Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review

Acute kidney injury in patients who suffer a malignancy is a common complication. Due to its high prevalence and effective treatment, one of the most frequent causes that both oncologists and nephrologists must be aware of is acute tubulointerstitial nephritis (ATIN). ATIN is an immunomediated condi...

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Autores: Martinez Valenzuela, Laura, Draibe, Juliana, Fulladosa, Xavier, Gomà, Montse, Gómez, Francisco, Antón, Paula, Cruzado, Josep Ma., Torras Ambròs, Joan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/176001
Acceso en línea:https://hdl.handle.net/2445/176001
Access Level:acceso abierto
Palabra clave:Insuficiència renal
Nefrologia
Renal insufficiency
Nephrology
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spelling Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive ReviewMartinez Valenzuela, LauraDraibe, JulianaFulladosa, XavierGomà, MontseGómez, FranciscoAntón, PaulaCruzado, Josep Ma.Torras Ambròs, JoanInsuficiència renalNefrologiaRenal insufficiencyNephrologyAcute kidney injury in patients who suffer a malignancy is a common complication. Due to its high prevalence and effective treatment, one of the most frequent causes that both oncologists and nephrologists must be aware of is acute tubulointerstitial nephritis (ATIN). ATIN is an immunomediated condition and the hallmark of the disease, with the presence of a tubulointerstitial inflammatory infiltrate in the renal parenchyma. This infiltrate is composed mainly of T lymphocytes that can be accompanied by macrophages, neutrophils, or eosinophils among other cells. One of the major causes is drug-related ATIN, and some antineoplastic treatments have been related to this condition. Worthy of note are the novel immunotherapy treatments aimed at enhancing natural immunity in order to defeat cancer cells. In the context of the immunosuppression status affecting ATIN patients, some pathogen antigens can trigger the development of the disease. Finally, hematological malignancies can also manifest in the kidney leading to ATIN, even at the debut of the disease. In this review, we aim to comprehensively examine differential diagnosis of ATIN in the setting of a neoplastic patient.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/176001Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/ijms22052326International Journal of Molecular Sciences, 2021, vol. 22, num. 5https://doi.org/10.3390/ijms22052326cc by (c) Martínez Valenzuela et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1760012026-05-27T06:46:51Z
dc.title.none.fl_str_mv Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review
title Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review
spellingShingle Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review
Martinez Valenzuela, Laura
Insuficiència renal
Nefrologia
Renal insufficiency
Nephrology
title_short Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review
title_full Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review
title_fullStr Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review
title_full_unstemmed Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review
title_sort Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review
dc.creator.none.fl_str_mv Martinez Valenzuela, Laura
Draibe, Juliana
Fulladosa, Xavier
Gomà, Montse
Gómez, Francisco
Antón, Paula
Cruzado, Josep Ma.
Torras Ambròs, Joan
author Martinez Valenzuela, Laura
author_facet Martinez Valenzuela, Laura
Draibe, Juliana
Fulladosa, Xavier
Gomà, Montse
Gómez, Francisco
Antón, Paula
Cruzado, Josep Ma.
Torras Ambròs, Joan
author_role author
author2 Draibe, Juliana
Fulladosa, Xavier
Gomà, Montse
Gómez, Francisco
Antón, Paula
Cruzado, Josep Ma.
Torras Ambròs, Joan
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Insuficiència renal
Nefrologia
Renal insufficiency
Nephrology
topic Insuficiència renal
Nefrologia
Renal insufficiency
Nephrology
description Acute kidney injury in patients who suffer a malignancy is a common complication. Due to its high prevalence and effective treatment, one of the most frequent causes that both oncologists and nephrologists must be aware of is acute tubulointerstitial nephritis (ATIN). ATIN is an immunomediated condition and the hallmark of the disease, with the presence of a tubulointerstitial inflammatory infiltrate in the renal parenchyma. This infiltrate is composed mainly of T lymphocytes that can be accompanied by macrophages, neutrophils, or eosinophils among other cells. One of the major causes is drug-related ATIN, and some antineoplastic treatments have been related to this condition. Worthy of note are the novel immunotherapy treatments aimed at enhancing natural immunity in order to defeat cancer cells. In the context of the immunosuppression status affecting ATIN patients, some pathogen antigens can trigger the development of the disease. Finally, hematological malignancies can also manifest in the kidney leading to ATIN, even at the debut of the disease. In this review, we aim to comprehensively examine differential diagnosis of ATIN in the setting of a neoplastic patient.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/176001
url https://hdl.handle.net/2445/176001
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms22052326
International Journal of Molecular Sciences, 2021, vol. 22, num. 5
https://doi.org/10.3390/ijms22052326
dc.rights.none.fl_str_mv cc by (c) Martínez Valenzuela et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Martínez Valenzuela et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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