Curcumin and resveratrol improve muscle function and structure through attenuation of proteolytic markers in experimental cancer-induced cachexia

Muscle wasting and cachexia are prominent comorbidities in cancer. Treatment with polyphenolic compounds may partly revert muscle wasting. We hypothesized that treatment with curcumin or resveratrol in cancer cachectic mice may improve muscle phenotype and total body weight through attenuation of se...

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Autores: Penedo Vázquez, Antonio, Durán, Xavier, Mateu de Antonio, Francisco Javier, López Postigo, Adrián, Barreiro Portela, Esther
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/53645
Acceso en línea:http://hdl.handle.net/10230/53645
http://dx.doi.org/10.3390/molecules26164904
Access Level:acceso abierto
Palabra clave:Atrophy signaling pathways
Cancer-induced cachexia mouse model
Curcumin
Muscle function and structure
Muscle proteolysis
Resveratrol
Sirtuin-1
Troponin I
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spelling Curcumin and resveratrol improve muscle function and structure through attenuation of proteolytic markers in experimental cancer-induced cachexiaPenedo Vázquez, AntonioDurán, XavierMateu de Antonio, Francisco JavierLópez Postigo, AdriánBarreiro Portela, EstherAtrophy signaling pathwaysCancer-induced cachexia mouse modelCurcuminMuscle function and structureMuscle proteolysisResveratrolSirtuin-1Troponin IMuscle wasting and cachexia are prominent comorbidities in cancer. Treatment with polyphenolic compounds may partly revert muscle wasting. We hypothesized that treatment with curcumin or resveratrol in cancer cachectic mice may improve muscle phenotype and total body weight through attenuation of several proteolytic and signaling mechanisms in limb muscles. In gastrocnemius and soleus muscles of cancer cachectic mice (LP07 adenocarcinoma cells, N = 10/group): (1) LC-induced cachexia, (2) LC-cachexia+curcumin, and (3) LC-cachexia + resveratrol, muscle structure and damage (including blood troponin I), sirtuin-1, proteolytic markers, and signaling pathways (NF-κB and FoxO3) were explored (immunohistochemistry and immunoblotting). Compared to nontreated cachectic mice, in LC-cachexia + curcumin and LC-cachexia + resveratrol groups, body and muscle weights (gastrocnemius), limb muscle strength, muscle damage, and myofiber cross-sectional area improved, and in both muscles, sirtuin-1 increased, while proteolysis (troponin I), proteolytic markers, and signaling pathways were attenuated. Curcumin and resveratrol elicited beneficial effects on fast- and slow-twitch limb muscle phenotypes in cachectic mice through sirtuin-1 activation, attenuation of atrophy signaling pathways, and proteolysis in cancer cachectic mice. These findings have future therapeutic implications as these natural compounds, separately or in combination, may be used in clinical settings of muscle mass loss and dysfunction including cancer cachexia.MDPI202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53645http://dx.doi.org/10.3390/molecules26164904reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/536452026-06-12T07:21:37Z
dc.title.none.fl_str_mv Curcumin and resveratrol improve muscle function and structure through attenuation of proteolytic markers in experimental cancer-induced cachexia
title Curcumin and resveratrol improve muscle function and structure through attenuation of proteolytic markers in experimental cancer-induced cachexia
spellingShingle Curcumin and resveratrol improve muscle function and structure through attenuation of proteolytic markers in experimental cancer-induced cachexia
Penedo Vázquez, Antonio
Atrophy signaling pathways
Cancer-induced cachexia mouse model
Curcumin
Muscle function and structure
Muscle proteolysis
Resveratrol
Sirtuin-1
Troponin I
title_short Curcumin and resveratrol improve muscle function and structure through attenuation of proteolytic markers in experimental cancer-induced cachexia
title_full Curcumin and resveratrol improve muscle function and structure through attenuation of proteolytic markers in experimental cancer-induced cachexia
title_fullStr Curcumin and resveratrol improve muscle function and structure through attenuation of proteolytic markers in experimental cancer-induced cachexia
title_full_unstemmed Curcumin and resveratrol improve muscle function and structure through attenuation of proteolytic markers in experimental cancer-induced cachexia
title_sort Curcumin and resveratrol improve muscle function and structure through attenuation of proteolytic markers in experimental cancer-induced cachexia
dc.creator.none.fl_str_mv Penedo Vázquez, Antonio
Durán, Xavier
Mateu de Antonio, Francisco Javier
López Postigo, Adrián
Barreiro Portela, Esther
author Penedo Vázquez, Antonio
author_facet Penedo Vázquez, Antonio
Durán, Xavier
Mateu de Antonio, Francisco Javier
López Postigo, Adrián
Barreiro Portela, Esther
author_role author
author2 Durán, Xavier
Mateu de Antonio, Francisco Javier
López Postigo, Adrián
Barreiro Portela, Esther
author2_role author
author
author
author
dc.subject.none.fl_str_mv Atrophy signaling pathways
Cancer-induced cachexia mouse model
Curcumin
Muscle function and structure
Muscle proteolysis
Resveratrol
Sirtuin-1
Troponin I
topic Atrophy signaling pathways
Cancer-induced cachexia mouse model
Curcumin
Muscle function and structure
Muscle proteolysis
Resveratrol
Sirtuin-1
Troponin I
description Muscle wasting and cachexia are prominent comorbidities in cancer. Treatment with polyphenolic compounds may partly revert muscle wasting. We hypothesized that treatment with curcumin or resveratrol in cancer cachectic mice may improve muscle phenotype and total body weight through attenuation of several proteolytic and signaling mechanisms in limb muscles. In gastrocnemius and soleus muscles of cancer cachectic mice (LP07 adenocarcinoma cells, N = 10/group): (1) LC-induced cachexia, (2) LC-cachexia+curcumin, and (3) LC-cachexia + resveratrol, muscle structure and damage (including blood troponin I), sirtuin-1, proteolytic markers, and signaling pathways (NF-κB and FoxO3) were explored (immunohistochemistry and immunoblotting). Compared to nontreated cachectic mice, in LC-cachexia + curcumin and LC-cachexia + resveratrol groups, body and muscle weights (gastrocnemius), limb muscle strength, muscle damage, and myofiber cross-sectional area improved, and in both muscles, sirtuin-1 increased, while proteolysis (troponin I), proteolytic markers, and signaling pathways were attenuated. Curcumin and resveratrol elicited beneficial effects on fast- and slow-twitch limb muscle phenotypes in cachectic mice through sirtuin-1 activation, attenuation of atrophy signaling pathways, and proteolysis in cancer cachectic mice. These findings have future therapeutic implications as these natural compounds, separately or in combination, may be used in clinical settings of muscle mass loss and dysfunction including cancer cachexia.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/53645
http://dx.doi.org/10.3390/molecules26164904
url http://hdl.handle.net/10230/53645
http://dx.doi.org/10.3390/molecules26164904
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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