Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone - A microsomal enzyme inducer

Anguilla anguilla L. were exposed during 24 and 48 h to 2.7 μM β-naphthoflavone (BNF), a known microsomal enzyme inducer. The BNF effects on thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4) and cortisol plasma levels were investigated. Alterations on plasma glucose...

ver descrição completa

Detalhes bibliográficos
Autores: Teles, Mariana|||0000-0001-5525-4049, Oliveira, Miguel|||0000-0001-5404-7718, Pacheco, M. Guilherme Garcês|||0000-0003-0552-9643, Santos Maroño, Mauro|||0000-0002-6478-6570
Tipo de documento: artigo
Data de publicação:2005
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:324241
Acesso em linha:https://ddd.uab.cat/record/324241
https://dx.doi.org/urn:doi:10.1016/j.envint.2004.07.003
Access Level:Acceso aberto
Palavra-chave:Endocrine
Plasma
β-Naphthoflavone
id ES_66ca7936e100bbfc551d42e5ddfa9bdc
oai_identifier_str oai:ddd.uab.cat:324241
network_acronym_str ES
network_name_str España
repository_id_str
spelling Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone - A microsomal enzyme inducerTeles, Mariana|||0000-0001-5525-4049Oliveira, Miguel|||0000-0001-5404-7718Pacheco, M. Guilherme Garcês|||0000-0003-0552-9643Santos Maroño, Mauro|||0000-0002-6478-6570EndocrinePlasmaβ-NaphthoflavoneAnguilla anguilla L. were exposed during 24 and 48 h to 2.7 μM β-naphthoflavone (BNF), a known microsomal enzyme inducer. The BNF effects on thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4) and cortisol plasma levels were investigated. Alterations on plasma glucose and lactate levels were also measured as an indication of energy-mobilizing hormones alterations. BNF showed to be able to decrease significantly A. anguilla plasma T4 levels, whereas TSH, T3 and cortisol plasma remained constant. However, plasma glucose levels were significantly increased, demonstrating that intermediary metabolism has been affected. These results demonstrate that BNF a PAH-like compound alters the normal functioning of the hypothalamo-pituitary-thyroid (HPT) axis in A. anguilla. 22005-01-0120052005-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/324241https://dx.doi.org/urn:doi:10.1016/j.envint.2004.07.003reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3242412026-06-06T12:50:31Z
dc.title.none.fl_str_mv Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone - A microsomal enzyme inducer
title Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone - A microsomal enzyme inducer
spellingShingle Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone - A microsomal enzyme inducer
Teles, Mariana|||0000-0001-5525-4049
Endocrine
Plasma
β-Naphthoflavone
title_short Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone - A microsomal enzyme inducer
title_full Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone - A microsomal enzyme inducer
title_fullStr Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone - A microsomal enzyme inducer
title_full_unstemmed Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone - A microsomal enzyme inducer
title_sort Endocrine and metabolic changes in Anguilla anguilla L. following exposure to β-naphthoflavone - A microsomal enzyme inducer
dc.creator.none.fl_str_mv Teles, Mariana|||0000-0001-5525-4049
Oliveira, Miguel|||0000-0001-5404-7718
Pacheco, M. Guilherme Garcês|||0000-0003-0552-9643
Santos Maroño, Mauro|||0000-0002-6478-6570
author Teles, Mariana|||0000-0001-5525-4049
author_facet Teles, Mariana|||0000-0001-5525-4049
Oliveira, Miguel|||0000-0001-5404-7718
Pacheco, M. Guilherme Garcês|||0000-0003-0552-9643
Santos Maroño, Mauro|||0000-0002-6478-6570
author_role author
author2 Oliveira, Miguel|||0000-0001-5404-7718
Pacheco, M. Guilherme Garcês|||0000-0003-0552-9643
Santos Maroño, Mauro|||0000-0002-6478-6570
author2_role author
author
author
dc.subject.none.fl_str_mv Endocrine
Plasma
β-Naphthoflavone
topic Endocrine
Plasma
β-Naphthoflavone
description Anguilla anguilla L. were exposed during 24 and 48 h to 2.7 μM β-naphthoflavone (BNF), a known microsomal enzyme inducer. The BNF effects on thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4) and cortisol plasma levels were investigated. Alterations on plasma glucose and lactate levels were also measured as an indication of energy-mobilizing hormones alterations. BNF showed to be able to decrease significantly A. anguilla plasma T4 levels, whereas TSH, T3 and cortisol plasma remained constant. However, plasma glucose levels were significantly increased, demonstrating that intermediary metabolism has been affected. These results demonstrate that BNF a PAH-like compound alters the normal functioning of the hypothalamo-pituitary-thyroid (HPT) axis in A. anguilla.
publishDate 2005
dc.date.none.fl_str_mv 2
2005-01-01
2005
2005-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/324241
https://dx.doi.org/urn:doi:10.1016/j.envint.2004.07.003
url https://ddd.uab.cat/record/324241
https://dx.doi.org/urn:doi:10.1016/j.envint.2004.07.003
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409842991464448
score 15,811543

Registros relacionados