Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy

To detect hyper-conserved regions in the hepatitis B virus (HBV) X gene (HBX) 5' region that could be candidates for gene therapy. The study included 27 chronic hepatitis B treatment-naive patients in various clinical stages (from chronic infection to cirrhosis and hepatocellular carcinoma, bot...

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Detalles Bibliográficos
Autores: González, Carolina|||0000-0002-0169-5874, Tabernero, David|||0000-0002-1146-4084, Cortese, Maria Francesca|||0000-0002-4318-532X, Gregori i Font, Josep|||0000-0002-4253-8015, Casillas, Rosario|||0000-0002-6758-6734, Riveiro Barciela, Mar|||0000-0001-9309-2052, Godoy, Cristina|||0000-0001-5037-1916, Sopena, Sara|||0000-0002-3309-5486, Rando-Segura, Ariadna|||0000-0003-4555-7286, Yll, Marçal|||0000-0002-7030-3360, Lopez Martinez, Rosa|||0000-0002-8450-6986, Quer, Josep|||0000-0003-0014-084X, Esteban, Rafael|||0000-0001-5280-392X, Buti, Maria|||0000-0002-0732-3078, Rodríguez Frías, Francisco|||0000-0002-9128-7013
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:195067
Acceso en línea:https://ddd.uab.cat/record/195067
https://dx.doi.org/urn:doi:10.3748/wjg.v24.i19.2095
Access Level:acceso abierto
Palabra clave:Hepatitis B virus
Hepatitis B X gene
Hepatitis B X protein
Gene therapy
Next-generation sequencing
HBV conserved regions
Small interference RNA
Descripción
Sumario:To detect hyper-conserved regions in the hepatitis B virus (HBV) X gene (HBX) 5' region that could be candidates for gene therapy. The study included 27 chronic hepatitis B treatment-naive patients in various clinical stages (from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeAg-negative and HBeAg-positive), and infected with HBV genotypes A-F and H. In a serum sample from each patient with viremia.

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