Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia

Coenzyme Q10 (CoQ) is a ubiquitous lipid with different biological functions. In blood, there is a close relationship between CoQ status and cholesterol, which strongly supports the study of both molecules simultaneously. The objective of this study was to evaluate plasma CoQ, lipoprotein concentrat...

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Autores: Minguez B, de Los Santos M, Garcia-Volpe C, Molera C, Paredes-Fuentes AJ, Oliva C, Arias A, Rodriguez-Gonzalez H, Yubero D, Tondo M, Santos-Ocaña C, Meavilla S, Artuch R
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p26746
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=26746
Access Level:acceso abierto
Palabra clave:cholesterol
coenzyme Q10
hypercholesterolemia
hypobetalipoproteinemia
paediatric patients
dyslipidaemia
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spelling Exploring Plasma Coenzyme Q10 Status in Paediatric DyslipidaemiaMinguez Bde Los Santos MGarcia-Volpe CMolera CParedes-Fuentes AJOliva CArias ARodriguez-Gonzalez HYubero DTondo MSantos-Ocaña CMeavilla SArtuch Rcholesterolcoenzyme Q10hypercholesterolemiahypobetalipoproteinemiapaediatric patientsdyslipidaemiaCoenzyme Q10 (CoQ) is a ubiquitous lipid with different biological functions. In blood, there is a close relationship between CoQ status and cholesterol, which strongly supports the study of both molecules simultaneously. The objective of this study was to evaluate plasma CoQ, lipoprotein concentrations and CoQ/Chol ratio in a cohort of paediatric patients with different types of dyslipidaemias. A total of 60 paediatric patients were recruited (age range: 7 months-18 years), including 52 with different types of hypercholesterolemia, 2 with isolated hypertriglyceridemia and 6 with hypobetalipoproteinemia. Plasma CoQ was analysed by HPLC with electrochemical detection, and lipoprotein and cholesterol concentrations by standard automated methods. The lowest CoQ values were detected in patients with hypobetalipoproteinemia and in two cases of liver cirrhosis. Mean CoQ values were significantly higher in hypercholesterolemic patients compared to controls (average values 1.07 mu mol/L and 0.63 mu mol/L) while the CoQ/cholesterol ratio did not show differences (170 vs. 163, respectively). Mean CoQ values were significantly lower in the group of patients with hypobetalipoproteinemia compared to controls (mean CoQ values of 0.22 mu mol/L vs. 0.63 mu mol/L, respectively), while those of CoQ/cholesterol did not show differences. Pearson's correlation test showed a positive correlation between the CoQ and cholesterol values (r = 0.565, p < 0.001) and between the CoQ and the LDL cholesterol values (r = 0.610, p < 0.001). Our results suggest that it is advisable to analyse plasma CoQ and cholesterol concentrations in patients with hypobetalipoproteinemia and hypercholesterolemia associated with liver damage.MDPI2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=26746AntioxidantsISSN: 20763921reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p267462026-05-27T12:37:41Z
dc.title.none.fl_str_mv Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
title Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
spellingShingle Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
Minguez B
cholesterol
coenzyme Q10
hypercholesterolemia
hypobetalipoproteinemia
paediatric patients
dyslipidaemia
title_short Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
title_full Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
title_fullStr Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
title_full_unstemmed Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
title_sort Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
dc.creator.none.fl_str_mv Minguez B
de Los Santos M
Garcia-Volpe C
Molera C
Paredes-Fuentes AJ
Oliva C
Arias A
Rodriguez-Gonzalez H
Yubero D
Tondo M
Santos-Ocaña C
Meavilla S
Artuch R
author Minguez B
author_facet Minguez B
de Los Santos M
Garcia-Volpe C
Molera C
Paredes-Fuentes AJ
Oliva C
Arias A
Rodriguez-Gonzalez H
Yubero D
Tondo M
Santos-Ocaña C
Meavilla S
Artuch R
author_role author
author2 de Los Santos M
Garcia-Volpe C
Molera C
Paredes-Fuentes AJ
Oliva C
Arias A
Rodriguez-Gonzalez H
Yubero D
Tondo M
Santos-Ocaña C
Meavilla S
Artuch R
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv cholesterol
coenzyme Q10
hypercholesterolemia
hypobetalipoproteinemia
paediatric patients
dyslipidaemia
topic cholesterol
coenzyme Q10
hypercholesterolemia
hypobetalipoproteinemia
paediatric patients
dyslipidaemia
description Coenzyme Q10 (CoQ) is a ubiquitous lipid with different biological functions. In blood, there is a close relationship between CoQ status and cholesterol, which strongly supports the study of both molecules simultaneously. The objective of this study was to evaluate plasma CoQ, lipoprotein concentrations and CoQ/Chol ratio in a cohort of paediatric patients with different types of dyslipidaemias. A total of 60 paediatric patients were recruited (age range: 7 months-18 years), including 52 with different types of hypercholesterolemia, 2 with isolated hypertriglyceridemia and 6 with hypobetalipoproteinemia. Plasma CoQ was analysed by HPLC with electrochemical detection, and lipoprotein and cholesterol concentrations by standard automated methods. The lowest CoQ values were detected in patients with hypobetalipoproteinemia and in two cases of liver cirrhosis. Mean CoQ values were significantly higher in hypercholesterolemic patients compared to controls (average values 1.07 mu mol/L and 0.63 mu mol/L) while the CoQ/cholesterol ratio did not show differences (170 vs. 163, respectively). Mean CoQ values were significantly lower in the group of patients with hypobetalipoproteinemia compared to controls (mean CoQ values of 0.22 mu mol/L vs. 0.63 mu mol/L, respectively), while those of CoQ/cholesterol did not show differences. Pearson's correlation test showed a positive correlation between the CoQ and cholesterol values (r = 0.565, p < 0.001) and between the CoQ and the LDL cholesterol values (r = 0.610, p < 0.001). Our results suggest that it is advisable to analyse plasma CoQ and cholesterol concentrations in patients with hypobetalipoproteinemia and hypercholesterolemia associated with liver damage.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=26746
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=26746
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Antioxidants
ISSN: 20763921
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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