APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells

Glioblastoma is the most malignant brain tumor and presents high resistance to chemotherapy and radiotherapy. Surgery, radiotherapy and chemotherapy with temozolomide are the only treatments against this tumor. New targeted therapies, including epigenetic modulators such as 3‑deazaneplanocin A (DZ‑N...

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Authors: De-La-Rosa, J. (Javier)|||/items/d420f6f9-e470-4a26-8fb9-4c419c32a40a, Urdiciain-Ezpeleta, A. (Alejandro)|||/items/7173bee2-0d3d-4431-a892-d92d60c667b0, Zelaya, M.V. (María Victoria)|||/items/b17ebd92-1f01-4512-b71f-4f05874ca7b3, Zazpe, I. (Idoya)|||/items/0b5eae6f-50f8-41ed-a4c6-d0c071a44858, Meléndez, B. (Bárbara)|||/items/9c1f8587-8f9d-4f08-b10e-91b3670a0ffc, Rey, J.A. (Juan A.)|||/items/b33f46ba-e920-49a9-af7e-1d6566759c16, Idoate, M.A. (Miguel Ángel)|||/items/7b905180-f34f-450d-934f-8bf7652f84d3, Saez-Castresana, J. (Javier)|||/items/52f31ab0-8555-470d-af21-e677a1b3eff8
Format: article
Publication Date:2021
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/68392
Online Access:https://hdl.handle.net/10171/68392
Access Level:Open access
Keyword:APR-246
3-deazaneplanocin A
Panobinostat
Temozolomide
Synergy
Glioblastoma
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network_acronym_str ES
network_name_str España
repository_id_str
spelling APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cellsDe-La-Rosa, J. (Javier)|||/items/d420f6f9-e470-4a26-8fb9-4c419c32a40aUrdiciain-Ezpeleta, A. (Alejandro)|||/items/7173bee2-0d3d-4431-a892-d92d60c667b0Zelaya, M.V. (María Victoria)|||/items/b17ebd92-1f01-4512-b71f-4f05874ca7b3Zazpe, I. (Idoya)|||/items/0b5eae6f-50f8-41ed-a4c6-d0c071a44858Meléndez, B. (Bárbara)|||/items/9c1f8587-8f9d-4f08-b10e-91b3670a0ffcRey, J.A. (Juan A.)|||/items/b33f46ba-e920-49a9-af7e-1d6566759c16Idoate, M.A. (Miguel Ángel)|||/items/7b905180-f34f-450d-934f-8bf7652f84d3Saez-Castresana, J. (Javier)|||/items/52f31ab0-8555-470d-af21-e677a1b3eff8APR-2463-deazaneplanocin APanobinostatTemozolomideSynergyGlioblastomaGlioblastoma is the most malignant brain tumor and presents high resistance to chemotherapy and radiotherapy. Surgery, radiotherapy and chemotherapy with temozolomide are the only treatments against this tumor. New targeted therapies, including epigenetic modulators such as 3‑deazaneplanocin A (DZ‑Nep; an EZH2 inhibitor) and panobinostat (a histone deacetylase inhibitor) are being tested in vitro, together with temozolomide. The present study combined APR‑246 with DZ‑Nep, panobinostat and teomozolomide in order to explore the possibility of restoring p53 function in mutated cases of glioblastoma. Following the Chou‑Talalay method it was demonstrated that APR‑246 acts in an additive manner together with the other compounds, reducing clonogenicity and inducing apoptosis in glioblastoma cells independently of p53 status.SpandidosDadun. Depósito Académico Digital Universidad de Navarra20242024-01-1720212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/68392reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/683922026-06-21T12:47:57Z
dc.title.none.fl_str_mv APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells
title APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells
spellingShingle APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells
De-La-Rosa, J. (Javier)|||/items/d420f6f9-e470-4a26-8fb9-4c419c32a40a
APR-246
3-deazaneplanocin A
Panobinostat
Temozolomide
Synergy
Glioblastoma
title_short APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells
title_full APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells
title_fullStr APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells
title_full_unstemmed APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells
title_sort APR-246 combined with 3-deazaneplanocin A, panobinostat or temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells
dc.creator.none.fl_str_mv De-La-Rosa, J. (Javier)|||/items/d420f6f9-e470-4a26-8fb9-4c419c32a40a
Urdiciain-Ezpeleta, A. (Alejandro)|||/items/7173bee2-0d3d-4431-a892-d92d60c667b0
Zelaya, M.V. (María Victoria)|||/items/b17ebd92-1f01-4512-b71f-4f05874ca7b3
Zazpe, I. (Idoya)|||/items/0b5eae6f-50f8-41ed-a4c6-d0c071a44858
Meléndez, B. (Bárbara)|||/items/9c1f8587-8f9d-4f08-b10e-91b3670a0ffc
Rey, J.A. (Juan A.)|||/items/b33f46ba-e920-49a9-af7e-1d6566759c16
Idoate, M.A. (Miguel Ángel)|||/items/7b905180-f34f-450d-934f-8bf7652f84d3
Saez-Castresana, J. (Javier)|||/items/52f31ab0-8555-470d-af21-e677a1b3eff8
author De-La-Rosa, J. (Javier)|||/items/d420f6f9-e470-4a26-8fb9-4c419c32a40a
author_facet De-La-Rosa, J. (Javier)|||/items/d420f6f9-e470-4a26-8fb9-4c419c32a40a
Urdiciain-Ezpeleta, A. (Alejandro)|||/items/7173bee2-0d3d-4431-a892-d92d60c667b0
Zelaya, M.V. (María Victoria)|||/items/b17ebd92-1f01-4512-b71f-4f05874ca7b3
Zazpe, I. (Idoya)|||/items/0b5eae6f-50f8-41ed-a4c6-d0c071a44858
Meléndez, B. (Bárbara)|||/items/9c1f8587-8f9d-4f08-b10e-91b3670a0ffc
Rey, J.A. (Juan A.)|||/items/b33f46ba-e920-49a9-af7e-1d6566759c16
Idoate, M.A. (Miguel Ángel)|||/items/7b905180-f34f-450d-934f-8bf7652f84d3
Saez-Castresana, J. (Javier)|||/items/52f31ab0-8555-470d-af21-e677a1b3eff8
author_role author
author2 Urdiciain-Ezpeleta, A. (Alejandro)|||/items/7173bee2-0d3d-4431-a892-d92d60c667b0
Zelaya, M.V. (María Victoria)|||/items/b17ebd92-1f01-4512-b71f-4f05874ca7b3
Zazpe, I. (Idoya)|||/items/0b5eae6f-50f8-41ed-a4c6-d0c071a44858
Meléndez, B. (Bárbara)|||/items/9c1f8587-8f9d-4f08-b10e-91b3670a0ffc
Rey, J.A. (Juan A.)|||/items/b33f46ba-e920-49a9-af7e-1d6566759c16
Idoate, M.A. (Miguel Ángel)|||/items/7b905180-f34f-450d-934f-8bf7652f84d3
Saez-Castresana, J. (Javier)|||/items/52f31ab0-8555-470d-af21-e677a1b3eff8
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv APR-246
3-deazaneplanocin A
Panobinostat
Temozolomide
Synergy
Glioblastoma
topic APR-246
3-deazaneplanocin A
Panobinostat
Temozolomide
Synergy
Glioblastoma
description Glioblastoma is the most malignant brain tumor and presents high resistance to chemotherapy and radiotherapy. Surgery, radiotherapy and chemotherapy with temozolomide are the only treatments against this tumor. New targeted therapies, including epigenetic modulators such as 3‑deazaneplanocin A (DZ‑Nep; an EZH2 inhibitor) and panobinostat (a histone deacetylase inhibitor) are being tested in vitro, together with temozolomide. The present study combined APR‑246 with DZ‑Nep, panobinostat and teomozolomide in order to explore the possibility of restoring p53 function in mutated cases of glioblastoma. Following the Chou‑Talalay method it was demonstrated that APR‑246 acts in an additive manner together with the other compounds, reducing clonogenicity and inducing apoptosis in glioblastoma cells independently of p53 status.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
2024
2024-01-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/68392
url https://hdl.handle.net/10171/68392
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Spandidos
publisher.none.fl_str_mv Spandidos
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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