Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets

Sørensen, T.I.A (Thorkild I. A.)|||/items/be862a34-8bb8-4755-ac24-3ed3689e43d0; Boutin, P. (Philippe)|||/items/c0389ed7-b2a7-426d-9acc-17b2d5de7412; Taylor, M. (Moira)|||/items/75212ca6-89ed-45c8-a94b-02721c243342; Larsen, L.H. (Lesli H.)|||/items/058e94ff-9ffb-45a1-8833-1fd8522ac4e5; Verdich, C. (Camilla)|||/items/71979b15-057d-4c88-afa2-e37a7b25c042; Petersen, L. (Liselotte)|||/items/1255eff7-62cf-4477-ade4-9295cc365767; Holst, C. (C.)|||/items/d9318459-9342-49cf-a2da-d6aeb6914a12; Echwald, S.M. (S.M.)|||/items/275a3913-4c56-44b9-beeb-2aaa75ec67c2; Dina, C. (Christian)|||/items/fbbd25c1-2f41-4f77-9afd-9d99e59a4397; Toubro, S. (Soren)|||/items/4e6da0f4-7920-4fde-8bc8-7c497715c802; Petersen, M. (Martin)|||/items/b697a0f9-f639-408e-b02d-945bdb4ddbed; Polak, J. (Jan)|||/items/6012ab25-ff62-41b9-8d82-480d012fb1e8; Clement, K. (K.)|||/items/a1ac3fde-f54a-4583-9038-b98b42f75ab2; Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131; Langin, D. (D.)|||/items/a17c9463-bbbd-46f0-b728-88e7ae1c8c81; Oppert, J.M. (Jean M.)|||/items/93cbce83-69c1-4820-9e4b-a4003c9c5629; Stich, V. (Vladimir)|||/items/12cd7312-8def-482b-aa73-1324f82cff2b; MacDonald, I. (Ian)|||/items/c1052005-3adc-4628-8276-f2803549627f; Arner, P. (P.)|||/items/c11ace02-ca13-47f1-9e11-8d68ca70ac3b; Saris, W.H.M. (Wim H. M.)|||/items/72a768f2-c225-4139-86ea-e7895ef2a736; Pedersen, O. (Oluf)|||/items/7f57f180-6e9b-44fd-914e-e2f48b9c94e7; Astrup, A. (Arne)|||/items/f6a0e5d3-b236-40b9-a5a3-c380ae3446f2; Froguel, P. (Philippe)|||/items/9e9758d5-6b99-406b-ad31-e7eb687e1721

Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets

OBJECTIVES: To study if genes with common single nucleotide polymorphisms (SNPs) associated with obesity-related phenotypes influence weight loss (WL) in obese individuals treated by a hypo-energetic low-fat or high-fat diet. DESIGN: Randomised, parallel, two-arm, open-label multi-centre trial. SETT...

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Detalles Bibliográficos
Autores:	Sørensen, T.I.A (Thorkild I. A.)\|\|\|/items/be862a34-8bb8-4755-ac24-3ed3689e43d0, Boutin, P. (Philippe)\|\|\|/items/c0389ed7-b2a7-426d-9acc-17b2d5de7412, Taylor, M. (Moira)\|\|\|/items/75212ca6-89ed-45c8-a94b-02721c243342, Larsen, L.H. (Lesli H.)\|\|\|/items/058e94ff-9ffb-45a1-8833-1fd8522ac4e5, Verdich, C. (Camilla)\|\|\|/items/71979b15-057d-4c88-afa2-e37a7b25c042, Petersen, L. (Liselotte)\|\|\|/items/1255eff7-62cf-4477-ade4-9295cc365767, Holst, C. (C.)\|\|\|/items/d9318459-9342-49cf-a2da-d6aeb6914a12, Echwald, S.M. (S.M.)\|\|\|/items/275a3913-4c56-44b9-beeb-2aaa75ec67c2, Dina, C. (Christian)\|\|\|/items/fbbd25c1-2f41-4f77-9afd-9d99e59a4397, Toubro, S. (Soren)\|\|\|/items/4e6da0f4-7920-4fde-8bc8-7c497715c802, Petersen, M. (Martin)\|\|\|/items/b697a0f9-f639-408e-b02d-945bdb4ddbed, Polak, J. (Jan)\|\|\|/items/6012ab25-ff62-41b9-8d82-480d012fb1e8, Clement, K. (K.)\|\|\|/items/a1ac3fde-f54a-4583-9038-b98b42f75ab2, Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131, Langin, D. (D.)\|\|\|/items/a17c9463-bbbd-46f0-b728-88e7ae1c8c81, Oppert, J.M. (Jean M.)\|\|\|/items/93cbce83-69c1-4820-9e4b-a4003c9c5629, Stich, V. (Vladimir)\|\|\|/items/12cd7312-8def-482b-aa73-1324f82cff2b, MacDonald, I. (Ian)\|\|\|/items/c1052005-3adc-4628-8276-f2803549627f, Arner, P. (P.)\|\|\|/items/c11ace02-ca13-47f1-9e11-8d68ca70ac3b, Saris, W.H.M. (Wim H. M.)\|\|\|/items/72a768f2-c225-4139-86ea-e7895ef2a736, Pedersen, O. (Oluf)\|\|\|/items/7f57f180-6e9b-44fd-914e-e2f48b9c94e7, Astrup, A. (Arne)\|\|\|/items/f6a0e5d3-b236-40b9-a5a3-c380ae3446f2, Froguel, P. (Philippe)\|\|\|/items/9e9758d5-6b99-406b-ad31-e7eb687e1721
Tipo de recurso:	artículo
Fecha de publicación:	2006
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/28176
Acceso en línea:	https://hdl.handle.net/10171/28176
Access Level:	acceso abierto
Palabra clave:	Genetic polymorphisms Weight loss Obesity Low fat diet Genotype environment interaction

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spelling	Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat dietsSørensen, T.I.A (Thorkild I. A.)\|\|\|/items/be862a34-8bb8-4755-ac24-3ed3689e43d0Boutin, P. (Philippe)\|\|\|/items/c0389ed7-b2a7-426d-9acc-17b2d5de7412Taylor, M. (Moira)\|\|\|/items/75212ca6-89ed-45c8-a94b-02721c243342Larsen, L.H. (Lesli H.)\|\|\|/items/058e94ff-9ffb-45a1-8833-1fd8522ac4e5Verdich, C. (Camilla)\|\|\|/items/71979b15-057d-4c88-afa2-e37a7b25c042Petersen, L. (Liselotte)\|\|\|/items/1255eff7-62cf-4477-ade4-9295cc365767Holst, C. (C.)\|\|\|/items/d9318459-9342-49cf-a2da-d6aeb6914a12Echwald, S.M. (S.M.)\|\|\|/items/275a3913-4c56-44b9-beeb-2aaa75ec67c2Dina, C. (Christian)\|\|\|/items/fbbd25c1-2f41-4f77-9afd-9d99e59a4397Toubro, S. (Soren)\|\|\|/items/4e6da0f4-7920-4fde-8bc8-7c497715c802Petersen, M. (Martin)\|\|\|/items/b697a0f9-f639-408e-b02d-945bdb4ddbedPolak, J. (Jan)\|\|\|/items/6012ab25-ff62-41b9-8d82-480d012fb1e8Clement, K. (K.)\|\|\|/items/a1ac3fde-f54a-4583-9038-b98b42f75ab2Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131Langin, D. (D.)\|\|\|/items/a17c9463-bbbd-46f0-b728-88e7ae1c8c81Oppert, J.M. (Jean M.)\|\|\|/items/93cbce83-69c1-4820-9e4b-a4003c9c5629Stich, V. (Vladimir)\|\|\|/items/12cd7312-8def-482b-aa73-1324f82cff2bMacDonald, I. (Ian)\|\|\|/items/c1052005-3adc-4628-8276-f2803549627fArner, P. (P.)\|\|\|/items/c11ace02-ca13-47f1-9e11-8d68ca70ac3bSaris, W.H.M. (Wim H. M.)\|\|\|/items/72a768f2-c225-4139-86ea-e7895ef2a736Pedersen, O. (Oluf)\|\|\|/items/7f57f180-6e9b-44fd-914e-e2f48b9c94e7Astrup, A. (Arne)\|\|\|/items/f6a0e5d3-b236-40b9-a5a3-c380ae3446f2Froguel, P. (Philippe)\|\|\|/items/9e9758d5-6b99-406b-ad31-e7eb687e1721Genetic polymorphismsWeight lossObesityLow fat dietGenotype environment interactionOBJECTIVES: To study if genes with common single nucleotide polymorphisms (SNPs) associated with obesity-related phenotypes influence weight loss (WL) in obese individuals treated by a hypo-energetic low-fat or high-fat diet. DESIGN: Randomised, parallel, two-arm, open-label multi-centre trial. SETTING: Eight clinical centres in seven European countries. PARTICIPANTS: 771 obese adult individuals. INTERVENTIONS: 10-wk dietary intervention to hypo-energetic (-600 kcal/d) diets with a targeted fat energy of 20%-25% or 40%-45%, completed in 648 participants. OUTCOME MEASURES: WL during the 10 wk in relation to genotypes of 42 SNPs in 26 candidate genes, probably associated with hypothalamic regulation of appetite, efficiency of energy expenditure, regulation of adipocyte differentiation and function, lipid and glucose metabolism, or production of adipocytokines, determined in 642 participants. RESULTS: Compared with the noncarriers of each of the SNPs, and after adjusting for gender, age, baseline weight and centre, heterozygotes showed WL differences that ranged from -0.6 to 0.8 kg, and homozygotes, from -0.7 to 3.1 kg. Genotype-dependent additional WL on low-fat diet ranged from 1.9 to -1.6 kg in heterozygotes, and from 3.8 kg to -2.1 kg in homozygotes relative to the noncarriers. Considering the multiple testing conducted, none of the associations was statistically significant. CONCLUSIONS: Polymorphisms in a panel of obesity-related candidate genes play a minor role, if any, in modulating weight changes induced by a moderate hypo-energetic low-fat or high-fat diet.Public Library of SciencesDadun. Depósito Académico Digital Universidad de Navarra20132013-03-2520062006-01-0120062006-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/28176reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/281762026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets
title	Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets
spellingShingle	Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets Sørensen, T.I.A (Thorkild I. A.)\|\|\|/items/be862a34-8bb8-4755-ac24-3ed3689e43d0 Genetic polymorphisms Weight loss Obesity Low fat diet Genotype environment interaction
title_short	Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets
title_full	Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets
title_fullStr	Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets
title_full_unstemmed	Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets
title_sort	Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets
dc.creator.none.fl_str_mv	Sørensen, T.I.A (Thorkild I. A.)\|\|\|/items/be862a34-8bb8-4755-ac24-3ed3689e43d0 Boutin, P. (Philippe)\|\|\|/items/c0389ed7-b2a7-426d-9acc-17b2d5de7412 Taylor, M. (Moira)\|\|\|/items/75212ca6-89ed-45c8-a94b-02721c243342 Larsen, L.H. (Lesli H.)\|\|\|/items/058e94ff-9ffb-45a1-8833-1fd8522ac4e5 Verdich, C. (Camilla)\|\|\|/items/71979b15-057d-4c88-afa2-e37a7b25c042 Petersen, L. (Liselotte)\|\|\|/items/1255eff7-62cf-4477-ade4-9295cc365767 Holst, C. (C.)\|\|\|/items/d9318459-9342-49cf-a2da-d6aeb6914a12 Echwald, S.M. (S.M.)\|\|\|/items/275a3913-4c56-44b9-beeb-2aaa75ec67c2 Dina, C. (Christian)\|\|\|/items/fbbd25c1-2f41-4f77-9afd-9d99e59a4397 Toubro, S. (Soren)\|\|\|/items/4e6da0f4-7920-4fde-8bc8-7c497715c802 Petersen, M. (Martin)\|\|\|/items/b697a0f9-f639-408e-b02d-945bdb4ddbed Polak, J. (Jan)\|\|\|/items/6012ab25-ff62-41b9-8d82-480d012fb1e8 Clement, K. (K.)\|\|\|/items/a1ac3fde-f54a-4583-9038-b98b42f75ab2 Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131 Langin, D. (D.)\|\|\|/items/a17c9463-bbbd-46f0-b728-88e7ae1c8c81 Oppert, J.M. (Jean M.)\|\|\|/items/93cbce83-69c1-4820-9e4b-a4003c9c5629 Stich, V. (Vladimir)\|\|\|/items/12cd7312-8def-482b-aa73-1324f82cff2b MacDonald, I. (Ian)\|\|\|/items/c1052005-3adc-4628-8276-f2803549627f Arner, P. (P.)\|\|\|/items/c11ace02-ca13-47f1-9e11-8d68ca70ac3b Saris, W.H.M. (Wim H. M.)\|\|\|/items/72a768f2-c225-4139-86ea-e7895ef2a736 Pedersen, O. (Oluf)\|\|\|/items/7f57f180-6e9b-44fd-914e-e2f48b9c94e7 Astrup, A. (Arne)\|\|\|/items/f6a0e5d3-b236-40b9-a5a3-c380ae3446f2 Froguel, P. (Philippe)\|\|\|/items/9e9758d5-6b99-406b-ad31-e7eb687e1721
author	Sørensen, T.I.A (Thorkild I. A.)\|\|\|/items/be862a34-8bb8-4755-ac24-3ed3689e43d0
author_facet	Sørensen, T.I.A (Thorkild I. A.)\|\|\|/items/be862a34-8bb8-4755-ac24-3ed3689e43d0 Boutin, P. (Philippe)\|\|\|/items/c0389ed7-b2a7-426d-9acc-17b2d5de7412 Taylor, M. (Moira)\|\|\|/items/75212ca6-89ed-45c8-a94b-02721c243342 Larsen, L.H. (Lesli H.)\|\|\|/items/058e94ff-9ffb-45a1-8833-1fd8522ac4e5 Verdich, C. (Camilla)\|\|\|/items/71979b15-057d-4c88-afa2-e37a7b25c042 Petersen, L. (Liselotte)\|\|\|/items/1255eff7-62cf-4477-ade4-9295cc365767 Holst, C. (C.)\|\|\|/items/d9318459-9342-49cf-a2da-d6aeb6914a12 Echwald, S.M. (S.M.)\|\|\|/items/275a3913-4c56-44b9-beeb-2aaa75ec67c2 Dina, C. (Christian)\|\|\|/items/fbbd25c1-2f41-4f77-9afd-9d99e59a4397 Toubro, S. (Soren)\|\|\|/items/4e6da0f4-7920-4fde-8bc8-7c497715c802 Petersen, M. (Martin)\|\|\|/items/b697a0f9-f639-408e-b02d-945bdb4ddbed Polak, J. (Jan)\|\|\|/items/6012ab25-ff62-41b9-8d82-480d012fb1e8 Clement, K. (K.)\|\|\|/items/a1ac3fde-f54a-4583-9038-b98b42f75ab2 Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131 Langin, D. (D.)\|\|\|/items/a17c9463-bbbd-46f0-b728-88e7ae1c8c81 Oppert, J.M. (Jean M.)\|\|\|/items/93cbce83-69c1-4820-9e4b-a4003c9c5629 Stich, V. (Vladimir)\|\|\|/items/12cd7312-8def-482b-aa73-1324f82cff2b MacDonald, I. (Ian)\|\|\|/items/c1052005-3adc-4628-8276-f2803549627f Arner, P. (P.)\|\|\|/items/c11ace02-ca13-47f1-9e11-8d68ca70ac3b Saris, W.H.M. (Wim H. M.)\|\|\|/items/72a768f2-c225-4139-86ea-e7895ef2a736 Pedersen, O. (Oluf)\|\|\|/items/7f57f180-6e9b-44fd-914e-e2f48b9c94e7 Astrup, A. (Arne)\|\|\|/items/f6a0e5d3-b236-40b9-a5a3-c380ae3446f2 Froguel, P. (Philippe)\|\|\|/items/9e9758d5-6b99-406b-ad31-e7eb687e1721
author_role	author
author2	Boutin, P. (Philippe)\|\|\|/items/c0389ed7-b2a7-426d-9acc-17b2d5de7412 Taylor, M. (Moira)\|\|\|/items/75212ca6-89ed-45c8-a94b-02721c243342 Larsen, L.H. (Lesli H.)\|\|\|/items/058e94ff-9ffb-45a1-8833-1fd8522ac4e5 Verdich, C. (Camilla)\|\|\|/items/71979b15-057d-4c88-afa2-e37a7b25c042 Petersen, L. (Liselotte)\|\|\|/items/1255eff7-62cf-4477-ade4-9295cc365767 Holst, C. (C.)\|\|\|/items/d9318459-9342-49cf-a2da-d6aeb6914a12 Echwald, S.M. (S.M.)\|\|\|/items/275a3913-4c56-44b9-beeb-2aaa75ec67c2 Dina, C. (Christian)\|\|\|/items/fbbd25c1-2f41-4f77-9afd-9d99e59a4397 Toubro, S. (Soren)\|\|\|/items/4e6da0f4-7920-4fde-8bc8-7c497715c802 Petersen, M. (Martin)\|\|\|/items/b697a0f9-f639-408e-b02d-945bdb4ddbed Polak, J. (Jan)\|\|\|/items/6012ab25-ff62-41b9-8d82-480d012fb1e8 Clement, K. (K.)\|\|\|/items/a1ac3fde-f54a-4583-9038-b98b42f75ab2 Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131 Langin, D. (D.)\|\|\|/items/a17c9463-bbbd-46f0-b728-88e7ae1c8c81 Oppert, J.M. (Jean M.)\|\|\|/items/93cbce83-69c1-4820-9e4b-a4003c9c5629 Stich, V. (Vladimir)\|\|\|/items/12cd7312-8def-482b-aa73-1324f82cff2b MacDonald, I. (Ian)\|\|\|/items/c1052005-3adc-4628-8276-f2803549627f Arner, P. (P.)\|\|\|/items/c11ace02-ca13-47f1-9e11-8d68ca70ac3b Saris, W.H.M. (Wim H. M.)\|\|\|/items/72a768f2-c225-4139-86ea-e7895ef2a736 Pedersen, O. (Oluf)\|\|\|/items/7f57f180-6e9b-44fd-914e-e2f48b9c94e7 Astrup, A. (Arne)\|\|\|/items/f6a0e5d3-b236-40b9-a5a3-c380ae3446f2 Froguel, P. (Philippe)\|\|\|/items/9e9758d5-6b99-406b-ad31-e7eb687e1721
author2_role	author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Genetic polymorphisms Weight loss Obesity Low fat diet Genotype environment interaction
topic	Genetic polymorphisms Weight loss Obesity Low fat diet Genotype environment interaction
description	OBJECTIVES: To study if genes with common single nucleotide polymorphisms (SNPs) associated with obesity-related phenotypes influence weight loss (WL) in obese individuals treated by a hypo-energetic low-fat or high-fat diet. DESIGN: Randomised, parallel, two-arm, open-label multi-centre trial. SETTING: Eight clinical centres in seven European countries. PARTICIPANTS: 771 obese adult individuals. INTERVENTIONS: 10-wk dietary intervention to hypo-energetic (-600 kcal/d) diets with a targeted fat energy of 20%-25% or 40%-45%, completed in 648 participants. OUTCOME MEASURES: WL during the 10 wk in relation to genotypes of 42 SNPs in 26 candidate genes, probably associated with hypothalamic regulation of appetite, efficiency of energy expenditure, regulation of adipocyte differentiation and function, lipid and glucose metabolism, or production of adipocytokines, determined in 642 participants. RESULTS: Compared with the noncarriers of each of the SNPs, and after adjusting for gender, age, baseline weight and centre, heterozygotes showed WL differences that ranged from -0.6 to 0.8 kg, and homozygotes, from -0.7 to 3.1 kg. Genotype-dependent additional WL on low-fat diet ranged from 1.9 to -1.6 kg in heterozygotes, and from 3.8 kg to -2.1 kg in homozygotes relative to the noncarriers. Considering the multiple testing conducted, none of the associations was statistically significant. CONCLUSIONS: Polymorphisms in a panel of obesity-related candidate genes play a minor role, if any, in modulating weight changes induced by a moderate hypo-energetic low-fat or high-fat diet.
publishDate	2006
dc.date.none.fl_str_mv	2006 2006-01-01 2006 2006-01-01 2013 2013-03-25
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/28176
url	https://hdl.handle.net/10171/28176
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Public Library of Sciences
publisher.none.fl_str_mv	Public Library of Sciences
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
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Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high-versus low-fat diets

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