Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats
The toxicokinetics of glyphosate after single 100 mg kg−1 intravenous (i.v.) and 400 mg kg−1 oral doses were studied in rats. Serial blood samples were obtained after i.v. and oral administration. Plasma concentrations of glyphosate and its metabolite amiomethyl phosphonic acid (AMPA) were determine...
| Autores: | , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2009 |
| País: | España |
| Recursos: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/97992 |
| Acesso em linha: | https://hdl.handle.net/20.500.14352/97992 |
| Access Level: | acceso abierto |
| Palavra-chave: | 615.9 Glyphosate AMPA Plasma disposition Rats Ciencias Biomédicas 3214 Toxicología |
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Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in ratsAnadón Navarro, Arturo RamónMartínez Larrañaga, María RosaMartínez Caballero, María AranzazuCastellano Santos, Víctor JesúsMartínez Caballero, MartaMartín, M.T.Nozal, M.J.Bernal, J.L.615.9GlyphosateAMPAPlasma dispositionRatsCiencias Biomédicas3214 ToxicologíaThe toxicokinetics of glyphosate after single 100 mg kg−1 intravenous (i.v.) and 400 mg kg−1 oral doses were studied in rats. Serial blood samples were obtained after i.v. and oral administration. Plasma concentrations of glyphosate and its metabolite amiomethyl phosphonic acid (AMPA) were determined by HPLC method. After i.v. and oral administration, plasma concentration–time curves were best described by a two-compartment open model. For glyphosate, the elimination half-lives (T1/2β) from plasma were 9.99 h after i.v. and 14.38 h after oral administration. The total plasma clearance was not influenced by dose concentration or route and reached a value of 0.995 l h−1 kg−1. After i.v. administration, the apparent volume of distribution in the second compartment (V2) and volume of distribution at steady state (Vss) were 2.39 and 2.99 l kg−1, respectively, suggesting a considerable diffusion of the herbicide into tissues. After oral administration, glyphosate was partially and slowly absorbed with a Tmax of 5.16 h. The oral bioavailability of glyphosate was found to be 23.21%. Glyphosate was converted to AMPA. The metabolite AMPA represented 6.49% of the parent drug plasma concentrations. The maximum plasma concentrations of glyphosate and AMPA were 4.62 and 0.416 μg ml−1, respectively. The maximum plasma concentration of AMPA was achieved at 2.42 h. For AMPA, the elimination half-life (T1/2β) was 15.08 h after oral administration of glyphosate parent compound.ElsevierUniversidad Complutense de Madrid20092009-10-0820092009-10-08journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/97992reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/979922026-06-02T12:44:21Z |
| dc.title.none.fl_str_mv |
Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats |
| title |
Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats |
| spellingShingle |
Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats Anadón Navarro, Arturo Ramón 615.9 Glyphosate AMPA Plasma disposition Rats Ciencias Biomédicas 3214 Toxicología |
| title_short |
Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats |
| title_full |
Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats |
| title_fullStr |
Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats |
| title_full_unstemmed |
Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats |
| title_sort |
Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats |
| dc.creator.none.fl_str_mv |
Anadón Navarro, Arturo Ramón Martínez Larrañaga, María Rosa Martínez Caballero, María Aranzazu Castellano Santos, Víctor Jesús Martínez Caballero, Marta Martín, M.T. Nozal, M.J. Bernal, J.L. |
| author |
Anadón Navarro, Arturo Ramón |
| author_facet |
Anadón Navarro, Arturo Ramón Martínez Larrañaga, María Rosa Martínez Caballero, María Aranzazu Castellano Santos, Víctor Jesús Martínez Caballero, Marta Martín, M.T. Nozal, M.J. Bernal, J.L. |
| author_role |
author |
| author2 |
Martínez Larrañaga, María Rosa Martínez Caballero, María Aranzazu Castellano Santos, Víctor Jesús Martínez Caballero, Marta Martín, M.T. Nozal, M.J. Bernal, J.L. |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad Complutense de Madrid |
| dc.subject.none.fl_str_mv |
615.9 Glyphosate AMPA Plasma disposition Rats Ciencias Biomédicas 3214 Toxicología |
| topic |
615.9 Glyphosate AMPA Plasma disposition Rats Ciencias Biomédicas 3214 Toxicología |
| description |
The toxicokinetics of glyphosate after single 100 mg kg−1 intravenous (i.v.) and 400 mg kg−1 oral doses were studied in rats. Serial blood samples were obtained after i.v. and oral administration. Plasma concentrations of glyphosate and its metabolite amiomethyl phosphonic acid (AMPA) were determined by HPLC method. After i.v. and oral administration, plasma concentration–time curves were best described by a two-compartment open model. For glyphosate, the elimination half-lives (T1/2β) from plasma were 9.99 h after i.v. and 14.38 h after oral administration. The total plasma clearance was not influenced by dose concentration or route and reached a value of 0.995 l h−1 kg−1. After i.v. administration, the apparent volume of distribution in the second compartment (V2) and volume of distribution at steady state (Vss) were 2.39 and 2.99 l kg−1, respectively, suggesting a considerable diffusion of the herbicide into tissues. After oral administration, glyphosate was partially and slowly absorbed with a Tmax of 5.16 h. The oral bioavailability of glyphosate was found to be 23.21%. Glyphosate was converted to AMPA. The metabolite AMPA represented 6.49% of the parent drug plasma concentrations. The maximum plasma concentrations of glyphosate and AMPA were 4.62 and 0.416 μg ml−1, respectively. The maximum plasma concentration of AMPA was achieved at 2.42 h. For AMPA, the elimination half-life (T1/2β) was 15.08 h after oral administration of glyphosate parent compound. |
| publishDate |
2009 |
| dc.date.none.fl_str_mv |
2009 2009-10-08 2009 2009-10-08 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14352/97992 |
| url |
https://hdl.handle.net/20.500.14352/97992 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
| dc.source.none.fl_str_mv |
reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM) |
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Universidad Complutense de Madrid (UCM) |
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Docta Complutense |
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Docta Complutense |
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1869409844890435584 |
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15.300719 |