Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandem...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/198674 |
| Acesso em linha: | https://hdl.handle.net/2445/198674 |
| Access Level: | acceso abierto |
| Palavra-chave: | Pandèmia de COVID-19, 2020- Infart de miocardi Mortalitat Factors d'edat en les malalties COVID-19 Pandemic, 2020- Myocardial infarction Mortality Age factors in disease |
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| dc.title.none.fl_str_mv |
Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
| title |
Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
| spellingShingle |
Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry De Luca, Giuseppe Pandèmia de COVID-19, 2020- Infart de miocardi Mortalitat Factors d'edat en les malalties COVID-19 Pandemic, 2020- Myocardial infarction Mortality Age factors in disease |
| title_short |
Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
| title_full |
Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
| title_fullStr |
Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
| title_full_unstemmed |
Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
| title_sort |
Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry |
| dc.creator.none.fl_str_mv |
De Luca, Giuseppe Algowhary, Magdy Uguz, Berat Oliveira, Dinaldo C. Ganyukov, Vladimir Busljetik, Oliver Cercek, Miha Okkels Jensen, Lisette Loh, Poay Huan Calmac, Lucian Roura i Ferrer, Gerard Quadros, Alexandre Milewski, Marek Scotto Di Uccio, Fortunato Von Birgelen, Clemens Versaci, Francesco Ten Berg, Jurrien Casella, Gianni Wong Sung Lung, Aaron Kala, Petr Díez Gil, José Luis Carrillo, Xavier Dirksen, Maurits Becerra Munoz, Victor Kang-yin Lee, Michael Arifa Juzar, Dafsah De Moura Joaquim, Rodrigo Paladino, Roberto Milicic, Davor Davlouros, Periklis Bakraceski, Nikola Zilio, Filippo Donazzan, Luca Kraaijeveld, Adriaan Galasso, Gennaro Arpad, Lux Marinucci, Lucia Guiducci, Vincenzo Menichelli, Maurizio Scoccia, Alessandra Hatice Yamac, Aylin Ugur Mert, Kadir Flores Rios, Xacobe Kovarnik, Tomas Kidawa, Michal Moreu, Josè Flavien, Vincent Fabris, Enrico Lozano Martínez-Luengas, Iñigo Boccalatte, Marco Bosa Ojeda, Francisco Arellano Serrano, Carlos Caiazzo, Gianluca Cirrincione, Giuseppe Kao, Hsien Li Sanchis Forés, Juan Vignali, Luigi Pereira, Helder Manzo Silberman, Stephane Ordoñez, Santiago Arat Özkan, Alev Scheller, Bruno Lehitola, Heidi Teles, Rui Mantis, Christos Antti, Ylitalo Brum Silveira, João António Zoni, Cesar Rodrigo Bessonov, Ivan Uccello, Giuseppe Kochiadakis, George Alexopulos, Dimitrios Uribe, Carlos E. Kanakakis, John Faurie, Benjamin Gabrielli, Gabriele Gutierrez Barrios, Alejandro Bachini, Juan Pablo Rocha, Alex Tam, Frankie C. C. Rodriguez, Alfredo Lukito, Antonia Anna Saint Joy, Veauthyelau Pessah, Gustavo Tuccillo, Andrea Ielasi, Alfonso Cortese, Giuliana Parodi, Guido Abed Burgadha, Mohammed Kedhi, Elvin Lamelas, Pablo Suryapranata, Harry Nardin, Matteo Verdoia, Monica |
| author |
De Luca, Giuseppe |
| author_facet |
De Luca, Giuseppe Algowhary, Magdy Uguz, Berat Oliveira, Dinaldo C. Ganyukov, Vladimir Busljetik, Oliver Cercek, Miha Okkels Jensen, Lisette Loh, Poay Huan Calmac, Lucian Roura i Ferrer, Gerard Quadros, Alexandre Milewski, Marek Scotto Di Uccio, Fortunato Von Birgelen, Clemens Versaci, Francesco Ten Berg, Jurrien Casella, Gianni Wong Sung Lung, Aaron Kala, Petr Díez Gil, José Luis Carrillo, Xavier Dirksen, Maurits Becerra Munoz, Victor Kang-yin Lee, Michael Arifa Juzar, Dafsah De Moura Joaquim, Rodrigo Paladino, Roberto Milicic, Davor Davlouros, Periklis Bakraceski, Nikola Zilio, Filippo Donazzan, Luca Kraaijeveld, Adriaan Galasso, Gennaro Arpad, Lux Marinucci, Lucia Guiducci, Vincenzo Menichelli, Maurizio Scoccia, Alessandra Hatice Yamac, Aylin Ugur Mert, Kadir Flores Rios, Xacobe Kovarnik, Tomas Kidawa, Michal Moreu, Josè Flavien, Vincent Fabris, Enrico Lozano Martínez-Luengas, Iñigo Boccalatte, Marco Bosa Ojeda, Francisco Arellano Serrano, Carlos Caiazzo, Gianluca Cirrincione, Giuseppe Kao, Hsien Li Sanchis Forés, Juan Vignali, Luigi Pereira, Helder Manzo Silberman, Stephane Ordoñez, Santiago Arat Özkan, Alev Scheller, Bruno Lehitola, Heidi Teles, Rui Mantis, Christos Antti, Ylitalo Brum Silveira, João António Zoni, Cesar Rodrigo Bessonov, Ivan Uccello, Giuseppe Kochiadakis, George Alexopulos, Dimitrios Uribe, Carlos E. Kanakakis, John Faurie, Benjamin Gabrielli, Gabriele Gutierrez Barrios, Alejandro Bachini, Juan Pablo Rocha, Alex Tam, Frankie C. C. Rodriguez, Alfredo Lukito, Antonia Anna Saint Joy, Veauthyelau Pessah, Gustavo Tuccillo, Andrea Ielasi, Alfonso Cortese, Giuliana Parodi, Guido Abed Burgadha, Mohammed Kedhi, Elvin Lamelas, Pablo Suryapranata, Harry Nardin, Matteo Verdoia, Monica |
| author_role |
author |
| author2 |
Algowhary, Magdy Uguz, Berat Oliveira, Dinaldo C. Ganyukov, Vladimir Busljetik, Oliver Cercek, Miha Okkels Jensen, Lisette Loh, Poay Huan Calmac, Lucian Roura i Ferrer, Gerard Quadros, Alexandre Milewski, Marek Scotto Di Uccio, Fortunato Von Birgelen, Clemens Versaci, Francesco Ten Berg, Jurrien Casella, Gianni Wong Sung Lung, Aaron Kala, Petr Díez Gil, José Luis Carrillo, Xavier Dirksen, Maurits Becerra Munoz, Victor Kang-yin Lee, Michael Arifa Juzar, Dafsah De Moura Joaquim, Rodrigo Paladino, Roberto Milicic, Davor Davlouros, Periklis Bakraceski, Nikola Zilio, Filippo Donazzan, Luca Kraaijeveld, Adriaan Galasso, Gennaro Arpad, Lux Marinucci, Lucia Guiducci, Vincenzo Menichelli, Maurizio Scoccia, Alessandra Hatice Yamac, Aylin Ugur Mert, Kadir Flores Rios, Xacobe Kovarnik, Tomas Kidawa, Michal Moreu, Josè Flavien, Vincent Fabris, Enrico Lozano Martínez-Luengas, Iñigo Boccalatte, Marco Bosa Ojeda, Francisco Arellano Serrano, Carlos Caiazzo, Gianluca Cirrincione, Giuseppe Kao, Hsien Li Sanchis Forés, Juan Vignali, Luigi Pereira, Helder Manzo Silberman, Stephane Ordoñez, Santiago Arat Özkan, Alev Scheller, Bruno Lehitola, Heidi Teles, Rui Mantis, Christos Antti, Ylitalo Brum Silveira, João António Zoni, Cesar Rodrigo Bessonov, Ivan Uccello, Giuseppe Kochiadakis, George Alexopulos, Dimitrios Uribe, Carlos E. Kanakakis, John Faurie, Benjamin Gabrielli, Gabriele Gutierrez Barrios, Alejandro Bachini, Juan Pablo Rocha, Alex Tam, Frankie C. C. Rodriguez, Alfredo Lukito, Antonia Anna Saint Joy, Veauthyelau Pessah, Gustavo Tuccillo, Andrea Ielasi, Alfonso Cortese, Giuliana Parodi, Guido Abed Burgadha, Mohammed Kedhi, Elvin Lamelas, Pablo Suryapranata, Harry Nardin, Matteo Verdoia, Monica |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Pandèmia de COVID-19, 2020- Infart de miocardi Mortalitat Factors d'edat en les malalties COVID-19 Pandemic, 2020- Myocardial infarction Mortality Age factors in disease |
| topic |
Pandèmia de COVID-19, 2020- Infart de miocardi Mortalitat Factors d'edat en les malalties COVID-19 Pandemic, 2020- Myocardial infarction Mortality Age factors in disease |
| description |
Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March-June 2019 and 2020. Patients were divided according to age (< or >= 75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825-0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24-1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05-1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023 2023 2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/198674 |
| url |
https://hdl.handle.net/2445/198674 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.3390/jcm12062116 Journal of Clinical Medicine, 2023, vol. 12, num. 6, p. 2116 https://doi.org/10.3390/jcm12062116 |
| dc.rights.none.fl_str_mv |
cc by (c) De Luca, Giuseppe et al., 2023 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc by (c) De Luca, Giuseppe et al., 2023 http://creativecommons.org/licenses/by/3.0/es/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
14 p. application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI AG |
| publisher.none.fl_str_mv |
MDPI AG |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869409866533044224 |
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Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 RegistryDe Luca, GiuseppeAlgowhary, MagdyUguz, BeratOliveira, Dinaldo C.Ganyukov, VladimirBusljetik, OliverCercek, MihaOkkels Jensen, LisetteLoh, Poay HuanCalmac, LucianRoura i Ferrer, GerardQuadros, AlexandreMilewski, MarekScotto Di Uccio, FortunatoVon Birgelen, ClemensVersaci, FrancescoTen Berg, JurrienCasella, GianniWong Sung Lung, AaronKala, PetrDíez Gil, José LuisCarrillo, XavierDirksen, MauritsBecerra Munoz, VictorKang-yin Lee, MichaelArifa Juzar, DafsahDe Moura Joaquim, RodrigoPaladino, RobertoMilicic, DavorDavlouros, PeriklisBakraceski, NikolaZilio, FilippoDonazzan, LucaKraaijeveld, AdriaanGalasso, GennaroArpad, LuxMarinucci, LuciaGuiducci, VincenzoMenichelli, MaurizioScoccia, AlessandraHatice Yamac, AylinUgur Mert, KadirFlores Rios, XacobeKovarnik, TomasKidawa, MichalMoreu, JosèFlavien, VincentFabris, EnricoLozano Martínez-Luengas, IñigoBoccalatte, MarcoBosa Ojeda, FranciscoArellano Serrano, CarlosCaiazzo, GianlucaCirrincione, GiuseppeKao, Hsien LiSanchis Forés, JuanVignali, LuigiPereira, HelderManzo Silberman, StephaneOrdoñez, SantiagoArat Özkan, AlevScheller, BrunoLehitola, HeidiTeles, RuiMantis, ChristosAntti, YlitaloBrum Silveira, João AntónioZoni, Cesar RodrigoBessonov, IvanUccello, GiuseppeKochiadakis, GeorgeAlexopulos, DimitriosUribe, Carlos E.Kanakakis, JohnFaurie, BenjaminGabrielli, GabrieleGutierrez Barrios, AlejandroBachini, Juan PabloRocha, AlexTam, Frankie C. C.Rodriguez, AlfredoLukito, Antonia AnnaSaint Joy, VeauthyelauPessah, GustavoTuccillo, AndreaIelasi, AlfonsoCortese, GiulianaParodi, GuidoAbed Burgadha, MohammedKedhi, ElvinLamelas, PabloSuryapranata, HarryNardin, MatteoVerdoia, MonicaPandèmia de COVID-19, 2020-Infart de miocardiMortalitatFactors d'edat en les malaltiesCOVID-19 Pandemic, 2020-Myocardial infarctionMortalityAge factors in diseaseBackground: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March-June 2019 and 2020. Patients were divided according to age (< or >= 75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825-0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24-1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05-1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic.MDPI AG2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/198674Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/jcm12062116Journal of Clinical Medicine, 2023, vol. 12, num. 6, p. 2116https://doi.org/10.3390/jcm12062116cc by (c) De Luca, Giuseppe et al., 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1986742026-05-29T05:05:01Z |
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15.811543 |