Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project

Transcranial magnetic stimulation (TMS) can interfere with cognitive processes, such as transiently impairing memory. As part of a multi-center European project, we investigated the adaptability and reproducibility of a previously published TMS memory interfering protocol in two centers using EEG or...

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Autores: Martin Trias, Pablo, Lanteaume, Laura, Solana, Elisabeth, Cassé Perrot, Catherine, Fernández Cabello, Sara, Babiloni, Claudio, Marzano, Nicola, Junqué i Plaja, Carme, 1955-, Rossini, Paolo Maria, Micallef, Joëlle, Truillet, Romain, Charles, Estelle, Jouve, Elisabeth, Bordet, Régis, Santamaria Cano, Joan, Jovicich, Jorge, Rossi, Simone, Pascual Leone, Álvaro, 1961-, Blin, Olivier, Richardson, Jill, Bartrés Faz, David
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/129426
Acesso em linha:https://hdl.handle.net/2445/129426
Access Level:acceso abierto
Palavra-chave:Escorça cerebral
Neurociència cognitiva
Estimulació del cervell
Cerebral cortex
Cognitive neuroscience
Brain stimulation
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spelling Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European projectMartin Trias, PabloLanteaume, LauraSolana, ElisabethCassé Perrot, CatherineFernández Cabello, SaraBabiloni, ClaudioMarzano, NicolaJunqué i Plaja, Carme, 1955-Rossini, Paolo MariaMicallef, JoëlleTruillet, RomainCharles, EstelleJouve, ElisabethBordet, RégisSantamaria Cano, JoanJovicich, JorgeRossi, SimonePascual Leone, Álvaro, 1961-Blin, OlivierRichardson, JillBartrés Faz, DavidEscorça cerebralNeurociència cognitivaEstimulació del cervellCerebral cortexCognitive neuroscienceBrain stimulationTranscranial magnetic stimulation (TMS) can interfere with cognitive processes, such as transiently impairing memory. As part of a multi-center European project, we investigated the adaptability and reproducibility of a previously published TMS memory interfering protocol in two centers using EEG or fMRI scenarios. Participants were invited to attend three experimental sessions on different days, with sham repetitive TMS (rTMS) applied on day 1 and real rTMS on days 2 and 3. Sixty-eight healthy young men were included. On each experimental day, volunteers were instructed to remember visual pictures while receiving neuronavigated rTMS trains (20 Hz, 900 ms) during picture encoding at the left dorsolateral prefrontal cortex (L-DLPFC) and the vertex. Mixed ANOVA model analyses were performed. rTMS to the L-DLPFC significantly disrupted recognition memory on experimental day 2. No differences were found between centers or between fMRI and EEG recordings. Subjects with lower baseline memory performances were more susceptible to TMS disruption. No stability of TMS-induced memory interference could be demonstrated on day 3. Our data suggests that adapted cognitive rTMS protocols can be implemented in multi-center studies incorporating standardized experimental procedures. However, our center and modality effects analyses lacked sufficient statistical power, hence highlighting the need to conduct further studies with larger samples. In addition, inter and intra-subject variability in response to TMS might limit its application in crossover or longitudinal studies.Nature Publishing Group2019201920182019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/129426Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41598-018-27502-1.Scientific Reports, 2018, vol. 8, num. 9371https://doi.org/10.1038/s41598-018-27502-1.info:eu-repo/grantAgreement/EC/FP7/115009cc-by (c) Martin Trias, Pablo et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1294262026-05-29T05:05:01Z
dc.title.none.fl_str_mv Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project
title Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project
spellingShingle Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project
Martin Trias, Pablo
Escorça cerebral
Neurociència cognitiva
Estimulació del cervell
Cerebral cortex
Cognitive neuroscience
Brain stimulation
title_short Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project
title_full Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project
title_fullStr Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project
title_full_unstemmed Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project
title_sort Adaptability and reproducibility of a memory disruption rTMS protocol in the PharmaCog IMI European project
dc.creator.none.fl_str_mv Martin Trias, Pablo
Lanteaume, Laura
Solana, Elisabeth
Cassé Perrot, Catherine
Fernández Cabello, Sara
Babiloni, Claudio
Marzano, Nicola
Junqué i Plaja, Carme, 1955-
Rossini, Paolo Maria
Micallef, Joëlle
Truillet, Romain
Charles, Estelle
Jouve, Elisabeth
Bordet, Régis
Santamaria Cano, Joan
Jovicich, Jorge
Rossi, Simone
Pascual Leone, Álvaro, 1961-
Blin, Olivier
Richardson, Jill
Bartrés Faz, David
author Martin Trias, Pablo
author_facet Martin Trias, Pablo
Lanteaume, Laura
Solana, Elisabeth
Cassé Perrot, Catherine
Fernández Cabello, Sara
Babiloni, Claudio
Marzano, Nicola
Junqué i Plaja, Carme, 1955-
Rossini, Paolo Maria
Micallef, Joëlle
Truillet, Romain
Charles, Estelle
Jouve, Elisabeth
Bordet, Régis
Santamaria Cano, Joan
Jovicich, Jorge
Rossi, Simone
Pascual Leone, Álvaro, 1961-
Blin, Olivier
Richardson, Jill
Bartrés Faz, David
author_role author
author2 Lanteaume, Laura
Solana, Elisabeth
Cassé Perrot, Catherine
Fernández Cabello, Sara
Babiloni, Claudio
Marzano, Nicola
Junqué i Plaja, Carme, 1955-
Rossini, Paolo Maria
Micallef, Joëlle
Truillet, Romain
Charles, Estelle
Jouve, Elisabeth
Bordet, Régis
Santamaria Cano, Joan
Jovicich, Jorge
Rossi, Simone
Pascual Leone, Álvaro, 1961-
Blin, Olivier
Richardson, Jill
Bartrés Faz, David
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Escorça cerebral
Neurociència cognitiva
Estimulació del cervell
Cerebral cortex
Cognitive neuroscience
Brain stimulation
topic Escorça cerebral
Neurociència cognitiva
Estimulació del cervell
Cerebral cortex
Cognitive neuroscience
Brain stimulation
description Transcranial magnetic stimulation (TMS) can interfere with cognitive processes, such as transiently impairing memory. As part of a multi-center European project, we investigated the adaptability and reproducibility of a previously published TMS memory interfering protocol in two centers using EEG or fMRI scenarios. Participants were invited to attend three experimental sessions on different days, with sham repetitive TMS (rTMS) applied on day 1 and real rTMS on days 2 and 3. Sixty-eight healthy young men were included. On each experimental day, volunteers were instructed to remember visual pictures while receiving neuronavigated rTMS trains (20 Hz, 900 ms) during picture encoding at the left dorsolateral prefrontal cortex (L-DLPFC) and the vertex. Mixed ANOVA model analyses were performed. rTMS to the L-DLPFC significantly disrupted recognition memory on experimental day 2. No differences were found between centers or between fMRI and EEG recordings. Subjects with lower baseline memory performances were more susceptible to TMS disruption. No stability of TMS-induced memory interference could be demonstrated on day 3. Our data suggests that adapted cognitive rTMS protocols can be implemented in multi-center studies incorporating standardized experimental procedures. However, our center and modality effects analyses lacked sufficient statistical power, hence highlighting the need to conduct further studies with larger samples. In addition, inter and intra-subject variability in response to TMS might limit its application in crossover or longitudinal studies.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/129426
url https://hdl.handle.net/2445/129426
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-27502-1.
Scientific Reports, 2018, vol. 8, num. 9371
https://doi.org/10.1038/s41598-018-27502-1.
info:eu-repo/grantAgreement/EC/FP7/115009
dc.rights.none.fl_str_mv cc-by (c) Martin Trias, Pablo et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Martin Trias, Pablo et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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