promising route to reduce process costs. In this work, the effects of nitrogen and carbonate sources on Rhizopus arrhizus NRRL 1526 morphology and fumaric acid productivity were analysed, simplifying the traditional production broth composition. Moreover, a non-structured, non-segregated kinetic model was proposed and fitted to concentration data of all relevant components obtained in batches performed in triplicate with the selected production broth at 34 °C and 200 rpm in an orbital shaker.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/72322
url https://hdl.handle.net/20.500.14352/72322
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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