Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes

[EN]Cytokines, specially interleukin (IL)-6, play an important role in the differentiation and activation of osteoclasts and might be involved in osteoblast stimulation in Paget’s disease of bone (PDB). Objectives: The aim of this study was to investigate the association of polymorphisms in IL-6, IL...

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Autores: Corral-Gudino, Luis, Pino Montes, Javier del, García Aparicio, Judit, Alonso-Garrido, Manuel, González Sarmiento, Rogelio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/162418
Acceso en línea:http://hdl.handle.net/10366/162418
Access Level:acceso embargado
Palabra clave:Paget’s disease
Cytokines
Interleukin-6
Interleukin-8
Tumor necrosis factor
3209 Farmacología
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spelling Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genesCorral-Gudino, LuisPino Montes, Javier delGarcía Aparicio, JuditAlonso-Garrido, ManuelGonzález Sarmiento, RogelioPaget’s diseaseCytokinesInterleukin-6Interleukin-8Tumor necrosis factor3209 Farmacología[EN]Cytokines, specially interleukin (IL)-6, play an important role in the differentiation and activation of osteoclasts and might be involved in osteoblast stimulation in Paget’s disease of bone (PDB). Objectives: The aim of this study was to investigate the association of polymorphisms in IL-6, IL-8 and tumor necrosis factors-alpha (TNFA) genes among Spanish patients with PDB. Methods: We studied four single nucleotide polymorphisms (174 G > C IL-6, 251 T > A IL-8, 238 G > A TNFA and 308 G > A TNFA) in 172 PDB patients and 150 healthy controls. Distribution of alleles and proinflammatory genotypes were studied for association with the presence of the disease and with clinical and laboratory data, as well as the response to bisphosphonate treatment in PDB patients. Results: We found no statistically significant association between genotype and allele distribution of any of the cytokines polymorphism studied and PDB. No association between the clinical and therapeutic characteristics of PDB and the investigated polymorphism were found. Conclusions: This study does not support the hypothesis that the analyzed IL6, IL8 and TNFA polymorphism are associated with PDB.Elsevierinfo202520252010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10366/162418reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)Inglésinfo:eu-repo/semantics/embargoedAccessoai:gredos.usal.es:10366/1624182026-06-07T06:28:51Z
dc.title.none.fl_str_mv Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes
title Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes
spellingShingle Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes
Corral-Gudino, Luis
Paget’s disease
Cytokines
Interleukin-6
Interleukin-8
Tumor necrosis factor
3209 Farmacología
title_short Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes
title_full Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes
title_fullStr Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes
title_full_unstemmed Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes
title_sort Paget’s disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes
dc.creator.none.fl_str_mv Corral-Gudino, Luis
Pino Montes, Javier del
García Aparicio, Judit
Alonso-Garrido, Manuel
González Sarmiento, Rogelio
author Corral-Gudino, Luis
author_facet Corral-Gudino, Luis
Pino Montes, Javier del
García Aparicio, Judit
Alonso-Garrido, Manuel
González Sarmiento, Rogelio
author_role author
author2 Pino Montes, Javier del
García Aparicio, Judit
Alonso-Garrido, Manuel
González Sarmiento, Rogelio
author2_role author
author
author
author
dc.subject.none.fl_str_mv Paget’s disease
Cytokines
Interleukin-6
Interleukin-8
Tumor necrosis factor
3209 Farmacología
topic Paget’s disease
Cytokines
Interleukin-6
Interleukin-8
Tumor necrosis factor
3209 Farmacología
description [EN]Cytokines, specially interleukin (IL)-6, play an important role in the differentiation and activation of osteoclasts and might be involved in osteoblast stimulation in Paget’s disease of bone (PDB). Objectives: The aim of this study was to investigate the association of polymorphisms in IL-6, IL-8 and tumor necrosis factors-alpha (TNFA) genes among Spanish patients with PDB. Methods: We studied four single nucleotide polymorphisms (174 G > C IL-6, 251 T > A IL-8, 238 G > A TNFA and 308 G > A TNFA) in 172 PDB patients and 150 healthy controls. Distribution of alleles and proinflammatory genotypes were studied for association with the presence of the disease and with clinical and laboratory data, as well as the response to bisphosphonate treatment in PDB patients. Results: We found no statistically significant association between genotype and allele distribution of any of the cytokines polymorphism studied and PDB. No association between the clinical and therapeutic characteristics of PDB and the investigated polymorphism were found. Conclusions: This study does not support the hypothesis that the analyzed IL6, IL8 and TNFA polymorphism are associated with PDB.
publishDate 2010
dc.date.none.fl_str_mv 2010
2025
2025
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/162418
url http://hdl.handle.net/10366/162418
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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