Thermodynamic and Kinetic Aspects of Calcium Oxalate Crystallization and Renal Lithiasis

Thermodynamic factors (supersaturation of substances that form crystals) and kinetic factors (heterogeneous nucleants and crystallization inhibitors) affect the formation of crystals and stones in the urinary tract. We studied the effect of five different polyhydroxycarboxylic acids and phytate on t...

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Detalhes bibliográficos
Autores: Dietrich, Jaume, Costa-Bauzà, Antonia, Grases, Fèlix
Tipo de documento: artigo
Data de publicação:2025
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositório:Docusalut
Idioma:inglês
OAI Identifier:oai:docusalut.com:20.500.13003/25872
Acesso em linha:https://hdl.handle.net/20.500.13003/25872
Access Level:Acceso aberto
Palavra-chave:Calcium Oxalate
Crystallization
Oxalato de Calcio
Cristalización
calcium oxalate
crystallization
thermodynamics effects
kinetic effects
hydroxycitrate
phytate
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spelling Thermodynamic and Kinetic Aspects of Calcium Oxalate Crystallization and Renal LithiasisDietrich, JaumeCosta-Bauzà, AntoniaGrases, FèlixCalcium OxalateCrystallizationOxalato de CalcioCristalizacióncalcium oxalatecrystallizationthermodynamics effectskinetic effectshydroxycitratephytateThermodynamic factors (supersaturation of substances that form crystals) and kinetic factors (heterogeneous nucleants and crystallization inhibitors) affect the formation of crystals and stones in the urinary tract. We studied the effect of five different polyhydroxycarboxylic acids and phytate on the formation of calcium oxalate crystals in artificial urine. All tested molecules are known to inhibit the crystallization of this calcium salt, and to also form complexes with calcium ions. Considering the typical concentration of polyhydroxycarboxylic acids in urine (similar to that of the calcium ion) and their ability to inhibit crystallization, their most important effect is the capacity to complex calcium—a thermodynamic effect. For phytate and its metabolites, which are present in concentrations much lower than that of the calcium ion, the most important effect is as a crystallization inhibitor—a kinetic effect. Among the five polyhydroxycarboxylic acids examined here, hydroxycitrate had the strongest complexing capacity, and the addition of phytate to hydroxycitrate led to greater inhibition of crystallization. Therefore, because oral consumption of hydroxycitrate does not increase the urinary pH, it is likely that the combined consumption of hydroxycitrate and phytate can provide certain benefits for patients with increased risk of developing calcium oxalate stones. We also discussed the effects of these different molecules on the different calcium oxalate stones, including papillary calcium oxalate monohydrate stones, cavity calcium oxalate monohydrate stones, calcium oxalate dihydrate stones, and mixed calcium oxalate dihydrate/hydroxyapatite stones.MDPI20252025-08-0720252025-08-07research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/25872reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-104331RB-I00 ESTUDIO DE LOS MECANISMOS DE FORMACION DE DEPOSITOS SOBRE CATETERES URETERALES DOBLE J Y DESARROLLO DE ESTRATEGIAS PROFILACTICASopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/258722026-06-22T12:44:07Z
dc.title.none.fl_str_mv Thermodynamic and Kinetic Aspects of Calcium Oxalate Crystallization and Renal Lithiasis
title Thermodynamic and Kinetic Aspects of Calcium Oxalate Crystallization and Renal Lithiasis
spellingShingle Thermodynamic and Kinetic Aspects of Calcium Oxalate Crystallization and Renal Lithiasis
Dietrich, Jaume
Calcium Oxalate
Crystallization
Oxalato de Calcio
Cristalización
calcium oxalate
crystallization
thermodynamics effects
kinetic effects
hydroxycitrate
phytate
title_short Thermodynamic and Kinetic Aspects of Calcium Oxalate Crystallization and Renal Lithiasis
title_full Thermodynamic and Kinetic Aspects of Calcium Oxalate Crystallization and Renal Lithiasis
title_fullStr Thermodynamic and Kinetic Aspects of Calcium Oxalate Crystallization and Renal Lithiasis
title_full_unstemmed Thermodynamic and Kinetic Aspects of Calcium Oxalate Crystallization and Renal Lithiasis
title_sort Thermodynamic and Kinetic Aspects of Calcium Oxalate Crystallization and Renal Lithiasis
dc.creator.none.fl_str_mv Dietrich, Jaume
Costa-Bauzà, Antonia
Grases, Fèlix
author Dietrich, Jaume
author_facet Dietrich, Jaume
Costa-Bauzà, Antonia
Grases, Fèlix
author_role author
author2 Costa-Bauzà, Antonia
Grases, Fèlix
author2_role author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Calcium Oxalate
Crystallization
Oxalato de Calcio
Cristalización
calcium oxalate
crystallization
thermodynamics effects
kinetic effects
hydroxycitrate
phytate
topic Calcium Oxalate
Crystallization
Oxalato de Calcio
Cristalización
calcium oxalate
crystallization
thermodynamics effects
kinetic effects
hydroxycitrate
phytate
description Thermodynamic factors (supersaturation of substances that form crystals) and kinetic factors (heterogeneous nucleants and crystallization inhibitors) affect the formation of crystals and stones in the urinary tract. We studied the effect of five different polyhydroxycarboxylic acids and phytate on the formation of calcium oxalate crystals in artificial urine. All tested molecules are known to inhibit the crystallization of this calcium salt, and to also form complexes with calcium ions. Considering the typical concentration of polyhydroxycarboxylic acids in urine (similar to that of the calcium ion) and their ability to inhibit crystallization, their most important effect is the capacity to complex calcium—a thermodynamic effect. For phytate and its metabolites, which are present in concentrations much lower than that of the calcium ion, the most important effect is as a crystallization inhibitor—a kinetic effect. Among the five polyhydroxycarboxylic acids examined here, hydroxycitrate had the strongest complexing capacity, and the addition of phytate to hydroxycitrate led to greater inhibition of crystallization. Therefore, because oral consumption of hydroxycitrate does not increase the urinary pH, it is likely that the combined consumption of hydroxycitrate and phytate can provide certain benefits for patients with increased risk of developing calcium oxalate stones. We also discussed the effects of these different molecules on the different calcium oxalate stones, including papillary calcium oxalate monohydrate stones, cavity calcium oxalate monohydrate stones, calcium oxalate dihydrate stones, and mixed calcium oxalate dihydrate/hydroxyapatite stones.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-08-07
2025
2025-08-07
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/25872
url https://hdl.handle.net/20.500.13003/25872
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-104331RB-I00 ESTUDIO DE LOS MECANISMOS DE FORMACION DE DEPOSITOS SOBRE CATETERES URETERALES DOBLE J Y DESARROLLO DE ESTRATEGIAS PROFILACTICAS
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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