Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study.

Data on the prevalence of and factors associated with nontuberculous mycobacteria (NTM) in patients with non-cystic fibrosis (CF) bronchiectasis are limited. Our aim was to determine the prevalence and factors associated with isolation of NTM in this population. We performed a multicenter observatio...

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Authors: Máiz, L, Girón, R, Olveira, C, Vendrell, M, Nieto, R, Martínez-García, M A
Format: article
Publication Date:2016
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17151
Online Access:http://hdl.handle.net/20.500.12105/17151
Access Level:Open access
Keyword:Disease prevalence
Epidemiology
Non-cystic fibrosis bronchiectasis
Nontuberculous mycobacteria
Adult
Age Factors
Aged
Body Mass Index
Bronchiectasis
Cystic Fibrosis
Female
Humans
Male
Middle Aged
Mycobacterium Infections, Nontuberculous
Mycobacterium avium Complex
Nontuberculous Mycobacteria
Odds Ratio
Prevalence
Sputum
Tomography, X-Ray Computed
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spelling Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study.Máiz, LGirón, ROlveira, CVendrell, MNieto, RMartínez-García, M ADisease prevalenceEpidemiologyNon-cystic fibrosis bronchiectasisNontuberculous mycobacteriaAdultAge FactorsAgedBody Mass IndexBronchiectasisCystic FibrosisFemaleHumansMaleMiddle AgedMycobacterium Infections, NontuberculousMycobacterium avium ComplexNontuberculous MycobacteriaOdds RatioPrevalenceSputumTomography, X-Ray ComputedData on the prevalence of and factors associated with nontuberculous mycobacteria (NTM) in patients with non-cystic fibrosis (CF) bronchiectasis are limited. Our aim was to determine the prevalence and factors associated with isolation of NTM in this population. We performed a multicenter observational study of historical cohorts comprising consecutive patients with non-CF bronchiectasis and at least 2 sputum samples cultured for mycobacteria over a period of 5 years. The study population included 218 adult patients (61.9 % women) with a mean (SD) age of 55.7 (16) years and a mean (SD) of 5.1 (3.3) cultures/patient. NTM was isolated from sputum in 18 patients (8.3 %). Of these, 5 patients (28 %) met the American Thoracic Society criteria for NTM disease. Mycobacterium avium complex was the most frequently isolated microorganism (9 patients, 4.1 %). The variables independently associated with isolation of NTM were FVC ≥ 75 % predicted (OR, 4.84; 95 % CI 1.47 to 15.9; p  A significant number of patients with non-CF bronchiectasis are positive for the isolation of NTM. M. avium complex is the most frequently isolated mycobacteria. FVC ≥ 75 % predicted, age ≥ 50 years, and a BMI ≤ 23 kg/m(2) were independently associated with the presence of NTM in patients with non-CF bronchiectasis.20242024-01-1620162016-08-2220162016-08-22research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/17151reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/171512026-06-12T12:43:37Z
dc.title.none.fl_str_mv Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study.
title Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study.
spellingShingle Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study.
Máiz, L
Disease prevalence
Epidemiology
Non-cystic fibrosis bronchiectasis
Nontuberculous mycobacteria
Adult
Age Factors
Aged
Body Mass Index
Bronchiectasis
Cystic Fibrosis
Female
Humans
Male
Middle Aged
Mycobacterium Infections, Nontuberculous
Mycobacterium avium Complex
Nontuberculous Mycobacteria
Odds Ratio
Prevalence
Sputum
Tomography, X-Ray Computed
title_short Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study.
title_full Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study.
title_fullStr Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study.
title_full_unstemmed Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study.
title_sort Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study.
dc.creator.none.fl_str_mv Máiz, L
Girón, R
Olveira, C
Vendrell, M
Nieto, R
Martínez-García, M A
author Máiz, L
author_facet Máiz, L
Girón, R
Olveira, C
Vendrell, M
Nieto, R
Martínez-García, M A
author_role author
author2 Girón, R
Olveira, C
Vendrell, M
Nieto, R
Martínez-García, M A
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Disease prevalence
Epidemiology
Non-cystic fibrosis bronchiectasis
Nontuberculous mycobacteria
Adult
Age Factors
Aged
Body Mass Index
Bronchiectasis
Cystic Fibrosis
Female
Humans
Male
Middle Aged
Mycobacterium Infections, Nontuberculous
Mycobacterium avium Complex
Nontuberculous Mycobacteria
Odds Ratio
Prevalence
Sputum
Tomography, X-Ray Computed
topic Disease prevalence
Epidemiology
Non-cystic fibrosis bronchiectasis
Nontuberculous mycobacteria
Adult
Age Factors
Aged
Body Mass Index
Bronchiectasis
Cystic Fibrosis
Female
Humans
Male
Middle Aged
Mycobacterium Infections, Nontuberculous
Mycobacterium avium Complex
Nontuberculous Mycobacteria
Odds Ratio
Prevalence
Sputum
Tomography, X-Ray Computed
description Data on the prevalence of and factors associated with nontuberculous mycobacteria (NTM) in patients with non-cystic fibrosis (CF) bronchiectasis are limited. Our aim was to determine the prevalence and factors associated with isolation of NTM in this population. We performed a multicenter observational study of historical cohorts comprising consecutive patients with non-CF bronchiectasis and at least 2 sputum samples cultured for mycobacteria over a period of 5 years. The study population included 218 adult patients (61.9 % women) with a mean (SD) age of 55.7 (16) years and a mean (SD) of 5.1 (3.3) cultures/patient. NTM was isolated from sputum in 18 patients (8.3 %). Of these, 5 patients (28 %) met the American Thoracic Society criteria for NTM disease. Mycobacterium avium complex was the most frequently isolated microorganism (9 patients, 4.1 %). The variables independently associated with isolation of NTM were FVC ≥ 75 % predicted (OR, 4.84; 95 % CI 1.47 to 15.9; p  A significant number of patients with non-CF bronchiectasis are positive for the isolation of NTM. M. avium complex is the most frequently isolated mycobacteria. FVC ≥ 75 % predicted, age ≥ 50 years, and a BMI ≤ 23 kg/m(2) were independently associated with the presence of NTM in patients with non-CF bronchiectasis.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-08-22
2016
2016-08-22
2024
2024-01-16
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17151
url http://hdl.handle.net/20.500.12105/17151
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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