Irisin, two years later

In January 2012, Boström and colleagues identified a new muscle tissue secreted peptide, which they named irisin, to highlight its role as a messenger that comes from skeletal muscle to other parts of the body. Irisin is a cleaved and secreted fragment of FNDC5 (also known as FRCP2 and PeP), a membe...

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Detalles Bibliográficos
Autores: Garrido Novelle, Marta, Contreras Jiménez, Cristina, Romero Picó, Amparo, López, Miguel, Diéguez, Carlos
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/94891
Acceso en línea:https://hdl.handle.net/20.500.14352/94891
Access Level:acceso abierto
Palabra clave:577.17
Farmacología (Medicina)
Medicamentos
2411.04 Fisiología Endocrina
3206.10 Enfermedades de la Nutrición
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repository_id_str
spelling Irisin, two years laterGarrido Novelle, MartaContreras Jiménez, CristinaRomero Picó, AmparoLópez, MiguelDiéguez, Carlos577.17Farmacología (Medicina)Medicamentos2411.04 Fisiología Endocrina3206.10 Enfermedades de la NutriciónIn January 2012, Boström and colleagues identified a new muscle tissue secreted peptide, which they named irisin, to highlight its role as a messenger that comes from skeletal muscle to other parts of the body. Irisin is a cleaved and secreted fragment of FNDC5 (also known as FRCP2 and PeP), a member of fibronectin type III repeat containing gene family. Major interest in this protein arose because of its great therapeutic potential in diabetes and perhaps also therapy for obesity. Here we review the most important aspects of irisin’s action and discuss its involvement in energy and metabolic homeostasis and whether the beneficial effects of exercise in these disease states could be mediated by this protein. In addition the effects of irisin at the central nervous system (CNS) are highlighted. It is concluded that although current and upcoming research on irisin is very promising it is still necessary to deepen in several aspects in order to clarify its full potential as a meaningful drug target in human disease states.WileyUniversidad Complutense de Madrid20132013-01-0120132013-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/94891reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/948912026-06-02T12:44:21Z
dc.title.none.fl_str_mv Irisin, two years later
title Irisin, two years later
spellingShingle Irisin, two years later
Garrido Novelle, Marta
577.17
Farmacología (Medicina)
Medicamentos
2411.04 Fisiología Endocrina
3206.10 Enfermedades de la Nutrición
title_short Irisin, two years later
title_full Irisin, two years later
title_fullStr Irisin, two years later
title_full_unstemmed Irisin, two years later
title_sort Irisin, two years later
dc.creator.none.fl_str_mv Garrido Novelle, Marta
Contreras Jiménez, Cristina
Romero Picó, Amparo
López, Miguel
Diéguez, Carlos
author Garrido Novelle, Marta
author_facet Garrido Novelle, Marta
Contreras Jiménez, Cristina
Romero Picó, Amparo
López, Miguel
Diéguez, Carlos
author_role author
author2 Contreras Jiménez, Cristina
Romero Picó, Amparo
López, Miguel
Diéguez, Carlos
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.17
Farmacología (Medicina)
Medicamentos
2411.04 Fisiología Endocrina
3206.10 Enfermedades de la Nutrición
topic 577.17
Farmacología (Medicina)
Medicamentos
2411.04 Fisiología Endocrina
3206.10 Enfermedades de la Nutrición
description In January 2012, Boström and colleagues identified a new muscle tissue secreted peptide, which they named irisin, to highlight its role as a messenger that comes from skeletal muscle to other parts of the body. Irisin is a cleaved and secreted fragment of FNDC5 (also known as FRCP2 and PeP), a member of fibronectin type III repeat containing gene family. Major interest in this protein arose because of its great therapeutic potential in diabetes and perhaps also therapy for obesity. Here we review the most important aspects of irisin’s action and discuss its involvement in energy and metabolic homeostasis and whether the beneficial effects of exercise in these disease states could be mediated by this protein. In addition the effects of irisin at the central nervous system (CNS) are highlighted. It is concluded that although current and upcoming research on irisin is very promising it is still necessary to deepen in several aspects in order to clarify its full potential as a meaningful drug target in human disease states.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01
2013
2013-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/94891
url https://hdl.handle.net/20.500.14352/94891
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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