Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical Applications

© 2023 The Authors. Macromolecular Materials and Engineering published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Detalles Bibliográficos
Autores: Sánchez-Cid, Pablo, González-Ulloa, Gabriel, Alonso-González, María, Jiménez-Rosado, Mercedes, Rafii-El-Idrissi Benhnia, Mohamed, Romero, Alberto, Ostos, Francisco José, Pérez-Puyana, Víctor
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::934ef603b8a15d23ec9b1977f344cc3f
Acceso en línea:http://hdl.handle.net/10261/351170
Access Level:acceso abierto
Palabra clave:Biocompatibility
Biomedicine
Chemical crosslinking
Chitosan
D-fructose
Genipin
Hydrogels
Natural crosslinking agents
Rheology
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spelling Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical ApplicationsSánchez-Cid, PabloGonzález-Ulloa, GabrielAlonso-González, MaríaJiménez-Rosado, MercedesRafii-El-Idrissi Benhnia, MohamedRomero, AlbertoOstos, Francisco JoséPérez-Puyana, VíctorBiocompatibilityBiomedicineChemical crosslinkingChitosanD-fructoseGenipinHydrogelsNatural crosslinking agentsRheology© 2023 The Authors. Macromolecular Materials and Engineering published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Chitosan (CH) is a very well-known biopolymer that has been widely used for the development of biomaterials with a wide range of applications in the biomedical field, such as the preparation of hydrogels, owing to its outstanding anti-inflammatory, antibacterial and antifungal properties, biocompatibility and biodegradability, although they present limited mechanical properties. Chemical crosslinking is one of the most recurrent strategies for the reinforcement of these structures and, above all, crosslinking with natural-origin compounds that do not compromise their biocompatibility is considered a hot topic in this research field. D-fructose (F), obtained from the hydrolyzation and further isomerization of starch, an abundant raw material and genipin (G), which is extracted from the fruits of Gardenia jasminoides Ellis are used as natural crosslinkers. Chitosan-based hydrogels crosslinked with each crosslinking agent are prepared and characterized through Fourier transform infrared (FTIR) spectroscopy, crosslinking and swelling degree determination, rheological, microstructural, and biological studies. The results demonstrate that crosslinking with G is more beneficial for chitosan-based hydrogels since these samples showed more compact structures and better rheological performance. Additionally, excellent biological in vitro behavior due to the crosslinking with G, unlike that of F.This study was financially supported by MCIN/AEI/10.13039/501100011033/FEDER, UE, through the project PID2021-124294OB-C21. The authors gratefully acknowledged their financial support. This work was also possible thanks to the postdoctoral contract of Víctor M. Pérez Puyana and Francisco J. Ostos from the “Contratación de Personal Investigador Doctor” supported by the European Social Fund and Junta de Andalucía (PAIDI DOCTOR – Convocatoria 2019–2020, DOC_00586, and DOC_00963).Peer reviewedJohn Wiley & SonsMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Junta de AndalucíaEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/351170reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124294OB-C21https://doi.org/10.1002/mame.202300195Síinfo:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::934ef603b8a15d23ec9b1977f344cc3f2026-05-22T06:33:51Z
dc.title.none.fl_str_mv Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical Applications
title Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical Applications
spellingShingle Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical Applications
Sánchez-Cid, Pablo
Biocompatibility
Biomedicine
Chemical crosslinking
Chitosan
D-fructose
Genipin
Hydrogels
Natural crosslinking agents
Rheology
title_short Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical Applications
title_full Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical Applications
title_fullStr Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical Applications
title_full_unstemmed Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical Applications
title_sort Influence of Natural Crosslinkers on Chitosan Hydrogels for Potential Biomedical Applications
dc.creator.none.fl_str_mv Sánchez-Cid, Pablo
González-Ulloa, Gabriel
Alonso-González, María
Jiménez-Rosado, Mercedes
Rafii-El-Idrissi Benhnia, Mohamed
Romero, Alberto
Ostos, Francisco José
Pérez-Puyana, Víctor
author Sánchez-Cid, Pablo
author_facet Sánchez-Cid, Pablo
González-Ulloa, Gabriel
Alonso-González, María
Jiménez-Rosado, Mercedes
Rafii-El-Idrissi Benhnia, Mohamed
Romero, Alberto
Ostos, Francisco José
Pérez-Puyana, Víctor
author_role author
author2 González-Ulloa, Gabriel
Alonso-González, María
Jiménez-Rosado, Mercedes
Rafii-El-Idrissi Benhnia, Mohamed
Romero, Alberto
Ostos, Francisco José
Pérez-Puyana, Víctor
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Junta de Andalucía
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Biocompatibility
Biomedicine
Chemical crosslinking
Chitosan
D-fructose
Genipin
Hydrogels
Natural crosslinking agents
Rheology
topic Biocompatibility
Biomedicine
Chemical crosslinking
Chitosan
D-fructose
Genipin
Hydrogels
Natural crosslinking agents
Rheology
description © 2023 The Authors. Macromolecular Materials and Engineering published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/351170
url http://hdl.handle.net/10261/351170
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124294OB-C21
https://doi.org/10.1002/mame.202300195
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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