Obstructive sleep apnea: in search of precision

Introduction: Obstructive sleep apnea (OSA) is a highly prevalent condition that is viewed as a major global health concern, while affecting approximately 10% of the middle-aged population. OSA is a chronic disease that has been conclusively associated with poor quality of life, cognitive impairment...

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Detalles Bibliográficos
Autores: Sánchez de la Torre, Manuel, Gozal, David
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/71147
Acceso en línea:https://doi.org/10.1080/23808993.2017.1361319
http://hdl.handle.net/10459.1/71147
Access Level:acceso abierto
Palabra clave:Sleep apnea
OSA
CPAP
Precision medicine
Personalized medicine
Sleep health
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spelling Obstructive sleep apnea: in search of precisionSánchez de la Torre, ManuelGozal, DavidSleep apneaOSACPAPPrecision medicinePersonalized medicineSleep healthIntroduction: Obstructive sleep apnea (OSA) is a highly prevalent condition that is viewed as a major global health concern, while affecting approximately 10% of the middle-aged population. OSA is a chronic disease that has been conclusively associated with poor quality of life, cognitive impairments and mood alterations, enhanced cardiovascular and metabolic morbidity, thereby leading to marked increments in healthcare costs. Areas covered: The authors have reviewed the current evidence on the pathophysiology of OSA and its consequences, the heterogeneity of its phenotypic expression, the current therapeutic applications and their efficacy, and the implications for diagnosis, treatment and follow-up strategies in the context of the clinical management of OSA. Expert commentary: Personalized medicine in OSA identifies different needs and approaches: (i) phenotyping and defining the different and segregated clusters of OSA patients whose recognition may improve prognostic predictions and guide therapeutic strategies; (ii) to further characterize and predict the impact of OSA and its treatment, particularly revolving around mortality and the processes closely related to ageing (cardiovascular diseases, cancer and neurocognitive diseases); (iii) the introduction of new technologies including telemedicine that have shown promise in the implementation of personalized medicine approaches.This paper was funded by National Institutes of Health grant HL-130984 (Leila Kheirandish-Gozal, Principal Investigator).Taylor & Francis202120212017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttps://doi.org/10.1080/23808993.2017.1361319http://hdl.handle.net/10459.1/71147http://hdl.handle.net/10459.1/71147reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1080/23808993.2017.1361319Expert Review of Precision Medicine and Drug Development, 2017, vol. 2, núm. 4, p. 217-228cc-by-nc (c) Sánchez de la Torre et al., 2017info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/oai:recercat.cat:10459.1/711472026-05-29T05:05:01Z
dc.title.none.fl_str_mv Obstructive sleep apnea: in search of precision
title Obstructive sleep apnea: in search of precision
spellingShingle Obstructive sleep apnea: in search of precision
Sánchez de la Torre, Manuel
Sleep apnea
OSA
CPAP
Precision medicine
Personalized medicine
Sleep health
title_short Obstructive sleep apnea: in search of precision
title_full Obstructive sleep apnea: in search of precision
title_fullStr Obstructive sleep apnea: in search of precision
title_full_unstemmed Obstructive sleep apnea: in search of precision
title_sort Obstructive sleep apnea: in search of precision
dc.creator.none.fl_str_mv Sánchez de la Torre, Manuel
Gozal, David
author Sánchez de la Torre, Manuel
author_facet Sánchez de la Torre, Manuel
Gozal, David
author_role author
author2 Gozal, David
author2_role author
dc.subject.none.fl_str_mv Sleep apnea
OSA
CPAP
Precision medicine
Personalized medicine
Sleep health
topic Sleep apnea
OSA
CPAP
Precision medicine
Personalized medicine
Sleep health
description Introduction: Obstructive sleep apnea (OSA) is a highly prevalent condition that is viewed as a major global health concern, while affecting approximately 10% of the middle-aged population. OSA is a chronic disease that has been conclusively associated with poor quality of life, cognitive impairments and mood alterations, enhanced cardiovascular and metabolic morbidity, thereby leading to marked increments in healthcare costs. Areas covered: The authors have reviewed the current evidence on the pathophysiology of OSA and its consequences, the heterogeneity of its phenotypic expression, the current therapeutic applications and their efficacy, and the implications for diagnosis, treatment and follow-up strategies in the context of the clinical management of OSA. Expert commentary: Personalized medicine in OSA identifies different needs and approaches: (i) phenotyping and defining the different and segregated clusters of OSA patients whose recognition may improve prognostic predictions and guide therapeutic strategies; (ii) to further characterize and predict the impact of OSA and its treatment, particularly revolving around mortality and the processes closely related to ageing (cardiovascular diseases, cancer and neurocognitive diseases); (iii) the introduction of new technologies including telemedicine that have shown promise in the implementation of personalized medicine approaches.
publishDate 2017
dc.date.none.fl_str_mv 2017
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1080/23808993.2017.1361319
http://hdl.handle.net/10459.1/71147
http://hdl.handle.net/10459.1/71147
url https://doi.org/10.1080/23808993.2017.1361319
http://hdl.handle.net/10459.1/71147
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1080/23808993.2017.1361319
Expert Review of Precision Medicine and Drug Development, 2017, vol. 2, núm. 4, p. 217-228
dc.rights.none.fl_str_mv cc-by-nc (c) Sánchez de la Torre et al., 2017
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0/
rights_invalid_str_mv cc-by-nc (c) Sánchez de la Torre et al., 2017
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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