Herpesvirus surveillance in stranded striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from Italy with emphasis on neuropathological characterization

Herpesvirus (HV) is widely distributed among cetacean populations, with the highest prevalence reported in the Mediterranean Sea. In this study, a comprehensive analysis was conducted, including epidemiological, phylogenetic, and pathological aspects, with particular emphasis on neuropathology, to b...

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Autores: Vargas Castro, Ignacio, Giorda, Federica, Mattioda, Virginia, Goria, Maria, Serracca, Laura, Varello, Katia, Carta, Valerio, Nodari, Sabrina, Maniaci, Maria Grazia, Dell’Atti, Luana, Testori, Camilla, Pussini, Nicola, Iulini, Barbara, Battistini, Roberta, Zoppi, Simona, Di Nocera, Fabio, Lucifora, Giuseppe, Fontanesi, Elena, Acutis, Pier Luigi, Casalone, Cristina, Grattarola, Carla, Peletto, Simone
Tipo de documento: artigo
Data de publicação:2024
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositório:Docta Complutense
Idioma:inglês
OAI Identifier:oai:docta.ucm.es:20.500.14352/110264
Acesso em linha:https://hdl.handle.net/20.500.14352/110264
Access Level:Acceso aberto
Palavra-chave:636.09
Veterinaria
3109 Ciencias Veterinarias
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spelling Herpesvirus surveillance in stranded striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from Italy with emphasis on neuropathological characterizationVargas Castro, IgnacioGiorda, FedericaMattioda, VirginiaGoria, MariaSerracca, LauraVarello, KatiaCarta, ValerioNodari, SabrinaManiaci, Maria GraziaDell’Atti, LuanaTestori, CamillaPussini, NicolaIulini, BarbaraBattistini, RobertaZoppi, SimonaDi Nocera, FabioLucifora, GiuseppeFontanesi, ElenaAcutis, Pier LuigiCasalone, CristinaGrattarola, CarlaPeletto, Simone636.09Veterinaria3109 Ciencias VeterinariasHerpesvirus (HV) is widely distributed among cetacean populations, with the highest prevalence reported in the Mediterranean Sea. In this study, a comprehensive analysis was conducted, including epidemiological, phylogenetic, and pathological aspects, with particular emphasis on neuropathology, to better understand the impact of HV in these animals. Our results show a higher presence of HV in males compared to females, with males exhibiting a greater number of positive tissues. Additionally, adults were more frequently affected by HV infection than juveniles, with no infections detected in calves or neonates. The affected species were striped (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus). The highest positivity rates were observed in the genital system, cerebrum, and skin tissues. Phylogenetic analysis indicated a higher occurrence of Gammaherpesvirus (GHV) sequences but increased genetic diversity within Alphaherpesvirus (AHV). Key neuropathological features included astro-microgliosis (n = 4) and meningitis with minimal to mild perivascular cuffing (n = 2). The presence of concurrent infections with other pathogens, particularly cetacean morbillivirus (CeMV), underscores the complex nature of infectious diseases in cetaceans. However, the presence of lesions at the Central Nervous System (CNS) with molecular positivity for GHV, excluding the involvement of other potential neurotropic agents, would confirm the potential of this HV subfamily to induce neurological damage. Pathological examination identified lesions in other organs that could potentially be associated with HV, characterized by lymphoid depletion and tissue inflammation. These findings enhance our understanding of HV in odontocetes and highlight the need for ongoing research into the factors driving these infections and their broader implicationsSan Francisco CA: Biblioteca Pública de CienciasTzen-Yuh ChiangUniversidad Complutense de Madrid20242024-10-2320242024-10-23journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/110264reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1102642026-06-02T12:44:21Z
dc.title.none.fl_str_mv Herpesvirus surveillance in stranded striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from Italy with emphasis on neuropathological characterization
title Herpesvirus surveillance in stranded striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from Italy with emphasis on neuropathological characterization
spellingShingle Herpesvirus surveillance in stranded striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from Italy with emphasis on neuropathological characterization
Vargas Castro, Ignacio
636.09
Veterinaria
3109 Ciencias Veterinarias
title_short Herpesvirus surveillance in stranded striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from Italy with emphasis on neuropathological characterization
title_full Herpesvirus surveillance in stranded striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from Italy with emphasis on neuropathological characterization
title_fullStr Herpesvirus surveillance in stranded striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from Italy with emphasis on neuropathological characterization
title_full_unstemmed Herpesvirus surveillance in stranded striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from Italy with emphasis on neuropathological characterization
title_sort Herpesvirus surveillance in stranded striped dolphins (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus) from Italy with emphasis on neuropathological characterization
dc.creator.none.fl_str_mv Vargas Castro, Ignacio
Giorda, Federica
Mattioda, Virginia
Goria, Maria
Serracca, Laura
Varello, Katia
Carta, Valerio
Nodari, Sabrina
Maniaci, Maria Grazia
Dell’Atti, Luana
Testori, Camilla
Pussini, Nicola
Iulini, Barbara
Battistini, Roberta
Zoppi, Simona
Di Nocera, Fabio
Lucifora, Giuseppe
Fontanesi, Elena
Acutis, Pier Luigi
Casalone, Cristina
Grattarola, Carla
Peletto, Simone
author Vargas Castro, Ignacio
author_facet Vargas Castro, Ignacio
Giorda, Federica
Mattioda, Virginia
Goria, Maria
Serracca, Laura
Varello, Katia
Carta, Valerio
Nodari, Sabrina
Maniaci, Maria Grazia
Dell’Atti, Luana
Testori, Camilla
Pussini, Nicola
Iulini, Barbara
Battistini, Roberta
Zoppi, Simona
Di Nocera, Fabio
Lucifora, Giuseppe
Fontanesi, Elena
Acutis, Pier Luigi
Casalone, Cristina
Grattarola, Carla
Peletto, Simone
author_role author
author2 Giorda, Federica
Mattioda, Virginia
Goria, Maria
Serracca, Laura
Varello, Katia
Carta, Valerio
Nodari, Sabrina
Maniaci, Maria Grazia
Dell’Atti, Luana
Testori, Camilla
Pussini, Nicola
Iulini, Barbara
Battistini, Roberta
Zoppi, Simona
Di Nocera, Fabio
Lucifora, Giuseppe
Fontanesi, Elena
Acutis, Pier Luigi
Casalone, Cristina
Grattarola, Carla
Peletto, Simone
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Tzen-Yuh Chiang
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 636.09
Veterinaria
3109 Ciencias Veterinarias
topic 636.09
Veterinaria
3109 Ciencias Veterinarias
description Herpesvirus (HV) is widely distributed among cetacean populations, with the highest prevalence reported in the Mediterranean Sea. In this study, a comprehensive analysis was conducted, including epidemiological, phylogenetic, and pathological aspects, with particular emphasis on neuropathology, to better understand the impact of HV in these animals. Our results show a higher presence of HV in males compared to females, with males exhibiting a greater number of positive tissues. Additionally, adults were more frequently affected by HV infection than juveniles, with no infections detected in calves or neonates. The affected species were striped (Stenella coeruleoalba) and bottlenose dolphins (Tursiops truncatus). The highest positivity rates were observed in the genital system, cerebrum, and skin tissues. Phylogenetic analysis indicated a higher occurrence of Gammaherpesvirus (GHV) sequences but increased genetic diversity within Alphaherpesvirus (AHV). Key neuropathological features included astro-microgliosis (n = 4) and meningitis with minimal to mild perivascular cuffing (n = 2). The presence of concurrent infections with other pathogens, particularly cetacean morbillivirus (CeMV), underscores the complex nature of infectious diseases in cetaceans. However, the presence of lesions at the Central Nervous System (CNS) with molecular positivity for GHV, excluding the involvement of other potential neurotropic agents, would confirm the potential of this HV subfamily to induce neurological damage. Pathological examination identified lesions in other organs that could potentially be associated with HV, characterized by lymphoid depletion and tissue inflammation. These findings enhance our understanding of HV in odontocetes and highlight the need for ongoing research into the factors driving these infections and their broader implications
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-10-23
2024
2024-10-23
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/110264
url https://hdl.handle.net/20.500.14352/110264
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv San Francisco CA: Biblioteca Pública de Ciencias
publisher.none.fl_str_mv San Francisco CA: Biblioteca Pública de Ciencias
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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