Impact of very early antiretroviral therapy during acute HIV infection on long-term immunovirological outcomes

Acute HIV infection; Antiretroviral treatment; Immune recovery

Detalles Bibliográficos
Autores: Suanzes, Paula, Álvarez-López, Patricia, García Pérez, Jorge N., Monforte, Arnau, Arando Lasagabaster, Maider, Rodríguez Vázquez, Lucía, Planas Ribas, Bibiana, Burgos Cibrian, Joaquin, Curran Fàbregas, Adria, Navarro, Jordi, Rando Segura, Ariadna, Descalzo Jorro, Vicente, Buzon, Maria Jose, Falcó, Vicenç
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/10443
Acceso en línea:https://hdl.handle.net/11351/10443
Access Level:acceso abierto
Palabra clave:Antiretrovirals - Ús terapèutic
Infeccions per VIH - Tractament
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents::Anti-Retroviral Agents
Other subheadings::Other subheadings::/therapeutic use
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Other subheadings::Other subheadings::Other subheadings::/drug therapy
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricos::antirretrovirales
Otros calificadores::Otros calificadores::/uso terapéutico
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
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oai_identifier_str oai:recercat.cat:11351/10443
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Impact of very early antiretroviral therapy during acute HIV infection on long-term immunovirological outcomes
title Impact of very early antiretroviral therapy during acute HIV infection on long-term immunovirological outcomes
spellingShingle Impact of very early antiretroviral therapy during acute HIV infection on long-term immunovirological outcomes
Suanzes, Paula
Antiretrovirals - Ús terapèutic
Infeccions per VIH - Tractament
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents::Anti-Retroviral Agents
Other subheadings::Other subheadings::/therapeutic use
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Other subheadings::Other subheadings::Other subheadings::/drug therapy
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricos::antirretrovirales
Otros calificadores::Otros calificadores::/uso terapéutico
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
title_short Impact of very early antiretroviral therapy during acute HIV infection on long-term immunovirological outcomes
title_full Impact of very early antiretroviral therapy during acute HIV infection on long-term immunovirological outcomes
title_fullStr Impact of very early antiretroviral therapy during acute HIV infection on long-term immunovirological outcomes
title_full_unstemmed Impact of very early antiretroviral therapy during acute HIV infection on long-term immunovirological outcomes
title_sort Impact of very early antiretroviral therapy during acute HIV infection on long-term immunovirological outcomes
dc.creator.none.fl_str_mv Suanzes, Paula
Álvarez-López, Patricia
García Pérez, Jorge N.
Monforte, Arnau
Arando Lasagabaster, Maider
Rodríguez Vázquez, Lucía
Planas Ribas, Bibiana
Burgos Cibrian, Joaquin
Curran Fàbregas, Adria
Navarro, Jordi
Rando Segura, Ariadna
Descalzo Jorro, Vicente
Buzon, Maria Jose
Falcó, Vicenç
author Suanzes, Paula
author_facet Suanzes, Paula
Álvarez-López, Patricia
García Pérez, Jorge N.
Monforte, Arnau
Arando Lasagabaster, Maider
Rodríguez Vázquez, Lucía
Planas Ribas, Bibiana
Burgos Cibrian, Joaquin
Curran Fàbregas, Adria
Navarro, Jordi
Rando Segura, Ariadna
Descalzo Jorro, Vicente
Buzon, Maria Jose
Falcó, Vicenç
author_role author
author2 Álvarez-López, Patricia
García Pérez, Jorge N.
Monforte, Arnau
Arando Lasagabaster, Maider
Rodríguez Vázquez, Lucía
Planas Ribas, Bibiana
Burgos Cibrian, Joaquin
Curran Fàbregas, Adria
Navarro, Jordi
Rando Segura, Ariadna
Descalzo Jorro, Vicente
Buzon, Maria Jose
Falcó, Vicenç
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Suanzes P, Burgos J, Falcó V] Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Malalties Infeccioses, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Navarro J, Álvarez-López P, García J, Descalzo V, Monforte A, Arando M, Curran A] Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Malalties Infeccioses, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Rando-Segura A] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Rodríguez L, Planas B, Buzón MJ] Grup de Recerca en Malalties Infeccioses, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Antiretrovirals - Ús terapèutic
Infeccions per VIH - Tractament
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents::Anti-Retroviral Agents
Other subheadings::Other subheadings::/therapeutic use
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Other subheadings::Other subheadings::Other subheadings::/drug therapy
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricos::antirretrovirales
Otros calificadores::Otros calificadores::/uso terapéutico
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
topic Antiretrovirals - Ús terapèutic
Infeccions per VIH - Tractament
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents::Anti-Retroviral Agents
Other subheadings::Other subheadings::/therapeutic use
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Other subheadings::Other subheadings::Other subheadings::/drug therapy
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricos::antirretrovirales
Otros calificadores::Otros calificadores::/uso terapéutico
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
description Acute HIV infection; Antiretroviral treatment; Immune recovery
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/10443
url https://hdl.handle.net/11351/10443
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Infectious Diseases;136
https://doi.org/10.1016/j.ijid.2023.09.009
info:eu-repo/grantAgreement/ES/PE2017-2020/PI20%2F00823
info:eu-repo/grantAgreement/ES/PEICTI2021-2023/CPII22%2F00005
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409913095061504
spelling Impact of very early antiretroviral therapy during acute HIV infection on long-term immunovirological outcomesSuanzes, PaulaÁlvarez-López, PatriciaGarcía Pérez, Jorge N.Monforte, ArnauArando Lasagabaster, MaiderRodríguez Vázquez, LucíaPlanas Ribas, BibianaBurgos Cibrian, JoaquinCurran Fàbregas, AdriaNavarro, JordiRando Segura, AriadnaDescalzo Jorro, VicenteBuzon, Maria JoseFalcó, VicençAntiretrovirals - Ús terapèuticInfeccions per VIH - TractamentCHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents::Anti-Retroviral AgentsOther subheadings::Other subheadings::/therapeutic useDISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV InfectionsOther subheadings::Other subheadings::Other subheadings::/drug therapyCOMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricos::antirretroviralesOtros calificadores::Otros calificadores::/uso terapéuticoENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIHOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaAcute HIV infection; Antiretroviral treatment; Immune recoveryInfección aguda por VIH; Tratamiento antirretroviral; Recuperación inmunitariaInfecció aguda per VIH; Tractament antiretroviral; Recuperació immunitàriaObjectives We aimed to determine if starting antiretroviral therapy (ART) in the first 30 days after acquiring HIV infection has an impact on immunovirological response. Methods Observational, ambispective study including 147 patients with confirmed acute HIV infection (January/1995-August/2022). ART was defined as very early (≤30 days after the estimated date of infection), early (31-180 days), and late (>180 days). We compared time to viral suppression (viral load [VL] <50 copies/ml) and immune recovery (IR) (CD4+/CD8+ ratio ≥1) according to the timing and type of ART using survival analysis. Results ART was started in 140 (95.2%) patients. ART was very early in 24 (17.1%), early in 77 (55.0%), and late in 39 (27.9%) cases. Integrase strand transfer inhibitor (INSTI)-based regimens were the most used in both the overall population (65%) and the very early ART group (23/24, 95.8%). Median HIV VL and CD4+/CD8+ ratio pre-ART were higher in the very early ART group (P <0.05). Patients in the very early and early ART groups and treated with INSTI-based regimens achieved IR earlier (P <0.05). Factors associated with faster IR were the CD4+/CD8+ ratio pre-ART (hazard ratio: 9.3, 95% CI: 3.1-27.8, P <0.001) and INSTI-based regimens (hazard ratio: 2.4, 95% CI: 1.3-4.2, P = 0.003). Conclusions The strongest predictors of IR in patients who start ART during AHI are the CD4+/CD8+ ratio pre-ART and INSTI-based ART regimens.This work was founded by Instituto de Salud Carlos III (Acción Estratégica en Salud) and Fondo Europeo de Desarrollo Regional (FEDER) through grant PI20/00823. The study was also supported by the Spanish Network for AIDS Research (RIS) through the Instituto de Salud Carlos III – Red Temática de Investigación Cooperativa en Sida (RD06/006, RD12/0017/0018 and RD16/0002/0006) as part of the Plan Nacional R+D+I and by ISCIII Subdirección General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER). For this project, PS has received a grant from the Catalan Society of Infectious Diseases and Clinical Microbiology (SCMIMC) funded by ViiV Healthcare. MJB is supported by the Miguel Servet program funded by the Spanish Health Institute Carlos III (CPII22/00005). The funders had no role in the study design, data collection, and interpretation, or the decision to submit the work for publication.ElsevierInstitut Català de la Salut[Suanzes P, Burgos J, Falcó V] Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Malalties Infeccioses, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Navarro J, Álvarez-López P, García J, Descalzo V, Monforte A, Arando M, Curran A] Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Malalties Infeccioses, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Rando-Segura A] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Rodríguez L, Planas B, Buzón MJ] Grup de Recerca en Malalties Infeccioses, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/10443Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInternational Journal of Infectious Diseases;136https://doi.org/10.1016/j.ijid.2023.09.009info:eu-repo/grantAgreement/ES/PE2017-2020/PI20%2F00823info:eu-repo/grantAgreement/ES/PEICTI2021-2023/CPII22%2F00005Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/104432026-05-29T05:05:01Z
score 15.812429

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