Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate

The rheological properties of blood depend highly on the properties of its red blood cells: concentration, membrane elasticity, and aggregation. These properties affect the viscosity of blood as well as its shear thinning behavior. Using an experimental analysis of the interface advancement of blood...

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Detalles Bibliográficos
Autores: Trejo-Soto, C., Hernández-Machado, A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2072/531793
Acceso en línea:http://hdl.handle.net/2072/531793
Access Level:acceso abierto
Palabra clave:Blood
Hematocrit
Microfluidics
Shear rate
Viscosity
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spelling Normalization of Blood Viscosity According to the Hematocrit and the Shear RateTrejo-Soto, C.Hernández-Machado, A.BloodHematocritMicrofluidicsShear rateViscosityThe rheological properties of blood depend highly on the properties of its red blood cells: concentration, membrane elasticity, and aggregation. These properties affect the viscosity of blood as well as its shear thinning behavior. Using an experimental analysis of the interface advancement of blood in a microchannel, we determine the viscosity of different samples of blood. In this work, we present two methods that successfully normalize the viscosity of blood for a single and for different donors, first according to the concentration of erythrocytes and second according to the shear rate. The proposed methodology is able to predict the health conditions of the blood samples by introducing a non-dimensional coefficient that accounts for the response to shear rate of the different donors blood samples. By means of these normalization methods, we were able to determine the differences between the red blood cells of the samples and define a range where healthy blood samples can be described by a single behavior. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.PID2019-106063GB-100; Precast/Prestressed Concrete Institute, PCI: DI039.343/2021, DIII039.425/2020, MEC80180021. This work also acknowledges the CERCA Programme of the Generalitat de Catalunya for institutional support. This work was also supported by the Spanish State Research Agency, through the Severo Ochoa and Maria de Maeztu Program for Centres and Units of Excellence in R&D (CEX2020-001084-M).MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion20 p.application/pdfhttp://hdl.handle.net/2072/531793RECERCAT (Dipòsit de la Recerca de Catalunya)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésMicromachinesL'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2072/5317932026-05-29T05:05:01Z
dc.title.none.fl_str_mv Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate
title Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate
spellingShingle Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate
Trejo-Soto, C.
Blood
Hematocrit
Microfluidics
Shear rate
Viscosity
title_short Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate
title_full Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate
title_fullStr Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate
title_full_unstemmed Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate
title_sort Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate
dc.creator.none.fl_str_mv Trejo-Soto, C.
Hernández-Machado, A.
author Trejo-Soto, C.
author_facet Trejo-Soto, C.
Hernández-Machado, A.
author_role author
author2 Hernández-Machado, A.
author2_role author
dc.subject.none.fl_str_mv Blood
Hematocrit
Microfluidics
Shear rate
Viscosity
topic Blood
Hematocrit
Microfluidics
Shear rate
Viscosity
description The rheological properties of blood depend highly on the properties of its red blood cells: concentration, membrane elasticity, and aggregation. These properties affect the viscosity of blood as well as its shear thinning behavior. Using an experimental analysis of the interface advancement of blood in a microchannel, we determine the viscosity of different samples of blood. In this work, we present two methods that successfully normalize the viscosity of blood for a single and for different donors, first according to the concentration of erythrocytes and second according to the shear rate. The proposed methodology is able to predict the health conditions of the blood samples by introducing a non-dimensional coefficient that accounts for the response to shear rate of the different donors blood samples. By means of these normalization methods, we were able to determine the differences between the red blood cells of the samples and define a range where healthy blood samples can be described by a single behavior. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/2072/531793
url http://hdl.handle.net/2072/531793
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Micromachines
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 20 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv RECERCAT (Dipòsit de la Recerca de Catalunya)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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